1-Boc-Pyrrolidine
- Product Name
- 1-Boc-Pyrrolidine
- CAS No.
- 86953-79-9
- Chemical Name
- 1-Boc-Pyrrolidine
- Synonyms
- N-Boc;NT 0186;1-BOC-PYRROLIDINE;n-boc-pyrrolidine;N-1-BOC-Pyrrolidone;N-T-BOC-PYRROLIDINE;N-T-Boc-Pyrrolidone;N-Boc-pyrrolidine 97%;1-Boc-pyrrolidine,96%;N-tert-Boc-Pyrrolidine
- CBNumber
- CB7361768
- Molecular Formula
- C9H17NO2
- Formula Weight
- 171.24
- MOL File
- 86953-79-9.mol
1-Boc-Pyrrolidine Property
- Boiling point:
- 80 °C/0.2 mmHg (lit.)
- Density
- 0.977 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.449(lit.)
- Flash point:
- 187 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Oil
- pka
- -1.28±0.20(Predicted)
- color
- Clear Colorless
- BRN
- 4664750
- InChI
- InChI=1S/C9H17NO2/c1-9(2,3)12-8(11)10-6-4-5-7-10/h4-7H2,1-3H3
- InChIKey
- LPQZERIRKRYGGM-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCCC1
- CAS DataBase Reference
- 86953-79-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 427055
- Product name
- N-Boc-pyrrolidine
- Purity
- 97%
- Packaging
- 10g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- B3971
- Product name
- 1-tert-Butoxycarbonylpyrrolidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- B3971
- Product name
- 1-tert-Butoxycarbonylpyrrolidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $191
- Updated
- 2025/07/31
- Product number
- B665850
- Product name
- N-Boc-pyrrolidine
- Packaging
- 50g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 239973
- Product name
- N-Boc-
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
1-Boc-Pyrrolidine Chemical Properties,Usage,Production
Chemical Properties
liquid
Uses
N-Boc-pyrrolidine may be used in the synthesis of the following:
- 2-aryl-N-boc-pyrrolidines
- scalemic 2-pyrrolidinylcuprates
- 2-alkenyl-N-Boc-pyrrolidines
- 1-deoxycastanospermine
- methylphenidate analogues
- (+)-elaeokanine A
Uses
1-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.
General Description
N-Boc-pyrrolidine is an N-substituted pyrrolidine. It is reported that the reactivity of N-Boc-pyrrolidine towards C-H insertion reaction is 2000 times more than cyclohexane. It undergoes α-arylation in the presence of a palladium catalyst with high enantioselectivity.
Synthesis
123-75-1
24424-99-5
86953-79-9
The general procedure for the synthesis of 1-Boc-tetrandrine from tetrandrine and di-tert-butyl dicarbonate is as follows: the synthesis was carried out by a modified literature method (omitting the Sparteine chiral ligand), as specified in J. Am. Chem. Soc. 1994, 116, 3231.The steps are as follows: A) Preparation of Boc-protected pyrrolidines Triethylamine (TEA, 15.6 g, 0.15 mol) was slowly added to a dichloromethane (DCM, 150 mL) solution of pyrrolidine (10.0 g, 0.14 mol) in stirring at 0 °C. Subsequently, di-tert-butyl dicarbonate ((Boc)2O, 30.6 g, 0.14 mol) was added, and the reaction mixture was stirred at room temperature for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm complete pyrrolidine consumption. Upon completion of the reaction, the reaction mixture was washed sequentially with 1 M aqueous hydrochloric acid (100 mL) and brine, and the organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford the colorless, oily product 1-Boc-tetrandrine (24.0 g, 100%), which could be used in the subsequent steps without further purification.
References
[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Patent: WO2013/102242, 2013, A1. Location in patent: Page/Page column 94; 95
[3] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[4] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8267 - 8276
[5] Synthesis, 2001, # 4, p. 550 - 552
1-Boc-Pyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-Pyrrolidine Suppliers
- Tel
- 028-84252981
- Fax
- +86-28-84252965
- sales@chembon.com.cn
- Country
- China
- ProdList
- 850
- Advantage
- 64
- Tel
- 21-54820552 18964669552
- Fax
- 086-21-64964478
- 188738128@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 66
- Tel
- 021-57790084; 13918007836
- Fax
- 021-51685238
- sales@hoborchem.com
- Country
- China
- ProdList
- 392
- Advantage
- 60
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- +86-28-86127071
- Fax
- +86-28-86127072
- info@sino-produce.com
- Country
- China
- ProdList
- 406
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0519-89185693 15312551983
- Fax
- 0519-89185693
- 2410037592@qq.com
- Country
- China
- ProdList
- 261
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 15928766785 15928766785
- Fax
- QQ961458712
- wupengcheng@astatech.cn
- Country
- China
- ProdList
- 1987
- Advantage
- 55
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2966
- Advantage
- 60
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 20-66003216 18666003216
- Fax
- +86-20-28069063
- info@porsefinechemical.com
- Country
- China
- ProdList
- 1941
- Advantage
- 62
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 028-65294243 13981822079;18682730901
- sales@ampebiochem.com
- Country
- China
- ProdList
- 1000
- Advantage
- 58
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 6295
- Advantage
- 60
- Tel
- 13661411401
- Fax
- 51370935-8011
- yinglv.que@aqbiopharma.com.cn
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 022-60131465 18920720807
- Fax
- 022-58558581
- zishan_1986@163.com
- Country
- China
- ProdList
- 743
- Advantage
- 58
- Tel
- 13770809694
- Fax
- +86 25 56203983
- googlexu_0114@sina.com
- Country
- China
- ProdList
- 990
- Advantage
- 58
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
View Lastest Price from 1-Boc-Pyrrolidine manufacturers
- Product
- 1-Boc-Pyrrolidine 86953-79-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 1-Boc-Pyrrolidine 86953-79-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000Tons
- Release date
- 2024-08-04
- Product
- 1-Boc-Pyrrolidine 86953-79-9
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04