ChemicalBook > CAS DataBase List > 3-CHLORO-2-FLUORONITROBENZENE

3-CHLORO-2-FLUORONITROBENZENE

Product Name
3-CHLORO-2-FLUORONITROBENZENE
CAS No.
2106-49-2
Chemical Name
3-CHLORO-2-FLUORONITROBENZENE
Synonyms
5-Chloro-2-fluoroaniline;1-CHLORO-2-FLUORO-3-NITRO-BENZENE;3-chioro-2-fluoronitrobenzene;2-Fluoro-3-nitrochlorobenzene;3-CHLORO-2-FLUORONITROBENZENE;2-FLUORO-3-CHLORO-NITROBENZENE;3-Chloro-2-fluoro-1-nitrobenzene;3-CHLORO-2-FLUORONITROBENZENE,99%;Benzene, 1-chloro-2-fluoro-3-nitro-;1-Chloro-2-fluoro-3-nitrobenzene,97%
CBNumber
CB7384301
Molecular Formula
C6H3ClFNO2
Formula Weight
175.54
MOL File
2106-49-2.mol
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3-CHLORO-2-FLUORONITROBENZENE Property

Melting point:
36-40
Boiling point:
106 °C(Press: 5 Torr)
Density 
1.494±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
color 
Yellow
Water Solubility 
Soluble in water.
CAS DataBase Reference
2106-49-2(CAS DataBase Reference)
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Safety

Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
2810
Hazard Note 
Harmful
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C585060
Product name
1-Chloro-2-fluoro-3-nitrobenzene
Packaging
2.5g
Price
$65
Updated
2021/12/16
TRC
Product number
C585060
Product name
1-Chloro-2-fluoro-3-nitrobenzene
Packaging
500mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021502
Product name
3-CHLORO-2-FLUORO-1-NITROBENZENE
Purity
95.00%
Packaging
25G
Price
$1819.13
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021502
Product name
3-CHLORO-2-FLUORO-1-NITROBENZENE
Purity
95.00%
Packaging
1G
Price
$664.13
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021502
Product name
3-CHLORO-2-FLUORO-1-NITROBENZENE
Purity
95.00%
Packaging
5G
Price
$1010.63
Updated
2021/12/16
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3-CHLORO-2-FLUORONITROBENZENE Chemical Properties,Usage,Production

Uses

1-Chloro-2-fluoro-3-nitrobenzene is used as pharmaceutical intermediates, agrochemical intermediates, intermediates of medicine.

Synthesis

3209-22-1

2106-49-2

General procedure for the synthesis of 3-chloro-2-fluoronitrobenzene from 2,3-dichloronitrobenzene: 500 g (2.08 mol) of 2,3-dichloronitrobenzene was added to a four-necked flask fitted with a stirrer, a thermometer, and a condenser tube, and heated to 140 °C. Subsequently, 112 g (1.93 mol) of potassium fluoride (KF) was added to the reaction system, subjected to a decompression dehydration operation and held at 140-150 °C for 3 hours. After dehydration was completed, the temperature of the reaction system was raised to 140 °C, and then 6.6 g (0.06 mol) of tetramethylammonium chloride was slowly added between 150 and 160 °C. After the addition was completed, the reaction temperature was adjusted to 165±5°C and the reaction was continued for 8 hours. At the end of the reaction, the heating was stopped and the reaction mixture was allowed to cool to room temperature and washed with deionized water. The organic phase was separated and layered by distillation to recover 100 g of unreacted 2,3-dichloronitrobenzene, and finally 240 g of the target product 3-chloro-2-fluoronitrobenzene was obtained, which had a purity of 99.6% and a yield of 87.6%.

References

[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0015; 0039-0040
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 10, p. 1516 - 1529
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Patent: US5476976, 1995, A
[5] Patent: US5545768, 1996, A

3-CHLORO-2-FLUORONITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2-FLUORONITROBENZENE Suppliers

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View Lastest Price from 3-CHLORO-2-FLUORONITROBENZENE manufacturers

Anhui Zhongda Biotechnology Co., Ltd
Product
3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100T
Release date
2023-10-31
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
3-CHLORO-2-FLUORONITROBENZENE 2106-49-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-25

2106-49-2, 3-CHLORO-2-FLUORONITROBENZENERelated Search:

3-CHLORO-4-FLUORO-5-NITROBENZOTRIFLUORIDE 3-CHLORO-2,4-DIFLUORONITROBENZENE (3-CHLORO-4-FLUORO-5-NITRO)BENZENEBORONIC ACID 3-CHLORO-2-FLUORONITROBENZENE 2,4-Difluoro-3,5-dichloronitrobenzene 3-CHLORO-4-FLUORONITROBENZENE,3-Chloro-4-fluoronitrobenzene98%,3-Chloro-4-fluoronitrobenzene 98% 2,6-DIFLUOROPHENYLACETONITRILE 1-chloro-3-fluoro-5-nitro benzene 5-CHLORO-2-FLUORONITROBENZENE 2-CHLORO-6-FLUORONITROBENZENE 4-CHLORO-2-FLUORONITROBENZENE,4-Chloro-5-fluoronitrobenzene,4-CHLORO-2-FLUORONITROBENZENE 95+% 2-CHLORO-4-FLUORONITROBENZENE,2-CHLORO-4-FLUORONITROBENZENE 98% 1,2-DICHLORO-4-FLUORO-5-NITROBENZENE 4-CHLORO-3-FLUORONITROBENZENE 2,4-Dichloro-5-fluoronitrobenzene 2-Chloro-5-fluoronitrobenzene 99%,2-Chloro-5-fluoronitrobenzene99%,2-CHLORO-5-FLUORONITROBENZENE 2-CHLORO-3-FLUORONITROBENZENE 2-AMINO-3-CHLORO-4-FLUORONITROBENZENE

  • 3-CHLORO-2-FLUORONITROBENZENE
  • 2-FLUORO-3-CHLORO-NITROBENZENE
  • 3-CHLORO-2-FLUORONITROBENZENE / 1-CHLORO-2-FLUORO-3-NITROBENZENE
  • 2-Fluoro-3-nitrochlorobenzene
  • Benzene, 1-chloro-2-fluoro-3-nitro-
  • 3-Chloro-2-fluoro-1-nitrobenzene
  • 5-Chloro-2-fluoroaniline
  • 1-CHLORO-2-FLUORO-3-NITRO-BENZENE
  • 3-chioro-2-fluoronitrobenzene
  • 1-Chloro-2-fluoro-3-nitrobenzene,97%
  • 3-CHLORO-2-FLUORONITROBENZENE ISO 9001：2015 REACH
  • 3-CHLORO-2-FLUORONITROBENZENE,99%
  • 2106-49-2
  • FC6H3ClNO2
  • Fluorine series