(R)-(-)-Nipecotic acid

Product Name: (R)-(-)-Nipecotic acid
CAS No.: 25137-00-2
Chemical Name: (R)-(-)-Nipecotic acid
Synonyms: (R)-(-)-Nipecotic ac;(R)-(-)-Nipecotic acid;Ethyl (R)-nipecotate, 95+%;(R)-(-)-NIPECOTIC ACID 97%;(R)-(-)-NIPECOTIC ACID HCL;D-Piperidine-3-carboxylic acid;(3R)-(-)-Piperidine-3-carboxyL;3-Piperidinecarboxylic acid, (R)-;R-(-)-Piperidine-3-carboxylic acid;(3R)-Piperidine-3α-carboxylic acid
CBNumber: CB7362361
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 25137-00-2.mol

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(R)-(-)-Nipecotic acid Property

Melting point:: 251-255 °C
alpha: -5 º (c=1, H2O)
Boiling point:: 265.8±33.0 °C(Predicted)
Density: 1.02g/cm
RTECS: TM6125390
refractive index: -4.5 ° (C=5, H2O)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Very Slightly), Water (Sparingly)
pka: 3.88±0.20(Predicted)
form: Solid
color: White to Beige
optical activity: [α]22/D 5°, c = 1 in H2O
CAS DataBase Reference: 25137-00-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 656356
Product name: (R)-(–)-3-Piperidinecarboxylic acid
Purity: 97%
Packaging: 10g
Price: $374
Updated: 2025/07/31

Sigma-Aldrich

Product number: 656356
Product name: (R)-(–)-3-Piperidinecarboxylic acid
Purity: 97%
Packaging: 1g
Price: $41.1
Updated: 2023/06/20

TCI Chemical

Product number: N0654
Product name: (R)-(-)-3-Piperidinecarboxylic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: N0654
Product name: (R)-(-)-3-Piperidinecarboxylic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $107
Updated: 2025/07/31

TRC

Product number: P482408
Product name: (R)-Piperidine-3-carboxylicAcid
Packaging: 50mg
Price: $55
Updated: 2021/12/16

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(R)-(-)-Nipecotic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

peptide synthesis

Definition

ChEBI: (R)-nipecotic acid is the (R)-enantiopmer of nipecotic acid. It is an enantiomer of a (S)-nipecotic acid. It is a tautomer of a (R)-nipecotic acid zwitterion.

General Description

(R)-(-)-3-Piperidinecarboxylic acid is an inhibitor of GABA (γ-aminobutyric acid) uptake.

Synthesis

4138-26-5

88495-55-0

498-95-3

The general procedure for the synthesis of (S)-piperidine-3-carboxamide and 3-piperidinecarboxylic acid from 3-piperidinecarboxamide is as follows: Example 3: Selective hydrolysis of the R-enantiomer of racemic 3-piperidinecarboxamide in Cupriavidus sp. strain KNK-J915 (FERM BP-10739). Bacterial cell suspensions were prepared by culturing strain KNK-J915 as in Example 1. 0.1 mL of bacterial cell suspension was mixed with 100 mM phosphate buffer (0.1 mL, pH 7.0) containing 1.0-5.0% racemic 3-piperidinecarboxamide and the mixture was reacted by shaking at 30°C for 35 hours. Upon completion of the reaction, solids such as bacterial cells were removed by centrifugation. Subsequently, the substrates and products in the reaction mixture were derivatized by reaction with benzyl chlorocarbonate. The resulting derivatives were analyzed by high performance liquid chromatography (HPLC) to determine conversion (percentage) and optical purity (ee percentage). The results are listed in Table 3. HPLC analysis conditions: - Conversion rate analyzing column: YMC-A303 (4.6 mm × 250 mm, manufactured by YMC Inc.), eluent: 20 mM aqueous phosphoric acid (pH 2.5)/acetonitrile = 7/3, flow rate: 1.0 mL/min, column temperature: 35 °C, detection wavelength: 210 nm. - Optical purity analysis column: CHIRALPAK AD-RH (4.6 mm × 150 mm, manufactured by Daicel Chemical Industries, Ltd.), eluent: 20 mM phosphate buffer (pH 2.5)/acetonitrile = 7/3, flow rate: 0.5 mL/min, column temperature: room temperature, detection wavelength: 210 nm.

References

[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 15

(R)-(-)-Nipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-Nipecotic acid Suppliers

Americas 1 China 148 Europe 3 Germany 3 India 7 Japan 8 Switzerland 1 United Kingdom 13 United States 34 Global 218

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View Lastest Price from (R)-(-)-Nipecotic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-(-)-Nipecotic acid 25137-00-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-(-)-Nipecotic acid 25137-00-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (R)-(-)-Nipecotic acid 25137-00-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

25137-00-2, (R)-(-)-Nipecotic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Folic acid Triacetonediamine Protocatechuic acid Glycine DROPERIDOL Haloperidol Citric acid Ascoric Acid (+/-)-NIPECOTIC ACID,NIPECOTIC ACID,(-)-D-NIPECOTIC ACID,L-NIPECOTIC ACID,D(-)-NIPECOTIC ACID,D-NIPECOTIC ACID,DL-NIPECOTIC ACID Diphenoxylate Piperidine D-1-BOC-NIPECOTIC ACID,N-BOC-(R)-NIPECOTIC ACID L-NIPECOTIC ACID ETHYL ESTER L-TARTRATE Catharanthine 2,5-DIBROMOPIPERIDINE TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE

(R)-(-)-NIPECOTIC ACID HCL

(R)-(-)-Nipecotic acid, (3R)-(-)-3-Carboxypiperidine

(R)-(-)-3-Piperidinecarboxylic acid 97%

Ethyl (R)-nipecotate, 95+%

(<i>R</i>)-(-)-3-Piperidinecarboxylic acid

(R)-(-)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

(R)-PIPERIDINE-3-CARBOXYLIC ACID HCL

(R)-(-)-PIPERIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE

(R)-(-)-NIPECOTIC ACID HYDROCHLORIDE

(R)-3-Piperidine-3-Carboxylic Acid HCl

D-Piperidine-3-carboxylic acid

R-(-)-Piperidine-3-carboxylic acid

(R)-(-)-NIPECOTIC ACID 97%

(R)-(-)-Nipecotic acid

(3R)-Piperidine-3α-carboxylic acid

(R)-(-)-Nipecotic ac

(R)-(-)-3-PiperidinecarboxylicAcid&gt

(3R)-(-)-Piperidine-3-carboxyL

3-Piperidinecarboxylic acid, (3R)-

3-Piperidinecarboxylic acid, (R)-

R-(-)-PIPERIDINE-3-CARBOXYLIC ACID 98%BATCH NO# AO/RNA/008/23

R-(-)-PIPERIDINE-3-CARBOXYLIC ACID 98%

NITROGEN(R-(-)PIPERIDINE-3-CARBOXYLIC)

(R)-(–)-3-Piperidinecarboxylic acid, 98%

(R)-Piperidine-3-carboxylic acid - [P12310]

25137-00-2

C8H11N2

Chiral Building Blocks

Asymmetric Synthesis

Piperidines

Heterocyclic Building Blocks

Carboxylic Acids (Chiral)

Chiral Building Blocks

Synthetic Organic Chemistry

Chiral Reagent

Piperidine

Piperidine Series

Nitrogen cyclic compounds

Beta amino acids