1-(2-Pyridyl)piperazine
- Product Name
- 1-(2-Pyridyl)piperazine
- CAS No.
- 34803-66-2
- Chemical Name
- 1-(2-Pyridyl)piperazine
- Synonyms
- NSC13778;NSC 26624;NSC 137781;AKOS BBS-00003613;BUTTPARK 82\08-03;RARECHEM AH CK 0193;TIMTEC-BB SBB006445;2-pyridyl piperazine;2-piperazinopyridine;LABOTEST-BB LTBB000605
- CBNumber
- CB7363328
- Molecular Formula
- C9H13N3
- Formula Weight
- 163.22
- MOL File
- 34803-66-2.mol
1-(2-Pyridyl)piperazine Property
- Melting point:
- 92-94
- Boiling point:
- 120-122 °C/2 mmHg (lit.)
- Density
- 1.072 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.595(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in Chloroform, Methanol.
- form
- Liquid
- pka
- 8.63±0.10(Predicted)
- color
- Clear colorless to yellow
- Water Solubility
- >500 g/L (20 ºC)
- Sensitive
- Air Sensitive
- BRN
- 140423
- InChI
- 1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
- InChIKey
- GZRKXKUVVPSREJ-UHFFFAOYSA-N
- SMILES
- C1CN(CCN1)c2ccccn2
- CAS DataBase Reference
- 34803-66-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-(2-Pyridyl)piperazine(34803-66-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 151270
- Product name
- 1-(2-Pyridyl)piperazine
- Purity
- 98%
- Packaging
- 5g
- Price
- $63.27
- Updated
- 2025/07/31
- Product number
- 151270
- Product name
- 1-(2-Pyridyl)piperazine
- Purity
- 98%
- Packaging
- 25g
- Price
- $122.55
- Updated
- 2025/07/31
- Product number
- P1033
- Product name
- 1-(2-Pyridyl)piperazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- P1033
- Product name
- 1-(2-Pyridyl)piperazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $219
- Updated
- 2025/07/31
- Product number
- 408166
- Product name
- 1-(2-Pyridyl)piperazine
- Purity
- ≥99%
- Packaging
- 5ml
- Price
- $68.02
- Updated
- 2025/07/31
1-(2-Pyridyl)piperazine Chemical Properties,Usage,Production
Chemical Properties
clear colourless to yellow liquid
Uses
1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli te of Azaperone (A802200).
Uses
1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.
General Description
1-(2-Pyridyl)piperazine is a piperazine derivative.
Synthesis
110-85-0
109-04-6
34803-66-2
Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield.
References
[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50
1-(2-Pyridyl)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2-Pyridyl)piperazine manufacturers
- Product
- 1-(2-pyridyl) piperazine 34803-66-2
- Price
- US $25.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-22
- Product
- 1-(2-Pyridinyl)piperazine 34803-66-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09
- Product
- 1-(2-Pyridyl)piperazine 34803-66-2
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%;99%
- Supply Ability
- 1kg； 5kg；10kg；25kg
- Release date
- 2020-01-07