ChemicalBook > CAS DataBase List > 2,3',4'-TRICHLOROACETOPHENONE

2,3',4'-TRICHLOROACETOPHENONE

Product Name
2,3',4'-TRICHLOROACETOPHENONE
CAS No.
42981-08-8
Chemical Name
2,3',4'-TRICHLOROACETOPHENONE
Synonyms
3,4-DICHLOROPHENACYL CHLORIDE;2,3',4'-TRICHLOROACETOPHENONE;2-Chloro-1-(3,4-dichlorophenyl);3,4-Dichlorophenacyl chloride 95%;3,4-Dichloro-a-chloroacetophenone;2-chloro-3-4-dichloroacetophenone;2-CHLORO-1-(3,4-DICHLORO-PHENYL)-ETHANONE;Ethanone, 2-chloro-1-(3,4-dichlorophenyl)-;2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one;2-CHLORO-1-(3,4-DICHLOROPHENYL)-1-ETHANONE
CBNumber
CB7367876
Molecular Formula
C8H5Cl3O
Formula Weight
223.48
MOL File
42981-08-8.mol
More
Less

2,3',4'-TRICHLOROACETOPHENONE Property

Melting point:
46-47°C
Boiling point:
171-173°C 15mm
Density 
1.430±0.06 g/cm3(Predicted)
Flash point:
171-173°C/15mm
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in methanol.
form 
powder to crystal
color 
White to Almost white
CAS DataBase Reference
42981-08-8(CAS DataBase Reference)
More
Less

Safety

Risk Statements 
34
Safety Statements 
36/37/39
RIDADR 
1759
HazardClass 
8
PackingGroup 
III
HS Code 
2914390090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
T1965
Product name
2,3',4'-Trichloroacetophenone
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$26
Updated
2025/07/31
TRC
Product number
B585903
Product name
2,3'',4''-Trichloroacetophenone
Packaging
50mg
Price
$50
Updated
2021/12/16
TRC
Product number
B585903
Product name
2,3'',4''-Trichloroacetophenone
Packaging
100mg
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
2617-5-03
Product name
3,4-Dichlorophenacyl chloride
Purity
98.00%
Packaging
5G
Price
$39
Updated
2021/12/16
Matrix Scientific
Product number
138716
Product name
2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
More
Less

2,3',4'-TRICHLOROACETOPHENONE Chemical Properties,Usage,Production

Uses

2,3',4'-Trichloroacetophenone is used as an organic chemical synthesis intermediate.

Synthesis

79-04-9

95-50-1

42981-08-8

General method: 1,2-Dichlorobenzene (50 g, 340 mmol) was mixed with anhydrous AlCl3 (45.354 g, 340 mmol) and heated to 70 °C. The mixture was then heated to 70 °C. The reaction was followed by the addition of 3-chloropropionyl chloride (47.506 g, 374 mmol). Subsequently, 3-chloropropionyl chloride (47.506 g, 374 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously at 70 °C for 6 hours. After the reaction was completed, it was cooled to room temperature and diluted with dichloromethane (300 mL). The diluted mixture was slowly poured into ice water (200 mL) and stirred for 30 minutes. The organic layer was separated, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/50, V/V) to afford the target product 2,3',4'-trichloroacetophenone (compound 2a) as a white solid (64.6 g, 80% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 24, p. 5420 - 5423
[2] Quarterly Journal of Pharmacy and Pharmacology, 1932, vol. 5, p. 500
[3] Chem. Zentralbl., 1933, vol. 104, # I, p. 605
[4] Roczniki Chemii, 1933, vol. 13, p. 293,295
[5] Chem. Zentralbl., 1933, vol. 104, # II, p. 1516

2,3',4'-TRICHLOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,3',4'-TRICHLOROACETOPHENONE Suppliers

China 54 Europe 3 France 1 Germany 2 India 4 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 4 United Kingdom 4 United States 14 Global 89
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
Nantong Chem-Tech.(Group) Co., Ltd
Tel
--
Fax
--
Email
ni.trade@pub.nt.jsinfo.net
Country
Europe
ProdList
1811
Advantage
56

42981-08-8, 2,3',4'-TRICHLOROACETOPHENONERelated Search:

2,2',4'-Trichloroacetophenone 224-trichloroacetophenone (intermediate of ketoconazole) 2',3',3'-TRICHLOROACETOPHENONE 2,3,4-TRICHLOROACETOPHENONE,2',3',4'-TRICHLOROACETOPHENONE P-TERT-BUTYL-2,2,2-TRICHLOROACETOPHENONE 2',4',5'-Trichloroacetophenone 4'-(3-Amino-1H-pyrazol-4-yl)-α,α,α-trichloroacetophenone,4'-(3-Amino-1H-pyrazol-4-yl)-ω,ω,ω-trichloroacetophenone α-Bromo-2',3',4'-trichloroacetophenone 2,2,2-trichloroacetophenone 2,2,2',4',5'-PENTACHLOROACETOPHENONE AURORA KA-3275 AURORA KA-4735 AURORA KA-3554 AKOS B024909 AURORA KA-3669 2,3',4'-TRICHLOROACETOPHENONE

  • 3,4-DICHLOROPHENACYL CHLORIDE
  • 1-ETHANONE, 2-CHLORO-1-(3,4-DICHLOROPHENYL)-
  • 2-CHLORO-1-(3,4-DICHLOROPHENYL)-1-ETHANONE
  • 2-CHLORO-1-(3,4-DICHLORO-PHENYL)-ETHANONE
  • 2-chloro-3-4-dichloroacetophenone
  • 2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one, 2,3',4'-Trichloroacetophenone
  • 3,4-Dichlorophenacyl chloride 95%
  • 2-Chloro-1-(3,4-dichlorophenyl)
  • 2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one
  • Ethanone, 2-chloro-1-(3,4-dichlorophenyl)-
  • 3,4-Dichloro-a-chloroacetophenone
  • 2,3',4'-TRICHLOROACETOPHENONE
  • 2,3′,4′-Trichloroacetophenone, CAS 42981-08-8
  • 42981-08-8