2-Acetylphenothiazine

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2-Acetylphenothiazine

Product Name: 2-Acetylphenothiazine
CAS No.: 6631-94-3
Chemical Name: 2-Acetylphenothiazine
Synonyms: 2-APT;ML 171;2-Acetylphenothiazin;2-ACETYLPHENOTHIAZINE;NOX1 Inhibitor, ML171;LABOTEST-BB LT00012652;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazine(ML171);methyl phenothiazin-2-yl ketone;Ethanone, 1-(10H-phenothiazin-2-yl)-
CBNumber: CB7368424
Molecular Formula: C14H11NOS
Formula Weight: 241.31
MOL File: 6631-94-3.mol

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2-Acetylphenothiazine Property

Melting point:: 180-185 °C (lit.)
Boiling point:: 455.7±34.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: -2.45±0.20(Predicted)
form: Dark yellow-orange powder
color: Yellow to Dark Orange
λmax: 244nm(MeOH)(lit.)
CAS DataBase Reference: 6631-94-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-52/53
Safety Statements: 60-61
WGK Germany: 3
HS Code: 2934309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 175226
Product name: 2-Acetylphenothiazine
Purity: 95%
Packaging: 25g
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: 175226
Product name: 2-Acetylphenothiazine
Purity: 95%
Packaging: 100g
Price: $319.2
Updated: 2024/03/01

TCI Chemical

Product number: A2815
Product name: 2-Acetylphenothiazine
Purity: >98.0%(GC)
Packaging: 5g
Price: $197
Updated: 2024/03/01

TCI Chemical

Product number: A2815
Product name: 2-Acetylphenothiazine
Purity: >98.0%(GC)
Packaging: 25g
Price: $572
Updated: 2024/03/01

Cayman Chemical

Product number: 19056
Product name: 2-Acetylphenothiazine
Purity: ≥98%
Packaging: 10g
Price: $32
Updated: 2024/03/01

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2-Acetylphenothiazine Chemical Properties,Usage,Production

Description

2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC₅₀ value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC₅₀ = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.

Chemical Properties

Yellow white or green crystalline powder

Uses

2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

Uses

2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives.

Definition

ChEBI: 1-(10H-phenothiazin-2-yl)ethanone is a member of phenothiazines.

2-Acetylphenothiazine Preparation Products And Raw materials

Raw materials

Preparation Products

ACETOPHENAZINE MALEATE (200 MG)

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View Lastest Price from 2-Acetylphenothiazine manufacturers

Career Henan Chemical Co

Product: 2-Acetylphenothiazine 6631-94-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

6631-94-3, 2-Acetylphenothiazine Related Search:

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2-ACETYLPHENOTHIAZINE

methyl phenothiazin-2-yl ketone

2-Acetyl-10H-phenothiazine

2-Acetylphenothiazin

1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine

ML 171

LABOTEST-BB LT00012652

NOX1 Inhibitor, ML171

2-Acetylphenothiazine(ML171)

NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem

2-APT

Ethanone, 1-(10H-phenothiazin-2-yl)-

6631-94-3

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