ChemicalBook > CAS DataBase List > 2,3',4'-TRICHLOROACETOPHENONE

2,3',4'-TRICHLOROACETOPHENONE

Product Name: 2,3',4'-TRICHLOROACETOPHENONE
CAS No.: 42981-08-8
Chemical Name: 2,3',4'-TRICHLOROACETOPHENONE
Synonyms: 3,4-DICHLOROPHENACYL CHLORIDE;2,3',4'-TRICHLOROACETOPHENONE;2-Chloro-1-(3,4-dichlorophenyl);3,4-Dichlorophenacyl chloride 95%;3,4-Dichloro-a-chloroacetophenone;2-chloro-3-4-dichloroacetophenone;2-CHLORO-1-(3,4-DICHLORO-PHENYL)-ETHANONE;Ethanone, 2-chloro-1-(3,4-dichlorophenyl)-;2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one;2-CHLORO-1-(3,4-DICHLOROPHENYL)-1-ETHANONE
CBNumber: CB7367876
Molecular Formula: C8H5Cl3O
Formula Weight: 223.48
MOL File: 42981-08-8.mol

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2,3',4'-TRICHLOROACETOPHENONE Property

Melting point:: 46-47°C
Boiling point:: 171-173°C 15mm
Density: 1.430±0.06 g/cm3(Predicted)
Flash point:: 171-173°C/15mm
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in methanol.
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 42981-08-8(CAS DataBase Reference)

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Safety

Risk Statements: 34
Safety Statements: 36/37/39
RIDADR: 1759
HazardClass: 8
PackingGroup: III
HS Code: 2914390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1965
Product name: 2,3',4'-Trichloroacetophenone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TRC

Product number: B585903
Product name: 2,3'',4''-Trichloroacetophenone
Packaging: 50mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B585903
Product name: 2,3'',4''-Trichloroacetophenone
Packaging: 100mg
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-5-03
Product name: 3,4-Dichlorophenacyl chloride
Purity: 98.00%
Packaging: 5G
Price: $39
Updated: 2021/12/16

Matrix Scientific

Product number: 138716
Product name: 2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one
Purity: 95%+
Packaging: 2.500g
Price: $215
Updated: 2021/12/16

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2,3',4'-TRICHLOROACETOPHENONE Chemical Properties,Usage,Production

Uses

2,3',4'-Trichloroacetophenone is used as an organic chemical synthesis intermediate.

Synthesis

79-04-9

95-50-1

42981-08-8

General method: 1,2-Dichlorobenzene (50 g, 340 mmol) was mixed with anhydrous AlCl3 (45.354 g, 340 mmol) and heated to 70 °C. The mixture was then heated to 70 °C. The reaction was followed by the addition of 3-chloropropionyl chloride (47.506 g, 374 mmol). Subsequently, 3-chloropropionyl chloride (47.506 g, 374 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously at 70 °C for 6 hours. After the reaction was completed, it was cooled to room temperature and diluted with dichloromethane (300 mL). The diluted mixture was slowly poured into ice water (200 mL) and stirred for 30 minutes. The organic layer was separated, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/50, V/V) to afford the target product 2,3',4'-trichloroacetophenone (compound 2a) as a white solid (64.6 g, 80% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 24, p. 5420 - 5423
[2] Quarterly Journal of Pharmacy and Pharmacology, 1932, vol. 5, p. 500
[3] Chem. Zentralbl., 1933, vol. 104, # I, p. 605
[4] Roczniki Chemii, 1933, vol. 13, p. 293,295
[5] Chem. Zentralbl., 1933, vol. 104, # II, p. 1516

2,3',4'-TRICHLOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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42981-08-8, 2,3',4'-TRICHLOROACETOPHENONERelated Search:

2,2',4'-Trichloroacetophenone 224-trichloroacetophenone (intermediate of ketoconazole) 2',3',3'-TRICHLOROACETOPHENONE 2,3,4-TRICHLOROACETOPHENONE,2',3',4'-TRICHLOROACETOPHENONE P-TERT-BUTYL-2,2,2-TRICHLOROACETOPHENONE 2',4',5'-Trichloroacetophenone 4'-(3-Amino-1H-pyrazol-4-yl)-α,α,α-trichloroacetophenone,4'-(3-Amino-1H-pyrazol-4-yl)-ω,ω,ω-trichloroacetophenone α-Bromo-2',3',4'-trichloroacetophenone 2,2,2-trichloroacetophenone 2,2,2',4',5'-PENTACHLOROACETOPHENONE AURORA KA-3275 AURORA KA-4735 AURORA KA-3554 AKOS B024909 AURORA KA-3669 2,3',4'-TRICHLOROACETOPHENONE

3,4-DICHLOROPHENACYL CHLORIDE

1-ETHANONE, 2-CHLORO-1-(3,4-DICHLOROPHENYL)-

2-CHLORO-1-(3,4-DICHLOROPHENYL)-1-ETHANONE

2-CHLORO-1-(3,4-DICHLORO-PHENYL)-ETHANONE

2-chloro-3-4-dichloroacetophenone

2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one, 2,3',4'-Trichloroacetophenone

3,4-Dichlorophenacyl chloride 95%

2-Chloro-1-(3,4-dichlorophenyl)

2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one

Ethanone, 2-chloro-1-(3,4-dichlorophenyl)-

3,4-Dichloro-a-chloroacetophenone

2,3',4'-TRICHLOROACETOPHENONE

2,3′,4′-Trichloroacetophenone, CAS 42981-08-8

42981-08-8