ChemicalBook > CAS DataBase List > 3,6-DIMETHOXYPYRIDAZINE

3,6-DIMETHOXYPYRIDAZINE

Product Name
3,6-DIMETHOXYPYRIDAZINE
CAS No.
4603-59-2
Chemical Name
3,6-DIMETHOXYPYRIDAZINE
Synonyms
3,6-DIMETHOXYPYRIDAZINE;Pyridazine, 3,6-diMethoxy-;Pyridazine, 3,6-dimethoxy- (8CI)(9CI)
CBNumber
CB7353406
Molecular Formula
C6H8N2O2
Formula Weight
140.14
MOL File
4603-59-2.mol
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3,6-DIMETHOXYPYRIDAZINE Property

Melting point:
106 °C(Solv: water (7732-18-5))
Boiling point:
297.4±20.0 °C(Predicted)
Density 
1.131±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2.48±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C6H8N2O2/c1-9-5-3-4-6(10-2)8-7-5/h3-4H,1-2H3
InChIKey
HKQOBAGKDBSVEQ-UHFFFAOYSA-N
SMILES
C1(OC)=NN=C(OC)C=C1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC
Product number
D481023
Product name
3,6-Dimethoxypyridazine
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0111913
Product name
3,6-Dimethoxypyridazine
Purity
99.51%
Packaging
1g
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
OR909190
Product name
3,6-Dimethoxypyridazine
Purity
98%
Packaging
5g
Price
$435
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0310018
Product name
3,6-DIMETHOXYPYRIDAZINE
Purity
95.00%
Packaging
5MG
Price
$495.25
Updated
2021/12/16
ChemScene
Product number
CS-0111913
Product name
3,6-Dimethoxypyridazine
Purity
99.51%
Packaging
25g
Price
$583
Updated
2021/12/16
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3,6-DIMETHOXYPYRIDAZINE Chemical Properties,Usage,Production

Uses

3,6-Dimethoxypyridazine is used as a pharmaceutical intermediate in the preparation of sulfonylureas and sulfonylthioureas.

Synthesis

67-56-1

141-30-0

124-41-4

4603-59-2

General procedure for the synthesis of 3,6-dimethoxypyridazine from methanol, 3,6-dichloropyridazine and sodium methanol: 3,6-dichloropyridazine (10.0 g, 67.12 mmol) and sodium methanol (9.79 g, 181.23 mmol) were dissolved in methanol (39 mL) and the reaction was heated at 70 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (200 mL) and subsequently washed with water (100 mL x 2). The organic phase was dried over anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to afford the title compound 3,6-dimethoxypyridazine (9.46 g, 101% yield) as a white solid. The crude product could be directly used in the subsequent reaction without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.91 (s, 2H), 4.05 (s, 6H). Mass spectrometry (APCI) showed m/z = 182 ([M+H]+). HPLC analysis showed a retention time of 1.19 min.

References

[1] Patent: US2008/318943, 2008, A1. Location in patent: Page/Page column 73

3,6-DIMETHOXYPYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,6-DIMETHOXYPYRIDAZINE manufacturers

Shanghai Rlavie Technology Co ltd
Product
3,6-Dimethoxypyridazine 4603-59-2
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minGC
Supply Ability
500kgs/month
Release date
2021-11-05

4603-59-2, 3,6-DIMETHOXYPYRIDAZINERelated Search:

3,6-Pyridazinediamine(9CI) 3,4,5-TRICHLOROPYRIDAZINE 3,4-Dihydro-(1H)-benzopyrane 3,4-dichloropyridazine 3,6-Dimethyl Pyridazine 3,5-Dibromopyridazine 3,4,5-Tribromopyridazine 3,4,5,6-TETRACHLOROPYRIDAZINE 3,4,6-Tribromopyridazine 3,6-DIMETHOXYPYRIDAZINE-4-CARBOXYLIC ACID 3-CHLORO-4,5-DIMETHOXYPYRIDAZINE 4-CHLORO-3,5-DIMETHOXYPYRIDAZINE 5-CHLORO-3,4-DIMETHOXYPYRIDAZINE 6-CHLORO-3,4-DIMETHOXYPYRIDAZINE 3,6-Dimethoxypyridazine-4-carboxylic acid methyl ester METHYL 3,6-DIMETHOXYPYRIDAZINE-4-CARBOXYLATE 3,6-DIMETHOXYPYRIDAZINE 1-OXIDE (3,6-Dimethoxypyridazine-4-yl)phenylmethanol

  • 3,6-DIMETHOXYPYRIDAZINE
  • Pyridazine, 3,6-diMethoxy-
  • Pyridazine, 3,6-dimethoxy- (8CI)(9CI)
  • 4603-59-2