2,4-DIAMINOQUINAZOLINE
- Product Name
- 2,4-DIAMINOQUINAZOLINE
- CAS No.
- 1899-48-5
- Chemical Name
- 2,4-DIAMINOQUINAZOLINE
- Synonyms
- 2,4-Quinazolinediamine;2,4-DIAMINOQUINAZOLINE;QUINAZOLINE-2,4-DIAMINE;2,4-DIAMINOQUINAZOLINE, 98+%;(2-aminoquinazolin-4-yl)amine
- CBNumber
- CB7356427
- Molecular Formula
- C8H8N4
- Formula Weight
- 160.18
- MOL File
- 1899-48-5.mol
2,4-DIAMINOQUINAZOLINE Property
- Melting point:
- 254-258°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- Appearance
- White to yellow Solid
- BRN
- 131578
- InChI
- InChI=1S/C8H8N4/c9-7-5-3-1-2-4-6(5)11-8(10)12-7/h1-4H,(H4,9,10,11,12)
- InChIKey
- XELRMPRLCPFTBH-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=CC=C2)=C(N)N=C1N
Safety
- Hazard Codes
- T
- Risk Statements
- 36/37/38-36-25
- Safety Statements
- 26-36-45
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS001152
- Product name
- 2,4-Diaminoquinazoline
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 500 mg
- Price
- $66.1
- Updated
- 2025/07/31
- Product number
- Q670110
- Product name
- Quinazoline-2,4-diamine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J52054
- Product name
- 2,4-Diaminoquinazoline
- Packaging
- 1g
- Price
- $30.3
- Updated
- 2021/12/16
- Product number
- FD149021
- Product name
- 2,4-Diaminoquinazoline
- Packaging
- 50mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 9892AA
- Product name
- 2,4-Diaminoquinazoline
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
2,4-DIAMINOQUINAZOLINE Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 33, p. 434, 1990 DOI: 10.1021/jm00163a067
Synthesis
127099-85-8
1885-29-6
1899-48-5
2-Aminobenzonitrile (10.0 g, 84.6 mmol) and cyanoguanidine (7.12 g, 84.6 mmol) were heated and refluxed in 42 ml of aqueous 2N HCl solution for 2 hours. After the reaction was completed, 320 ml of deionized water and 53 ml of 2N NaOH aqueous solution were added to the yellow solution. To remove unreacted feedstock, the reaction mixture was treated with activated carbon and filtered through a short column filled with diatomaceous earth. The filtrate was cooled to 4 °C and 2,4-diaminoquinazoline precipitated as colorless needle-like crystals, which were filtered and recrystallized from water to give 2.90 g (21% yield) of the target product. Melting point: 154-155 °C (literature value: 255-257 °C).1H-NMR (250 MHz, DMSO-d6) δ (ppm): 7.94 (dd, J=8.2 Hz, 1.1 Hz, 1H, Ar-H), 7.47 (dd, J=8.3 Hz, 6.8 Hz, 1.2 Hz, 1H, Ar-H), 7.25 ( br, 2H, NH2), 7.18 (dd, J=8.4 Hz, 0.8 Hz, 1H, Ar-H), 6.99 (ddd, J=8.3 Hz, 6.8 Hz, 1.2 Hz, 1H, Ar-H), 5.98 (s, 2H, NH2).13C-NMR (75.4 MHz, DMSO-d6) δ (ppm): 162.4, 160.7, 152.4, 132.3, 124.1, 123.5, 119.7, 110.3. IR (cm-1): 3505 (s), 3389 (s), 3172 (s), 3083 (m), 2827 (w), 2744 (w), 2669 (w), 2272 (w), 1952 (w). 1690(s), 1658(s), 1633(s), 1574(s), 1512(s), 1482(s), 1418(s), 1380(s), 1341(m), 1286(s), 1253(w), 1184(w), 1157(m), 1131(w), 1080(m), 1029(m). 993(m), 940(w), 928(w), 889(m), 856(m), 798(m), 753(s), 678(m), 590(m). Elemental analysis (C8H8N4, Mr=160.18): calculated values C 59.99%, H 5.03%, N 34.98%; measured values C 59.94%, H 5.08%, N 35.13%.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5576 - 5580
2,4-DIAMINOQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DIAMINOQUINAZOLINE manufacturers
- Product
- 2,4-DIAMINOQUINAZOLINE 1899-48-5
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12