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Oxiconazole nitrate

Product Name
Oxiconazole nitrate
CAS No.
64211-46-7
Chemical Name
Oxiconazole nitrate
Synonyms
Oceral;Oxistat;Myfungar;Okiconale;Sgd-301-76;Ro-13-8996;Okiconale V;Gyno-Myfungar;Oxiconazole nitrate;nitrate,(z)-methyl)oxim
CBNumber
CB5251601
Molecular Formula
C18H13Cl4N3O
Formula Weight
429.13
MOL File
64211-46-7.mol
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Oxiconazole nitrate Property

Melting point:
137-1380C
storage temp. 
Refrigerator
solubility 
Chloroform, Methanol (Sparingly)
form 
Solid
color 
Off-White
CAS DataBase Reference
64211-46-7(CAS DataBase Reference)
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Safety

HS Code 
2933290000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18724
Product name
Oxiconazole (nitrate)
Purity
≥98%
Packaging
1g
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
18724
Product name
Oxiconazole (nitrate)
Purity
≥98%
Packaging
5g
Price
$347
Updated
2024/03/01
Cayman Chemical
Product number
18724
Product name
Oxiconazole (nitrate)
Purity
≥98%
Packaging
25g
Price
$1153
Updated
2024/03/01
TRC
Product number
O846800
Product name
OxiconazoleNitrate
Packaging
100mg
Price
$1070
Updated
2021/12/16
Usbiological
Product number
286092
Product name
Oxiconazole nitrate
Packaging
5mg
Price
$403
Updated
2021/12/16
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Oxiconazole nitrate Chemical Properties,Usage,Production

Description

Oxiconazole nitrate is a broad-spectrum antifungal agent indicated for the treatment of skin infections due to yeasts, dermatophytes, yeast-like fungi and molds, and gram positive organisms.

Description

Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes. Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.

Chemical Properties

Crystalline Solid

Originator

Siegfried (Switzerland)

Uses

Topical aTopical antimycotic agent. agent.

Uses

radiopaque agent

Definition

ChEBI: An organic nitrate salt resulting from the reaction of equimolar amounts of oxiconazole and nitric acid. An antifungal agent, it is used in creams and powders for the topical treatment of fungal skin infections.

Manufacturing Process

13.5 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime are dissolved in 100 ml dimethylformamide (DMF) and 1.2 g of sodium hydride are mixed in, whereupon an exothermic reaction is allowed to take place on its own with stirring. After cessation of evolution of hydrogen, a solution of 9.8 g of 2,4-dichlorobenzyl chloride in 10 cc DMF is added dropwise with continuous stirring and the stirring is carried on for 2 hours further. The reaction is then taken to completion at a bath temperature of 80°C, after which the reaction mixture is evaporated in a rotation evaporator under reduced pressure and the residue is dissolved in 100 ml ethanol. After filtering off of undissolved matter, the solution is stirred with 300 ml 2N nitric acid for the conversion of free base to the nitrate.
The liquid standing over the heavy deposits which have separated out is separated off by decanting, whereupon an isomer is obtained which after recrystallization from ethanol is obtained in a yield of 5.2 g and having a melting point of 137°C to 138°C.

brand name

Oxistat (Altana);OCERAL;MYFUNGAR.

Therapeutic Function

Antifungal

Clinical Use

(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone-O-[2,4-dichlorophenyl)methyl]oxime mononitrate (Oxistat)is a white crystalline nitric acid salt. It is used in cream andlotion dosage forms in 1% concentration for the treatment oftinea pedis, tinea corporis, and tinea capitis.

in vitro

oxiconazole is highly effective against many dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton tonsurans, and epidermophyton floccosum. after application to the skin, oxiconazole is rapidly absorbed into the stratum corneum, maximum concentrations often being attained within 100 minutes. fungicidal concentrations are maintained in the epidermis, upper corium, and deeper corium for at least five hours, and levels exceeding the minimum inhibitory concentrations of susceptible fungi are present in the corneum, epidermis, upper corium, and the hair follicle for over 16 hours [2].

References

[1] polak a. oxiconazole, a new imidazole derivative. evaluation of antifungal activity in vitro and in vivo[j]. arzneimittel-forschung, 1981, 32(1): 17-24.
[2] jegasothy b v, pakes g e. oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent[j]. clinical therapeutics, 1990, 13(1): 126-141.

Oxiconazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxiconazole nitrate Suppliers

Hunan Zhongwei Pharmaceutical Co. Ltd.
Tel
0731-22581555
Fax
0731-22841821
Email
hnzwzy@sina.com
Country
China
ProdList
1
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from Oxiconazole nitrate manufacturers

Dideu Industries Group Limited
Product
Oxiconazole nitrate 64211-46-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxiconazole nitrate 64211-46-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxiconazole nitrate 64211-46-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

64211-46-7, Oxiconazole nitrateRelated Search:


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