3,6-DIMETHOXYPYRIDAZINE
- Product Name
- 3,6-DIMETHOXYPYRIDAZINE
- CAS No.
- 4603-59-2
- Chemical Name
- 3,6-DIMETHOXYPYRIDAZINE
- Synonyms
- 3,6-DIMETHOXYPYRIDAZINE;Pyridazine, 3,6-diMethoxy-;Pyridazine, 3,6-dimethoxy- (8CI)(9CI)
- CBNumber
- CB7353406
- Molecular Formula
- C6H8N2O2
- Formula Weight
- 140.14
- MOL File
- 4603-59-2.mol
3,6-DIMETHOXYPYRIDAZINE Property
- Melting point:
- 106 °C(Solv: water (7732-18-5))
- Boiling point:
- 297.4±20.0 °C(Predicted)
- Density
- 1.131±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.48±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H8N2O2/c1-9-5-3-4-6(10-2)8-7-5/h3-4H,1-2H3
- InChIKey
- HKQOBAGKDBSVEQ-UHFFFAOYSA-N
- SMILES
- C1(OC)=NN=C(OC)C=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- D481023
- Product name
- 3,6-Dimethoxypyridazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0111913
- Product name
- 3,6-Dimethoxypyridazine
- Purity
- 99.51%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR909190
- Product name
- 3,6-Dimethoxypyridazine
- Purity
- 98%
- Packaging
- 5g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- CHM0310018
- Product name
- 3,6-DIMETHOXYPYRIDAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.25
- Updated
- 2021/12/16
- Product number
- CS-0111913
- Product name
- 3,6-Dimethoxypyridazine
- Purity
- 99.51%
- Packaging
- 25g
- Price
- $583
- Updated
- 2021/12/16
3,6-DIMETHOXYPYRIDAZINE Chemical Properties,Usage,Production
Uses
3,6-Dimethoxypyridazine is used as a pharmaceutical intermediate in the preparation of sulfonylureas and sulfonylthioureas.
Synthesis
67-56-1
141-30-0
124-41-4
4603-59-2
General procedure for the synthesis of 3,6-dimethoxypyridazine from methanol, 3,6-dichloropyridazine and sodium methanol: 3,6-dichloropyridazine (10.0 g, 67.12 mmol) and sodium methanol (9.79 g, 181.23 mmol) were dissolved in methanol (39 mL) and the reaction was heated at 70 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (200 mL) and subsequently washed with water (100 mL x 2). The organic phase was dried over anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to afford the title compound 3,6-dimethoxypyridazine (9.46 g, 101% yield) as a white solid. The crude product could be directly used in the subsequent reaction without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.91 (s, 2H), 4.05 (s, 6H). Mass spectrometry (APCI) showed m/z = 182 ([M+H]+). HPLC analysis showed a retention time of 1.19 min.
References
[1] Patent: US2008/318943, 2008, A1. Location in patent: Page/Page column 73
3,6-DIMETHOXYPYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
3,6-DIMETHOXYPYRIDAZINE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 3,6-DIMETHOXYPYRIDAZINE manufacturers
- Product
- 3,6-Dimethoxypyridazine 4603-59-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minGC
- Supply Ability
- 500kgs/month
- Release date
- 2021-11-05