2-Chloro-3-fluoronitrobenzene
- Product Name
- 2-Chloro-3-fluoronitrobenzene
- CAS No.
- 21397-07-9
- Chemical Name
- 2-Chloro-3-fluoronitrobenzene
- Synonyms
- 2-CHLORO-3-FLUORONITROBENZENE;1-Nitro-2-chloro-3-fluorobenzene;2-CHLORO-1-FLUORO-3-NITRO-BENZENE;1-CHLORO-2-FLUORO-6-NITRO-BENZENE;Benzene, 2-chloro-1-fluoro-3-nitro-;2-Chloro-3-fluoronitrobenzene CAS NO.21397-07-9;2-Chloro-3-fluoronitrobenzene ISO 9001：2015 REACH
- CBNumber
- CB4293246
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 21397-07-9.mol
2-Chloro-3-fluoronitrobenzene Property
- Boiling point:
- 237-239 °C
- Density
- 1.494±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- low melting solid
- color
- Brown
- CAS DataBase Reference
- 21397-07-9(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585065
- Product name
- 2-Chloro-3-fluoronitrobenzene
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W4442
- Product name
- 1-chloro-2-fluoro-6-nitrobenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 074119
- Product name
- 2-Chloro-3-fluoronitrobenzene
- Purity
- 95+%
- Packaging
- 5g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 4654-7-20
- Product name
- 2-Chloro-3-fluoronitrobenzene
- Packaging
- 5G
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 074119
- Product name
- 2-Chloro-3-fluoronitrobenzene
- Purity
- 95+%
- Packaging
- 10g
- Price
- $175
- Updated
- 2021/12/16
2-Chloro-3-fluoronitrobenzene Chemical Properties,Usage,Production
Uses
2-Chloro-3-fluoronitrobenzene can be used in substitution reactions to prepare other organic heterocyclic compounds. Its derivatives are also used as raw materials for the synthesis of aromatic polyimides.
Synthesis
402-67-5
21397-07-9
General procedure for the synthesis of 2-chloro-3-fluoronitrobenzene from 3-fluoronitrobenzene: To a solution of 3-fluoronitrobenzene (2 g, 14.2 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added a solution of N-chlorosuccinimide (5.69 g, 42.6 mmol) in THF (20 mL) at -78 °C. Subsequently, NaHMDS (28.4 mL, 28.4 mmol) in a 1 M solution of THF was added dropwise while ensuring that the internal temperature of the reaction system was maintained below -75 °C. The reaction mixture was stirred continuously at -78 °C for 30 min. Upon completion of the reaction, the mixture was partitioned between 5% hydrochloric acid and ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent evaporated. The resulting solid was purified by silica gel column chromatography with the eluent being a hexane solution of 20% ethyl acetate, resulting in the target product 2-chloro-3-fluoronitrobenzene (231 mg, 9.2% yield). The structure of the product was confirmed by EI-MS, m/z 176.5 (M+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3365 - 3369
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US6500863, 2002, B1
[4] Patent: US6500863, 2002, B1
2-Chloro-3-fluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-fluoronitrobenzene manufacturers
- Product
- 2-Chloro-3-fluoronitrobenzene 21397-07-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 2-Chloro-3-fluoronitrobenzene 21397-07-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12