ChemicalBook > CAS DataBase List > 2-Chloro-3-fluoronitrobenzene

2-Chloro-3-fluoronitrobenzene

Product Name
2-Chloro-3-fluoronitrobenzene
CAS No.
21397-07-9
Chemical Name
2-Chloro-3-fluoronitrobenzene
Synonyms
2-CHLORO-3-FLUORONITROBENZENE;1-Nitro-2-chloro-3-fluorobenzene;2-CHLORO-1-FLUORO-3-NITRO-BENZENE;1-CHLORO-2-FLUORO-6-NITRO-BENZENE;Benzene, 2-chloro-1-fluoro-3-nitro-;2-Chloro-3-fluoronitrobenzene CAS NO.21397-07-9;2-Chloro-3-fluoronitrobenzene ISO 9001：2015 REACH
CBNumber
CB4293246
Molecular Formula
C6H3ClFNO2
Formula Weight
175.54
MOL File
21397-07-9.mol
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2-Chloro-3-fluoronitrobenzene Property

Boiling point:
237-239 °C
Density 
1.494±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
low melting solid
color 
Brown
CAS DataBase Reference
21397-07-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C585065
Product name
2-Chloro-3-fluoronitrobenzene
Packaging
250mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
W4442
Product name
1-chloro-2-fluoro-6-nitrobenzene
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
074119
Product name
2-Chloro-3-fluoronitrobenzene
Purity
95+%
Packaging
5g
Price
$117
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-7-20
Product name
2-Chloro-3-fluoronitrobenzene
Packaging
5G
Price
$138
Updated
2021/12/16
Matrix Scientific
Product number
074119
Product name
2-Chloro-3-fluoronitrobenzene
Purity
95+%
Packaging
10g
Price
$175
Updated
2021/12/16
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2-Chloro-3-fluoronitrobenzene Chemical Properties,Usage,Production

Uses

2-Chloro-3-fluoronitrobenzene can be used in substitution reactions to prepare other organic heterocyclic compounds. Its derivatives are also used as raw materials for the synthesis of aromatic polyimides.

Synthesis

402-67-5

21397-07-9

General procedure for the synthesis of 2-chloro-3-fluoronitrobenzene from 3-fluoronitrobenzene: To a solution of 3-fluoronitrobenzene (2 g, 14.2 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added a solution of N-chlorosuccinimide (5.69 g, 42.6 mmol) in THF (20 mL) at -78 °C. Subsequently, NaHMDS (28.4 mL, 28.4 mmol) in a 1 M solution of THF was added dropwise while ensuring that the internal temperature of the reaction system was maintained below -75 °C. The reaction mixture was stirred continuously at -78 °C for 30 min. Upon completion of the reaction, the mixture was partitioned between 5% hydrochloric acid and ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent evaporated. The resulting solid was purified by silica gel column chromatography with the eluent being a hexane solution of 20% ethyl acetate, resulting in the target product 2-chloro-3-fluoronitrobenzene (231 mg, 9.2% yield). The structure of the product was confirmed by EI-MS, m/z 176.5 (M+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3365 - 3369
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US6500863, 2002, B1
[4] Patent: US6500863, 2002, B1

2-Chloro-3-fluoronitrobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-3-fluoronitrobenzene manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-3-fluoronitrobenzene 21397-07-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.1%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
2-Chloro-3-fluoronitrobenzene 21397-07-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

21397-07-9, 2-Chloro-3-fluoronitrobenzeneRelated Search:

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  • 2-Chloro-3-fluoronitrobenzene ISO 9001：2015 REACH
  • 2-Chloro-3-fluoronitrobenzene CAS NO.21397-07-9
  • 21397-07-9
  • 1397-07-9
  • Multisubstituted Benzene
  • Aromatic Halides (substituted)
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