ChemicalBook > CAS DataBase List > 1-(2-Pyridyl)piperazine

1-(2-Pyridyl)piperazine

Product Name
1-(2-Pyridyl)piperazine
CAS No.
34803-66-2
Chemical Name
1-(2-Pyridyl)piperazine
Synonyms
NSC13778;NSC 26624;NSC 137781;AKOS BBS-00003613;BUTTPARK 82\08-03;RARECHEM AH CK 0193;TIMTEC-BB SBB006445;2-pyridyl piperazine;2-piperazinopyridine;LABOTEST-BB LTBB000605
CBNumber
CB7363328
Molecular Formula
C9H13N3
Formula Weight
163.22
MOL File
34803-66-2.mol
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1-(2-Pyridyl)piperazine Property

Melting point:
92-94
Boiling point:
120-122 °C/2 mmHg (lit.)
Density 
1.072 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.595(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in Chloroform, Methanol.
form 
Liquid
pka
8.63±0.10(Predicted)
color 
Clear colorless to yellow
Water Solubility 
>500 g/L (20 ºC)
Sensitive 
Air Sensitive
BRN 
140423
CAS DataBase Reference
34803-66-2(CAS DataBase Reference)
NIST Chemistry Reference
1-(2-Pyridyl)piperazine(34803-66-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
2735
WGK Germany 
3
F 
10-34
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
II
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
151270
Product name
1-(2-Pyridyl)piperazine
Purity
98%
Packaging
5g
Price
$63.27
Updated
2025/07/31
Sigma-Aldrich
Product number
151270
Product name
1-(2-Pyridyl)piperazine
Purity
98%
Packaging
25g
Price
$122.55
Updated
2025/07/31
TCI Chemical
Product number
P1033
Product name
1-(2-Pyridyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
P1033
Product name
1-(2-Pyridyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$219
Updated
2025/07/31
Sigma-Aldrich
Product number
408166
Product name
1-(2-Pyridyl)piperazine
Purity
≥99%
Packaging
5ml
Price
$68.02
Updated
2025/07/31
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1-(2-Pyridyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

clear colourless to yellow liquid

Uses

1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli te of Azaperone (A802200).

Uses

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

General Description

1-(2-Pyridyl)piperazine is a piperazine derivative.

Synthesis

110-85-0

109-04-6

34803-66-2

Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield.

References

[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50

1-(2-Pyridyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-Pyridyl)piperazine manufacturers

Qiuxian Baitai New Material Co., LTD
Product
1-(2-pyridyl) piperazine 34803-66-2
Price
US $25.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-22
Career Henan Chemical Co
Product
1-(2-Pyridinyl)piperazine 34803-66-2
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09
Career Henan Chemical Co
Product
1-(2-Pyridyl)piperazine 34803-66-2
Price
US $0.01/KG
Min. Order
1KG
Purity
98%;99%
Supply Ability
1kg； 5kg；10kg；25kg
Release date
2020-01-07

34803-66-2, 1-(2-Pyridyl)piperazineRelated Search:

N-Aminoethylpiperazine 2-Ethylhexyl ferulate 1-Methylpiperazine Piperazine Piperacillin 1-[3-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINE 1-(5-Nitropyridin-2-yl)piperazine N,N'-(METHYLENEDICYCLOHEXYL)BIS[4-(2-PYRIDYL)-1-PIPERAZINECARBOXAMIDE] Quipazine 1-[5-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINE Enoxacin 1-[3-(Trifluoromethyl)-2-pyridyl]piperazine, 95+%,1-[3-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINE 1-(5-IODO-PYRIDIN-2-YL)-PIPERAZINE 1-(3-Pyridinyl)piperazine 1-(6-Chloro-5-bromo-3-pyridyl)piperazine 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine 1-(3,5-DICHLORO-4-PYRIDYL)PIPERAZINE TERT-BUTYL 4-[3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-PYRIDYL]PIPERAZINE-1-CARBOXYLATE

  • 2-pyridyl piperazine
  • 1-(2-PYRIDYL)PIPERAZINE, 99.5+%
  • 2-(1-piperazino)pyridine
  • 2-piperazinopyridine
  • 1-(Pyridin-2-yl)piperazine 98%
  • N-(4-PYRIDYL) PIPERAZINE
  • 1-PYRIDIN-2-YL-PIPERAZINE >98%
  • 1-(2-Pyridyl)piperazine ,98%
  • 1-pyridin-2-ylpiperazine(SALTDATA: FREE)
  • 4-(2-Pyridinyl)piperazine
  • 4-(2-Pyridyl)piperazine
  • N-(2-Pyridyl)piperazine
  • N-Pyridin-2-ylpiperazine
  • NSC 137781
  • NSC 26624
  • 2-(Piperazin-1-yl)pyridine
  • 1-(2-Pyridyl)piperazine, 98% 25GR
  • 1-(2-Pyridyl)piperazine, 98% 5GR
  • 1-(2-Pyridyl)piperazine >=99%
  • 1-(2-Pyridyl)piperazine 98%
  • Piperazine, 1-(2-pyridinyl)-
  • RARECHEM AH CK 0193
  • TIMTEC-BB SBB006445
  • 2-(1-PIPERAZINYL)PYRIDINE
  • 1-PYRIDIN-2-YL-PIPERAZINE
  • 1-(2-PYRIDYL)PIPERAZINE
  • 1-(2-PYRIDINYL)PIPERAZINE
  • AKOS BBS-00003613
  • LABOTEST-BB LTBB000605
  • BUTTPARK 82\08-03
  • 1-(2-Pyridyl)piperazine@2 mg/mL in Methylene chloride
  • 1-(2-Pyridyl)piperazine&gt
  • NSC13778
  • 1-(pyridine-2-yl)piperazine
  • 1-(pyridine)piperazine
  • 1-(2-pyridine)piperazine
  • 1-(2-Pyridyl)piperazine, ≥ 98.0%
  • 34803-66-2
  • C9H13N3
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • Pharmaceuticals
  • Piperidines, Piperidones, Piperazines
  • pharmacetical
  • API intermediates
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities