ChemicalBook > CAS DataBase List > Methyl 5-chloro-2-nitrobenzoate

Methyl 5-chloro-2-nitrobenzoate

Product Name: Methyl 5-chloro-2-nitrobenzoate
CAS No.: 51282-49-6
Chemical Name: Methyl 5-chloro-2-nitrobenzoate
Synonyms: RARECHEM AL BF 0190;METHYL 5-CHLORO-2-NITROBENZOATE;METHYL 5-CHLORO-2-NITROBENZONATE;METHYL (2-NITRO-5-CHLORO)BENZOATE;5-chloro-3-methyl-2-nitrobenzoate;Methyl5-Chloro-2-nitrobenzoate>METHYL 5-CHLORO-2-NITROBENZOIC ACID;Methyl 5-chloro-2-nitrobenzoate,99%;5-chloro-2-nitro-benzoicacimethylester;4-Chloro-2-methoxycarbonylnitrobenzene
CBNumber: CB7360211
Molecular Formula: C8H6ClNO4
Formula Weight: 215.59
MOL File: 51282-49-6.mol

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Methyl 5-chloro-2-nitrobenzoate Property

Melting point:: 48-52 °C (lit.)
Boiling point:: 306.2±22.0 °C(Predicted)
Density: 1.4530
refractive index: 1.6000 (estimate)
Flash point:: >230 °F
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow
CAS DataBase Reference: 51282-49-6(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 5-chloro-2-nitro-, methyl ester (51282-49-6)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 36-37/39-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579823
Product name: Methyl 5-chloro-2-nitrobenzoate
Purity: 97%
Packaging: 5g
Price: $31.2
Updated: 2023/01/07

Sigma-Aldrich

Product number: 579823
Product name: Methyl 5-chloro-2-nitrobenzoate
Purity: 97%
Packaging: 25g
Price: $151
Updated: 2023/01/07

TCI Chemical

Product number: M1996
Product name: Methyl 5-Chloro-2-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: M1996
Product name: Methyl 5-Chloro-2-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $26
Updated: 2025/07/31

TRC

Product number: M295683
Product name: Methyl 5-chloro-2-nitrobenzoate
Packaging: 1g
Price: $70
Updated: 2021/12/16

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Methyl 5-chloro-2-nitrobenzoate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder or chunks

Synthesis

2516-95-2

74-88-4

51282-49-6

This embodiment relates to the synthesis of methyl 2-nitro-5-chlorobenzoate: to a stirred solution of 5-chloro-2-nitrobenzoic acid (9.393 g, 46.60 mmol) in anhydrous DMF (155 mL) at 0 °C was added potassium carbonate (K2CO3, 13.23 g, 95.72 mmol) and iodomethane (MeI, 19.38 g, 8.5 mL. 136.5 mmol), followed by slow warming of the reaction mixture to 40 °C. After 1 h of reaction, the solution was cooled to room temperature and diluted with ethyl acetate (EtOAc, 115 mL). The organic phase was washed sequentially with water (3 x 100 mL) and saturated sodium chloride solution (3 x 100 mL). The combined organic phases were dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure, and the resulting crude product was purified by silica gel column chromatography with 40-60% ethyl acetate/hexane as eluent to afford methyl 2-nitro-5-chlorobenzoate (9.244 g, 42.87 mmol, 92% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3).

References

[1] Journal of Organic Chemistry, 2007, vol. 72, # 26, p. 9857 - 9865
[2] Patent: WO2008/156656, 2008, A2. Location in patent: Page/Page column 44; 179-180

Methyl 5-chloro-2-nitrobenzoate Preparation Products And Raw materials

Raw materials

5-Chloro-2-nitrobenzoic acid Potassium carbonate Diethyl ether Dichloromethane Magnesium sulfate Dimethyl sulfate

Preparation Products

Bifenox

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View Lastest Price from Methyl 5-chloro-2-nitrobenzoate manufacturers

Career Henan Chemical Co

Product: Methyl 5-chloro-2-nitrobenzoate 51282-49-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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51282-49-6

51282-59-6

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acids

Aromatic Esters

Benzoic acid

Acids & Esters

Chlorine Compounds

Nitro Compounds

Carbonyl Compounds

Carboxylic Acids