4-Hydroxy-3-nitrobenzonitrile
- Product Name
- 4-Hydroxy-3-nitrobenzonitrile
- CAS No.
- 3272-08-0
- Chemical Name
- 4-Hydroxy-3-nitrobenzonitrile
- Synonyms
- 2-NITRO-4-CYANOPHENOL;4-CYANO-2-NITROPHENOL;4-cyano-2-nitrophenolate;4-HYDROXY-3-NITROBENZONITRILE;3-Nitro-4-hydroxybenzonitrile;Benzonitrile, 4-hydroxy-3-nitro-;4-HYDROXY-3-NITROBENZONITRILE 97%;4-Hydroxy-3-nitrobenzonitrile,97%;4-BROMO-2,6-DIETHOXY-1-NITROBENZENE;4-Hydroxy-3-nitrobenzonitrile ISO 9001：2015 REACH
- CBNumber
- CB7363601
- Molecular Formula
- C7H4N2O3
- Formula Weight
- 164.12
- MOL File
- 3272-08-0.mol
4-Hydroxy-3-nitrobenzonitrile Property
- Melting point:
- 146-148 °C (lit.)
- Boiling point:
- 291.56°C (rough estimate)
- Density
- 1.5018 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.66±0.14(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C7H4N2O3/c8-4-5-1-2-7(10)6(3-5)9(11)12/h1-3,10H
- InChIKey
- INBLGVOPOSGVTA-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(O)C([N+]([O-])=O)=C1
- CAS DataBase Reference
- 3272-08-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39-36/37/39-24/25
- WGK Germany
- 3
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 344575
- Product name
- 4-Hydroxy-3-nitrobenzonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- H950868
- Product name
- 4-Hydroxy-3-nitrobenzonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W008477
- Product name
- 4-Hydroxy-3-nitrobenzonitrile
- Purity
- 99.53%
- Packaging
- 100g
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 087916
- Product name
- 4-Hydroxy-3-nitrobenzonitrile
- Packaging
- 10g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- 4655-1-0C
- Product name
- 4-Hydroxy-3-nitrobenzonitrile
- Packaging
- 5G
- Price
- $104
- Updated
- 2021/12/16
4-Hydroxy-3-nitrobenzonitrile Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
4-Hydroxy-3-nitrobenzonitrile may be used in the synthesis of:
- 3-azido-4-methoxybenzonitrile
- 4-methoxy-3-nitrobenzonitrile
- ethyl [2,2-dimethyl-6-(Δ2-thiazolin-2-yl)-4H-l,4-benzoxazin-3-one-4-yl]butyrate
General Description
4-Hydroxy-3-nitrobenzonitrile is one of the main photoproduct formed during hotolytic destruction of herbicide bromoxynil.
Synthesis
3011-34-5
3272-08-0
General procedure for the synthesis of 4-hydroxy-3-nitrobenzonitrile from 4-hydroxy-3-nitrobenzaldehyde: Aromatic aldehyde 1 (0.500 mmol, 1.0 eq.) and trimethylsilyl azide (TMSN3; 115 mg, 1.00 mmol, 2.0 eq.) were dissolved in a pre-mixed solvent mixture of hexafluoroisopropanol (HFIP) and acetonitrile (ACN) (2.0 mL, 1:1 volume ratio) in two dram vials, which was carried out under nitrogen protection. Subsequently, trifluoromethanesulfonic acid (TfOH; 17.7 μL, 0.200 mmol, 0.40 eq.) was added to the reaction system, and exothermic and rapid foaming phenomena due to gas production were immediately observed. The vial was quickly capped and the reaction mixture was stirred at room temperature for 20 to 75 min. Upon completion of the reaction, the reaction mixture was concentrated under a stream of nitrogen. The residue obtained was suspended in a solvent mixture of dichloromethane (CH2Cl2) and hexane and this suspension was upsampled into a cartridge containing 5 g silica gel. Purification was carried out by normal-phase silica gel fast column chromatography using a CombiFlash purification system, and suitable fractions were collected and concentrated to give the target product, aromatic nitrile 2.
References
[1] Journal of Organic Chemistry, 2012, vol. 77, # 12, p. 5364 - 5370
[2] Molecules, 2016, vol. 21, # 1,
[3] Patent: US5614520, 1997, A
4-Hydroxy-3-nitrobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxy-3-nitrobenzonitrile manufacturers
- Product
- 4-Hydroxy-3-nitrobenzonitrile 3272-08-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-20
- Product
- 4-Hydroxy-3-nitrobenzonitrile 3272-08-0
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4-Hydroxy-3-nitrobenzonitrile 3272-08-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-01-29