Sincalide

Product Name: Sincalide
CAS No.: 25126-32-3
Chemical Name: Sincalide
Synonyms: CCK-8;Cholecystokinin octapeptide;Sincalide Acetate;Kinevac;Sincalid;SQ-19844;SINCALIDE;Sinkalite;Sincalid(CCK-8);CCK-8, SULFATED
CBNumber: CB7361692
Molecular Formula: C49H62N10O16S3
Formula Weight: 1143.27
MOL File: 25126-32-3.mol

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Sincalide Property

Melting point:: >193°C (dec.)
alpha: D23 -18.4° (c = 0.7 in 1N NH3)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: 0.05 M ammonium hydroxide: 1 mg/mL, clear, colorless
form: powder
pka: -4.17±0.18(Predicted)
color: Off-White
Water Solubility: Soluble in water 1 g/L at 10°C.
Merck: 13,8617
BRN: 5231801
Sequence: H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
InChIKey: IZTQOLKUZKXIRV-IVVJSLGPSA-N

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 8-10-21
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2175
Product name: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide
Purity: ≥97% (HPLC), powder
Packaging: 250μg
Price: $240
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2175
Product name: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide
Purity: ≥97% (HPLC), powder
Packaging: 0.5mg
Price: $415
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2175
Product name: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide
Purity: ≥97% (HPLC), powder
Packaging: 1mg
Price: $566
Updated: 2024/03/01

Alfa Aesar

Product number: J66669
Product name: Cholecystokinin, CCK Octapeptide (26-33)
Packaging: 0.5mg
Price: $102
Updated: 2023/06/20

Alfa Aesar

Product number: J66669
Product name: Cholecystokinin, CCK Octapeptide (26-33)
Packaging: 1mg
Price: $156
Updated: 2023/06/20

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Sincalide Chemical Properties,Usage,Production

Originator

Kinevac,Squibb,US,1976

Uses

Sincalide is used in the biological studies in the preparation of opioid receptors agonistic and CCK receptor antagonistic activity.

Uses

Choleretic.

Definition

ChEBI: Sincalide is an oligopeptide.

Manufacturing Process

The starting material in the following synthesis is: t-butyloxycarbonyl-Laspartyl- L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartyl-Lphenylalanine amide designated (SM)
.(A) A solution of (SM) (320 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate filtered, washed thoroughly with ether and dried. This material (280 mg) was added to concentrated sulfuric acid (20 ml), cooled at -20°C. The solution was kept in the dry ice-acetone bath at -20°C for 75 minutes. The sulfuric acid solution was poured into ice water (80 ml). The precipitate was centrifuged, resuspended in ice water (30 ml) and 4N sodium hydroxide was added until a clear solution was obtained. After reacidification to pH 4 with dilute sulfuric acid, the precipitate formed was centrifuged, washed twice with ice water and dried. Yield 155 mg. Chromatograph of DEAE Sephadex (with ammonium carbonate buffer) yielded the desired octapeptide sulfate ester: 30 mg.
(B) A solution of (SM) (330 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate was filtered, washed thoroughly with ether and dried. This material (300 mg) was added in portions to concentrated sulfuric acid (18 ml) cooled at -20°C with vigorous stirring. After 15 minutes a solution of potassium bisulfate in concentrated sulfuric acid (408 mg in 3 ml) was added. The reaction mixture was stirred for 75 minutes at -15°C and then stored at - 7°C for 285 minutes. The sulfuric acid solution was poured into cold ether (400 ml); precipitate was filtered, washed with cold ether, and suspended in cold water. Complete solution was then achieved by careful addition of 2N sodium hydroxide. Acidification with N hydrochloric acid led to the precipitation of the desired octapeptide sulfate ester. Yield 200 mg.

brand name

Kinevac (Bracco).

Therapeutic Function

Choleretic

General Description

It was thought originally that cholecystokinin and pancreozyminwere two different hormones. Cholecystokinin wasthought to be responsible for contraction of the gallbladder,whereas pancreozymin was believed to induce secretion ofpancreatic enzymes. It is now clear that both actions arecaused by a single 33-residue polypeptide, referred to ascholecystokinin–pancreozymin (CCK-PZ). CCK-PZ is secretedin the blood in response to the presence of food in theduodenum, especially long-chain fatty acids. The fiveCOOH-terminal amino acid residues are identical with thosein gastrin. The COOH-terminal octapeptide retains full activityof the parent hormone.

Biochem/physiol Actions

Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.

storage

Store at -20°C

Sincalide Preparation Products And Raw materials

Raw materials

Preparation Products

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Sincalide Suppliers

China 203 France 1 Germany 4 India 7 Japan 2 South Korea 1 Switzerland 5 United Kingdom 10 United States 26 Global 259

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View Lastest Price from Sincalide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Sincalide 25126-32-3
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Sincalide 25126-32-3
Price: US $0.00/GRAM
Min. Order: 1GRAM
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-04

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Sincalide 25126-32-3
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-02

25126-32-3, SincalideRelated Search:

sinapultide Oxytocin VAPREOTIDE Abaloparatide Ganirelix Acetate Etelcalcetide Thyrotropin-releasing hormone PASIREOTIDE Cholecystokinin desulfated sincalide (TYR9)-CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) Sincalide sincalide, pGlu- sincalide, Phe(CH2SO3Na)(2)- L-ILE-SER-ASP-ARG-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 BOC CCK-8 ([125I]-TYR)-CHOLECYSTOKININ OCTAPEPTIDE (DESULFATED) (OBUT1)-CHOLECYSTOKININ 26-33 PROTECTED

[27-TYR(SO3H)]CHOLECYSTOKININ-FRAGMENT (26-33)-AMIDE

PANCREOZYMIN C-TERMINAL OCTAPEPTIDE

SINCALIDE

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

Sincalid(CCK-8)

(tyr(so3H)27)-cholecystokinin fragment*26-33 amid

H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2

H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM SALT

CHOLECYSTOKININ [TYR(SO3H)27]-FRAGMENT 26-33 AMIDE

CHOLECYSTOKININ, OCTAPEPTIDE (26-33), SULFATED

CHOLECYSTOKININ OCTAPEPTIDE (SULFATED)

CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) AMMONIUM SALT

CHOLECYSTOKININ-8 (26-33), HUMAN, SULPHATED AMIDE

CHOLECYSTOKININ FRAGMENT 26-33 SULFATED

CHOLECYSTOKININ (26-33), SULFATED

CHOLECYSTOKININ (26-33) (SULFATED) AMMONIUM SALT

CCK OCTAPEPTIDE SULFATED

CCK, OCTAPEPTIDE (26-33), SULFATED

CCK-OCTAPEPTIDE (26-33) (SULFATED) AMMONIUM

CCK-OCTAPEPTIDE(26-33)(SULFATED FORM)

CCK OCTAPEPTIDE (CCK-8), SULFATED

CCK 26-33, SULFATED

CCK-8

CCK-8, SULFATED

CCK-8 (SULFATED) AMMONIUM

CCK-8 (SULFATED) AMMONIUM SALT

CCK-8 (26-33), HUMAN, SULPHATED AMIDE

D-Y(SO3H)-MGWMDF-NH2

ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2

ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM

CCK Octapeptide

CCK-8;SQ-19844;CCK OCTAPEPTIDE

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-(methylthio)-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl

SINCALIDE, >99%

Sincalide,CCK-8,SQ19844,Cholecystokinin octapeptide, >99%

Cholecystokinin octapeptide

SINCALIDE (CCK-8)

Sincalide ammonium salt

Cholecystokinin Octapeptide (sulfated),Sincalide

Sincalid

Sincalide Acetate

Cholecystokinin C-terminal octapeptide

Cholecystokinin-pancreozymin

SQ-19844

CCK-8, Cholecystokinin octapeptide, Pancreozymin C-terminal octapeptide, Sincalide

Cholecystokinin, CCK Octapeptide (26-33)

Cholecystokinin Octapeptide, sulfated, CCK-8S

Sincalide H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Cholecystokinin (26-33), CCK Octapeptide, sulfated

Cholecystokinin Octapeptide (sulfated) Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated)

Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated)

Sincalide (Kinevac)

3-10-Caerulein, 5-L-methionine-

Sincalide?Acetate impurity

Sincalide USP/EP/BP

Sincalide，CCK-8，SQ19844，Cholecystokinin octapeptide

Sincalide 25126-32-3

Sinkalite