Bromonitromethane
- Product Name
- Bromonitromethane
- CAS No.
- 563-70-2
- Chemical Name
- Bromonitromethane
- Synonyms
- 255858_ALDRICH;EINECS 209-258-0;bromonitro-methan;nitrobromomethane;BROMONITROMETHANE;Nitromethyl bromide;Methane, bromonitro-;Bromonitromethane, tech.;bromonitromethane CH2BrNO2;Bromonitromethane, 90%,tech.
- CBNumber
- CB7381067
- Molecular Formula
- CH2BrNO2
- Formula Weight
- 139.94
- MOL File
- 563-70-2.mol
Bromonitromethane Property
- Melting point:
- -28 °C
- Boiling point:
- 146-148 °C/750 mmHg (lit.)
- Density
- 2.007 g/mL at 25 °C (lit.)
- refractive index
- 1.485-1.495
- Flash point:
- 4°C
- solubility
- Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slig
- pka
- 7.22±0.29(Predicted)
- form
- Liquid
- color
- Clear yellow
- Stability:
- Light Sensitive, Volatile
- CAS DataBase Reference
- 563-70-2(CAS DataBase Reference)
- EPA Substance Registry System
- Methane, bromonitro- (563-70-2)
Safety
- Hazard Codes
- Xn-O,Xi,O
- Risk Statements
- 8-36/37/38-20/21/22
- Safety Statements
- 36/37/39-26-17-36
- RIDADR
- 3098
- WGK Germany
- 3
- RTECS
- PA5360000
- HazardClass
- 5.1
- PackingGroup
- III
- HS Code
- 29049095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H272May intensify fire; oxidizer
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 255858
- Product name
- Bromonitromethane
- Purity
- technical grade, 90%
- Packaging
- 1g
- Price
- $71.4
- Updated
- 2024/03/01
- Product number
- 255858
- Product name
- Bromonitromethane
- Purity
- technical grade, 90%
- Packaging
- 10g
- Price
- $154
- Updated
- 2024/03/01
- Product number
- B686205
- Product name
- Bromonitromethane
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FB75111
- Product name
- Bromonitromethane
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB75111
- Product name
- Bromonitromethane
- Packaging
- 25g
- Price
- $400
- Updated
- 2021/12/16
Bromonitromethane Chemical Properties,Usage,Production
Chemical Properties
Bromonitromethane is a clear yellow liquid, It is a strong oxidizing agent with properties similar to nitromethane.
Bromonitromethane has been used:
in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis.
in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction.
in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy.
Uses
Bromonitromethane has received considerable attention as a one-carbon synthon for the synthesis of a variety of important organic intermediates.
Bromonitromethane is a key starting material for the preparation of the broad-spectrum antibiotic trovafloxacin, which contains the interesting 3-azabicyclo[ 3.1.0]hexane ring system.
it was used in the synthesis of 2-nitrobenzofuran and 2-nitro-2,3-dihydrobenzofuran-3-ols, nitrobenzothio-phenes, and nitrothiazoles, polyfunctionalized nitrocyclopropanes. It has also been utilized in the synthesis of 1-bromo-1-nitroalkan-2-ols and aryl nitromethanes. In addition, it could be used as a bromine donor.
Uses
Bromonitromethane has been used:
- in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis
- in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction
- in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy
Preparation
Bromonitromethane is commercially available and can also be easily prepared according to the procedures reported by Fishwick et al. A typical procedure is as following: freshly distilled nitromethane was stirred at 0℃ and bromine was dropped in 5 seconds. The resulted bromonitromethane could be used without further purification.
Bromonitromethane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bromonitromethane manufacturers
- Product
- BROMONITROMETHANE 563-70-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03