SB 218795

Product Name: SB 218795
CAS No.: 174635-53-1
Chemical Name: SB 218795
Synonyms: T23316;SB 218795;Sb 218795r;SB 218795, 10 mM in DMSO;Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate;methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate;(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide;(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE;(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID;Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)-
CBNumber: CB7376630
Molecular Formula: C25H20N2O3
Formula Weight: 396.44
MOL File: 174635-53-1.mol

More

Less

SB 218795 Property

Boiling point:: 623.7±55.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 40 mg/mL, soluble
form: solid
pka: 11.41±0.46(Predicted)
color: white

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 1376
Product name: SB218795
Purity: ≥99%(HPLC)
Packaging: 10
Price: $174
Updated: 2021/12/16

Tocris

Product number: 1376
Product name: SB218795
Purity: ≥99%(HPLC)
Packaging: 50
Price: $713
Updated: 2021/12/16

TRC

Product number: S155070
Product name: SB218795
Packaging: 50mg
Price: $865
Updated: 2021/12/16

ApexBio Technology

Product number: B6710
Product name: SB218795
Packaging: 10mg
Price: $329
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007579
Product name: SB 218795
Purity: 95.00%
Packaging: 10MG
Price: $721.59
Updated: 2021/12/16

More

Less

SB 218795 Chemical Properties,Usage,Production

Uses

SB 218795 is an NK3 receptor antagonist.

Definition

ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.

Biological Activity

Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.

in vivo

SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%^[2].

IC 50

hNK3: 13 nM (Ki); hNK2: 1220 nM (Ki)

SB 218795 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SB 218795 Suppliers

China 34 Germany 1 Switzerland 1 United Kingdom 1 United States 5 Global 42

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1010
Advantage: 58

174635-53-1, SB 218795Related Search:

CHEMBRDG-BB 9071014 SB 218795 N-(2-HYDROXYETHYL)ISONICOTINAMIDE, 99 FOR-D-PHG-OH N-METHYL-1-QUINOLIN-4-YLMETHANAMINE N-ME-D-PHG-OH 2-methylquinoline-4-carboxamide D(-)-AC-ALPHA-PHENYLGLYCINOL

SB 218795

(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE

(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID

(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide

Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-

Sb 218795r

methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate

constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3

Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)-

Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate

SB 218795, 10 mM in DMSO

T23316

174635-53-1