N,O-Bis(trimethylsilyl)acetamide

Description Uses

Product Name: N,O-Bis(trimethylsilyl)acetamide
CAS No.: 10416-59-8
Chemical Name: N,O-Bis(trimethylsilyl)acetamide
Synonyms: BSA;BIS(TRIMETHYLSILYL)ACETAMIDE;TriMethylsilyl N-(triMethylsilyl)acetiMidate;TMS-BA;dynasylan bsa;bis(trimethylsllyl)acetamide;N.O-Bis(trimethylsilyl)acetamide (BSA);(E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate;trimethylsilyl (1E)-N-trimethylsilylethanimidate;BSiA
CBNumber: CB7366985
Molecular Formula: C8H21NOSi2
Formula Weight: 203.43
MOL File: 10416-59-8.mol

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N,O-Bis(trimethylsilyl)acetamide Property

Melting point:: 24 °C
Boiling point:: 71-73 °C35 mm Hg(lit.)
Density: 0.832 g/mL at 20 °C(lit.)
vapor pressure: 10 hPa (50 °C)
refractive index: n20/D 1.417(lit.)
Flash point:: 53 °F
storage temp.: Store below +30°C.
solubility: Miscible with many nonpolar and polar aprotic solvents.
form: Crystalline Powder, Crystals and/or Chunks
pka: 5.82±0.50(Predicted)
Specific Gravity: 0.832
color: Light yellow or beige to brown
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
Sensitive: Moisture Sensitive
BRN: 1306669
CAS DataBase Reference: 10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference: Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System: Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)

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Safety

Hazard Codes: C,Xn,F
Risk Statements: 10-14-22-34-40-20/21/22-11
Safety Statements: 26-36/37/39-45-7/8-43A-36-30-23-16-7/9
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
RTECS: AK3000000
F: 10-21
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29310095
Toxicity: LD50 orally in Rabbit: 1580 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.18727
Product name: N,O-Bis(trimethylsilyl)acetamide
Purity: for synthesis
Packaging: 25mL
Price: $65.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18727
Product name: N,O-Bis(trimethylsilyl)acetamide
Purity: for synthesis
Packaging: 100mL
Price: $180
Updated: 2024/03/01

Sigma-Aldrich

Product number: 128910
Product name: N,O-Bis(trimethylsilyl)acetamide
Purity: synthesis grade, ≥95%
Packaging: 10ml
Price: $63.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 128910
Product name: N,O-Bis(trimethylsilyl)acetamide
Purity: synthesis grade, ≥95%
Packaging: 1l
Price: $639
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.09649
Product name: N,O-Bis(trimethylsilyl)acetamide
Purity: for gas chromatography
Packaging: 25mL
Price: $200
Updated: 2022/05/15

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N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Usage,Production

Description

Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Uses

Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
Used for blocking and protection of functional groups in organic intermediates;
Used for formation of derivatives of H-acid compounds for analysis;

The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Physical properties

bp 71–73°C/35 mmHg.

Uses

Powerful silylation reagent for a wide range of functional groups under mild conditions

Uses

N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.

Uses

N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional groups.
BSA was used to trimethylsilylate the hydroxyl group of 12 selectively to form in almost quantitative yield (eq 32).The presence of catalytic amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF) significantly promoted the silylation of alcohols under mild conditions with high chemoselectivity, i.e., TBAF plays a role as a smooth silyl transfer catalyst from nitrogen to the hydroxyl group.

Preparation

made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.

General Description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.

N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Triethylamine hydrochloride Acetamide Toluene Chlorotrimethylsilane

Preparation Products

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N,O-Bis(trimethylsilyl)acetamide Suppliers

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View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: N,O-Bis(trimethylsilyl)acetamide 10416-59-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Yanxi Chemical Co., Ltd.

Product: N,O-Bis(trimethylsilyl)acetamide 10416-59-8
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2024-05-08

Hebei Chuanghai Biotechnology Co,.LTD

Product: N,O-Bis(trimethylsilyl)acetamide 10416-59-8
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-16

10416-59-8, N,O-Bis(trimethylsilyl)acetamideRelated Search:

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dynasylan bsa

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N,O-BIS(TRIMETHYLSILYL)ACETAMIDE, FOR GC

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BIS-(TRIMETHYL SILYL) ACETAMIDE (BSA)

N,O-Bis(Trimethylsilyl)Acetamide(Bsa),Antibiotics

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N,O-BIS(TRIMETHYLSILY)ACETAMIDE

DYNASYLAN BSATrimethylsilyl N-trimethylsilylacetamidate

N,O-BIS(TRIMETHYLSILYL)ACETAMIDE

N,O-Bistrimethyl Sylyl Acetamide

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N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds]

N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 ml * 8 / Reaction vial, capacity 2 ml * 8

TMS-BA Kit BSA Kit

N,O-Bis(triMethylsilyl)ac...

BSA

N,O-BIS(TRIMETHYLSILYL)ACETAMIDE FOR GAS

TriMethylsilyl N-(triMethylsilyl)acetiMidate

Trimethylsilyl N-(trimethylsilyl)ethanimidate, N,O-Bis(trimethylsilyl)acetamide, BSA

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(E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate

BSA (25% in Acetonitrile)

N,O-Bis(triMethylsilyl)acetaMide synthesis grade, >=95%

N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester

N,O-Bis(trimethylsilyl)acetamide≥ 95% (Assay)

N,O-Bis(trimethylsiyl)acetamide 99%min

n-(trimethylsilyl)-acetimidicacitrimethylsilylester

n-(trimethylsilyl)-ethanimidicacitrimethylsilylester

Trimethylsilyl N-trimethylsilylacetamidate

TMS-BA

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N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8

Trimethylsilyl (1E)-N-[(E)-trimethylsilyl]ethanimidoate

N-Trimethylsilyl-1-trimethylsilyloxyethanimine

1-(Trimethylsiloxy)-N-(trimethylsilyl)ethanimine

N-(Trimethylsilyl)-1-(trimethylsiloxy)ethanimine

N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 ml * 8<br/>Reaction vial, capacity 2 ml * 8

N,O-Bis(trimethylsilyl)acetamide,95%

N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 [Trimethylsilylating Reagent, for NH2 compounds]

Bis(trimethylsilyl)acetamide 5g [10416-59-8]