ChemicalBook > CAS DataBase List > 2,4-DIAMINOQUINAZOLINE

2,4-DIAMINOQUINAZOLINE

Product Name: 2,4-DIAMINOQUINAZOLINE
CAS No.: 1899-48-5
Chemical Name: 2,4-DIAMINOQUINAZOLINE
Synonyms: 2,4-Quinazolinediamine;2,4-DIAMINOQUINAZOLINE;QUINAZOLINE-2,4-DIAMINE;2,4-DIAMINOQUINAZOLINE, 98+%;(2-aminoquinazolin-4-yl)amine
CBNumber: CB7356427
Molecular Formula: C8H8N4
Formula Weight: 160.18
MOL File: 1899-48-5.mol

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2,4-DIAMINOQUINAZOLINE Property

Melting point:: 254-258°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
Appearance: White to yellow Solid
BRN: 131578
InChI: InChI=1S/C8H8N4/c9-7-5-3-1-2-4-6(5)11-8(10)12-7/h1-4H,(H4,9,10,11,12)
InChIKey: XELRMPRLCPFTBH-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC=C2)=C(N)N=C1N

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Safety

Hazard Codes: T
Risk Statements: 36/37/38-36-25
Safety Statements: 26-36-45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS001152
Product name: 2,4-Diaminoquinazoline
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 500 mg
Price: $66.1
Updated: 2025/07/31

TRC

Product number: Q670110
Product name: Quinazoline-2,4-diamine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J52054
Product name: 2,4-Diaminoquinazoline
Packaging: 1g
Price: $30.3
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD149021
Product name: 2,4-Diaminoquinazoline
Packaging: 50mg
Price: $87
Updated: 2021/12/16

AK Scientific

Product number: 9892AA
Product name: 2,4-Diaminoquinazoline
Packaging: 1g
Price: $41
Updated: 2021/12/16

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2,4-DIAMINOQUINAZOLINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 434, 1990 DOI: 10.1021/jm00163a067

Synthesis

127099-85-8

1885-29-6

1899-48-5

2-Aminobenzonitrile (10.0 g, 84.6 mmol) and cyanoguanidine (7.12 g, 84.6 mmol) were heated and refluxed in 42 ml of aqueous 2N HCl solution for 2 hours. After the reaction was completed, 320 ml of deionized water and 53 ml of 2N NaOH aqueous solution were added to the yellow solution. To remove unreacted feedstock, the reaction mixture was treated with activated carbon and filtered through a short column filled with diatomaceous earth. The filtrate was cooled to 4 °C and 2,4-diaminoquinazoline precipitated as colorless needle-like crystals, which were filtered and recrystallized from water to give 2.90 g (21% yield) of the target product. Melting point: 154-155 °C (literature value: 255-257 °C).1H-NMR (250 MHz, DMSO-d6) δ (ppm): 7.94 (dd, J=8.2 Hz, 1.1 Hz, 1H, Ar-H), 7.47 (dd, J=8.3 Hz, 6.8 Hz, 1.2 Hz, 1H, Ar-H), 7.25 ( br, 2H, NH2), 7.18 (dd, J=8.4 Hz, 0.8 Hz, 1H, Ar-H), 6.99 (ddd, J=8.3 Hz, 6.8 Hz, 1.2 Hz, 1H, Ar-H), 5.98 (s, 2H, NH2).13C-NMR (75.4 MHz, DMSO-d6) δ (ppm): 162.4, 160.7, 152.4, 132.3, 124.1, 123.5, 119.7, 110.3. IR (cm-1): 3505 (s), 3389 (s), 3172 (s), 3083 (m), 2827 (w), 2744 (w), 2669 (w), 2272 (w), 1952 (w). 1690(s), 1658(s), 1633(s), 1574(s), 1512(s), 1482(s), 1418(s), 1380(s), 1341(m), 1286(s), 1253(w), 1184(w), 1157(m), 1131(w), 1080(m), 1029(m). 993(m), 940(w), 928(w), 889(m), 856(m), 798(m), 753(s), 678(m), 590(m). Elemental analysis (C8H8N4, Mr=160.18): calculated values C 59.99%, H 5.03%, N 34.98%; measured values C 59.94%, H 5.08%, N 35.13%.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5576 - 5580

2,4-DIAMINOQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-DIAMINOQUINAZOLINE manufacturers

Career Henan Chemical Co

Product: 2,4-DIAMINOQUINAZOLINE 1899-48-5
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

1899-48-5, 2,4-DIAMINOQUINAZOLINERelated Search:

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QUINAZOLINE-2,4-DIAMINE

2,4-DIAMINOQUINAZOLINE

2,4-DIAMINOQUINAZOLINE, 98+%

2,4-Quinazolinediamine

(2-aminoquinazolin-4-yl)amine

1899-48-5