2,2',4'-Trichloroacetophenone

Product Name: 2,2',4'-Trichloroacetophenone
CAS No.: 4252-78-2
Chemical Name: 2,2',4'-Trichloroacetophenone
Synonyms: 2-CHLORO-1-(2,4-DICHLOROPHENYL)ETHANONE;TRICHLOROACETOPHENONE;2,2′,4′-Trichloracetophenon;Ethanone, 2-chloro-1-(2,4-dichlorophenyl)-;alpha-2,4-Tric;2,2',4'-TrichL;2,2',4-Trichloro;TRICHLOROACETOPHENON;Econazole Impurity 11;LABOTEST-BB LT00233191
CBNumber: CB9689842
Molecular Formula: C8H5Cl3O
Formula Weight: 223.48
MOL File: 4252-78-2.mol

More

Less

2,2',4'-Trichloroacetophenone Property

Melting point:: 47-54 °C(lit.)
Boiling point:: 130-135 °C4 mm Hg(lit.)
Density: 1,312 g/cm³
refractive index: 1.5510 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 60 mg/L (20°C)
form: Solid
color: beige to yellow
PH: 4.96 at 25.1℃ and 10g/L
Water Solubility: 60 mg/L (20 ºC)
Sensitive: Lachrymatory
BRN: 957098
CAS DataBase Reference: 4252-78-2(CAS DataBase Reference)
EPA Substance Registry System: Ethanone, 2-chloro-1-(2,4-dichlorophenyl)- (4252-78-2)

More

Less

Safety

Hazard Codes: Xi,C,N,T
Risk Statements: 37/38-41-43-51/53-34-23/24/25
Safety Statements: 26-36/37/39-61-45-37/39
RIDADR: 1759
WGK Germany: 3
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III
HS Code: 29147090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159255
Product name: 2,2′,4′-Trichloroacetophenone
Purity: 97%
Packaging: 25g
Price: $61.7
Updated: 2025/07/31

TCI Chemical

Product number: T1405
Product name: 2,2',4'-Trichloroacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: T1405
Product name: 2,2',4'-Trichloroacetophenone
Purity: >98.0%(GC)
Packaging: 250g
Price: $223
Updated: 2025/07/31

TRC

Product number: T774315
Product name: α,2,4-Trichloroacetophenone
Packaging: 100g
Price: $250
Updated: 2021/12/16

TRC

Product number: T774315
Product name: α,2,4-Trichloroacetophenone
Packaging: 50g
Price: $150
Updated: 2021/12/16

More

Less

2,2',4'-Trichloroacetophenone Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powde

Uses

α,2,4-Trichloroacetophenone is a reagent used in the synthesis of isoconazole, a potent antifungal agent.

General Description

Off-white crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,2',4'-Trichloroacetophenone is incompatible with strong oxidizers and strong bases. .

Fire Hazard

2,2',4'-Trichloroacetophenone is probably combustible.

Synthesis

79-04-9

541-73-1

4252-78-2

To a three-necked flask equipped with a stirrer was added 1,3-dichlorobenzene (147 g), chloroacetyl chloride (113 g) and methylene chloride (750 mL) at room temperature. Under stirring, anhydrous aluminum trichloride (147 g) was added in batches. After the addition was complete, the reaction mixture was heated to reflux and maintained for 3 hours to ensure complete reaction. Upon completion of the reaction, the mixture was quenched by carefully pouring it into ice water. Subsequently, the organic and aqueous phases were separated. The organic phase was washed sequentially with deionized water (500 mL x 2) and saturated sodium bicarbonate solution (500 mL x 2) to remove acidic impurities. The washed organic phase was dried with anhydrous sodium sulfate and filtered to remove the desiccant. The filtrate was concentrated by rotary evaporation and petroleum ether (1200 mL) was added to the residue. The mixture was cooled to room temperature and placed in a refrigerator overnight to promote crystallization. The following day, the crystallized product was collected by filtration and washed with a small amount of cold petroleum ether. Ultimately, the product was dried under vacuum to give 2,2',4'-trichloroacetophenone (193 g, 86% yield) in the form of an off-white solid.

References

[1] Journal of Chemical Sciences, 2015, vol. 127, # 12, p. 2251 - 2260
[2] Patent: CN105566309, 2016, A. Location in patent: Paragraph 0003; 0007
[3] Chemische Berichte, 1907, vol. 40, p. 1703
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 24, p. 3861 - 3866
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5368 - 5371

2,2',4'-Trichloroacetophenone Preparation Products And Raw materials

Raw materials

Chloroacetyl chloride

Preparation Products

ALPHA-(CHLOROMETHYL)-2,4-DICHLOROBENZYL ALCOHOL Oxiconazole nitrate

More

Less

2,2',4'-Trichloroacetophenone Suppliers

Belgium 2 Canada 3 China 293 Europe 3 France 1 Germany 11 India 48 Japan 5 Slovakia 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 15 United States 50 Global 438

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Weifang QianJin Fine Chemical Co., Ltd.

Tel: 18753684562
Fax: 0536-8897109
Email: 1577399715@qq.COM
Country: China
ProdList: 1735
Advantage: 55

Hubei Hongfuda Biotechnology Co., Ltd.

