ChemicalBook > CAS DataBase List > BMY 7378 DIHYDROCHLORIDE

BMY 7378 DIHYDROCHLORIDE

Product Name
BMY 7378 DIHYDROCHLORIDE
CAS No.
21102-95-4
Chemical Name
BMY 7378 DIHYDROCHLORIDE
Synonyms
CS-1419;BMY7378 HCl;BMY73782HCl;BMY 7378, >=98%;BMY7378;BMY-7378;BMY 7378 2hydrochloride;BMY 7378 DIHYDROCHLORIDE;8-(2-(4-(2-Methoxyphenyl);BMY7378,BMY-7378 dihydrochloride;BMY 7378 DIHYDROCHLORIDE;BMY 7378
CBNumber
CB7388662
Molecular Formula
C22H32ClN3O3
Formula Weight
421.97
MOL File
21102-95-4.mol
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BMY 7378 DIHYDROCHLORIDE Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: soluble
form 
solid
color 
white
Water Solubility 
Soluble to 100 mM in water
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Safety

WGK Germany 
3
RTECS 
GY3996000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B134
Product name
BMY 7378 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$304
Updated
2024/03/01
Sigma-Aldrich
Product number
B134
Product name
BMY 7378 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
100mg
Price
$899
Updated
2023/01/07
Cayman Chemical
Product number
21369
Product name
BMY 7378
Purity
≥98%
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21369
Product name
BMY 7378
Purity
≥98%
Packaging
25mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
21369
Product name
BMY 7378
Purity
≥98%
Packaging
50mg
Price
$140
Updated
2024/03/01
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BMY 7378 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist.

Biological Activity

5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.

storage

Room temperature

References

1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40.

BMY 7378 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BMY 7378 DIHYDROCHLORIDE Suppliers

China 66 Europe 1 Germany 3 India 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 17 Global 94
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21102-95-4, BMY 7378 DIHYDROCHLORIDERelated Search:

Glutarimide 3,3-DIMETHYLGLUTARIMIDE 1-(2-Methoxyphenyl)piperazine BMY 7378 DIHYDROCHLORIDE 3-ETHYL-3-METHYLGLUTARIMIDE 1-(2-HYDROXYPHENYL)PIPERAZINE 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE 3,3-Tetramethyleneglutarimide 1-(2-Methoxyphenyl)piperazine hydrochloride 1-(2-Methoxyphenyl)piperazine hydrobromide 1-(4-CHLOROBENZYL)PIPERAZINE 4,4-DIETHYLPIPERIDINE 1-(2-PIPERIDINOETHYL)PIPERAZINE 8-AZASPIRO[4.5]DECANE 2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE 1-(2-DIETHYLAMINOETHYL)PIPERAZINE N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 3-methylglutarimide

  • BMY 7378 2hydrochloride
  • BMY 7378 DIHYDROCHLORIDE;BMY 7378
  • 8-(2-(4-(2-Methoxyphenyl)
  • -8-azaspiro[4.5]decane-7,9-dione dihydrochloride
  • BMY7378 HCl
  • 1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d
  • n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimided
  • BMY 7378 DIHYDROCHLORIDE >98% PARTIAL 5- HT1A SEROTO
  • BMY73782HCl
  • 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride BMY7378
  • BMY 7378, >=98%
  • 8-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE DIHYDROCHLORIDE
  • 8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4.5)DECANE-7,9-DIONE DIHYDROCHLORIDE
  • BMY 7378 DIHYDROCHLORIDE
  • BMY7378;BMY-7378
  • CS-1419
  • 1,1-Cyclopentanediacetimide, N-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride
  • BMY 7378 DIHYDROCHLORIDE;8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4,5)DECANE-7,9-DIONE DIHYDROCHLORIDE
  • N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
  • 8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
  • BMY 7378 DIHYDROCHLORIDE USP/EP/BP
  • 8-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-8-azaspiro[4....
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride (1:2)
  • BMY7378,BMY-7378 dihydrochloride
  • BMY 7378 dihydrochloride, 5-HT1A partial agonist. alpha adrenoceptor antagonist.
  • 21102-95-4
  • C22H33Cl2N3O3
  • C22H31N3O32HCl
  • Serotonin receptor
  • Inhibitors