Tel: 19107255884
Email: 259506217@qq.com
Country: China
ProdList: 2188
Advantage: 58

Changzhou Ditong chemical Co.,Ltd.

Tel: 0519-88298848 18118010980
Fax: 0519-85130733
Email: info@edengenechem.com
Country: China
ProdList: 736
Advantage: 58

Hunan Xinbelai Biotechnology Co., LTD

Tel: 18667946270
Email: wangzeren@synbiolab.cn
Country: China
ProdList: 89
Advantage: 58

Yulin Runtianchang Chemical Co., Ltd

Tel: 15890142075
Email: 3555133855@qq.com
Country: China
ProdList: 9850
Advantage: 58

Weixin Pharmaceutical (Shanghai) Co., Ltd

Tel: 021-51143139 13564188768
Email: sales@gipharma.com.cn
Country: China
ProdList: 73
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

More

Less

View Lastest Price from 2,2',4'-Trichloroacetophenone manufacturers

Shanghai Qyubiotech Co., Ltd.

Product: 2,2',4'-Trichloroacetophenone 4252-78-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%+
Supply Ability: 100000kgs per month
Release date: 2024-04-07

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2,2',4'-Trichloroacetophenone 4252-78-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-06

Henan Aochuang Chemical Co.,Ltd.

Product: 2,2',4'-Trichloroacetophenone 4252-78-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

4252-78-2, 2,2',4'-TrichloroacetophenoneRelated Search:

2',4'-Dichloroacetophenone Choline chloride Sodium chloride Ammonium chloride Calcium chloride 3-Nitroacetophenone 4-Nitroacetophenone 4'-Hydroxyacetophenone 4'-Chloroacetophenone 4'-Bromoacetophenone 3'-Chloroacetophenone 2-Chloroacetophenone Oxalyl chloride L-PICEIN 2-Bromoacetophenone Dichloroacetonitrile Potassium chloride Zinc chloride

à,2,4-trichloroacetophenone

alpha-2,4-trichloroacetophenon

ω,2,4-trichloroacetophenone

TRICHLOROACETOPHENONE

2,2′,4′-Trichloracetophenon

2-2,4-TRICHLORO ACETOPHENONE 99+%

2-chloro-2’,4’-dichloroacetophenone,2,2',4'-trichloroacetophenone

2,2'',4''-TRICHLOROACETOPHENONEECONAZOLE

2,2',4'-TRICHLOROACETOPHENONE, TECH., 90%

2-Chloro-24Dichloroacetophenone

2',4'-Dichloro-α-chloroacetophenone

(Trichloroacetyl)benzene

2,2',4'-Trichloroacetophenone,95%

2,2',4'-Trichloroacetophenone,90%,tech.

ω,2,4-Trichloroacetophenone, 2,4-Dichlorophenacyl chloride

2,2′,4′-Trichloroacetophenone,ω,2,4-Trichloroacetophenone, 2,4-Dichlorophenacyl chloride

2,2',4'-Trichloroacetophenone, 2-Chloro-1-(2,4-dichlorophenyl)ethan-1-one

2,2 ', 4'-trichloro acetophenone 2,2,4-trichloro acetophenone

2, 4-trichlorobenzene trichlorobenzene ethyl ketone

alpha-2,4-Tric

2,2',4'-TRICHLORO PHENYL ETH

LABOTEST-BB LT00233191

2,2',4-TRICHLOROACETOPHENENONE

2,2',4-TRICHLORO ACETOPHENONE

2,2,4-TRICHLORO ACETOPHENONE

2',2,4-TRICHLOROACETOPHENONE

2,2',4'-TRICHLORO PHENYL ETHANONE

2,4-DICHLOROPHENACYL CHLORIDE

2-CHLORO-1-(2,4-DICHLOROPHENYL)ETHANONE

A,2,4-TRICHLOROACETOPHENONE

ALPHA-CHLORO-2,4-DICHLOROACETOPHENONE

ALPHA,2,4-TRICHLOROACETOPHENONE

alpha,2,4-Trichloroacetophenone~2,2,4-Trichloroacetophenone

chloromethyl 2,4-dichlorophenyl ketone

TRICHLOROACETOPHENON

2,2',4'-Trichloroacetophenone 2-Chloro-1-(2,4-Dichlorophenyl)ethanone

2,4,W-Trichloroacetophenon

2,2',4-Trichloro

Ethanone, 2-chloro-1-(2,4-dichlorophenyl)-

2,4-dichlorphenacylchloride

OMEGA,2,4-TRICHLOROACETOPHENONE

Econazole Impurity 11

2,2',4'-TrichL

α,2,4-Trichloroacetophenone

2,2',4'- Trichloroacetopheone

2,2,4-Dichloro phenacyl Chloride / 2,2,4- trichloro acetophenone

2,2',4'-Trichloroacetophenone

2,2′,4′-Trichloroacetophenone, CAS 4252-78-2

4252-78-2

4252-78-0

Cl2C6H3COCH2Cl

C8H5CI3O

Building Blocks

C7 to C8

Carbonyl Compounds

Ketones

Organic Building Blocks

Acetophenone Series