BMY 7378 DIHYDROCHLORIDE
- Product Name
- BMY 7378 DIHYDROCHLORIDE
- CAS No.
- 21102-95-4
- Chemical Name
- BMY 7378 DIHYDROCHLORIDE
- Synonyms
- CS-1419;BMY7378 HCl;BMY73782HCl;BMY 7378, >=98%;BMY7378;BMY-7378;BMY 7378 2hydrochloride;BMY 7378 DIHYDROCHLORIDE;8-(2-(4-(2-Methoxyphenyl);BMY7378,BMY-7378 dihydrochloride;BMY 7378 DIHYDROCHLORIDE;BMY 7378
- CBNumber
- CB7388662
- Molecular Formula
- C22H32ClN3O3
- Formula Weight
- 421.97
- MOL File
- 21102-95-4.mol
BMY 7378 DIHYDROCHLORIDE Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- H2O: soluble
- form
- solid
- color
- white
- Water Solubility
- Soluble to 100 mM in water
Safety
- WGK Germany
- 3
- RTECS
- GY3996000
N-Bromosuccinimide Price
- Product number
- B134
- Product name
- BMY 7378 dihydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $304
- Updated
- 2024/03/01
- Product number
- B134
- Product name
- BMY 7378 dihydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 100mg
- Price
- $899
- Updated
- 2023/01/07
- Product number
- 21369
- Product name
- BMY 7378
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21369
- Product name
- BMY 7378
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 21369
- Product name
- BMY 7378
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $140
- Updated
- 2024/03/01
BMY 7378 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist.
Biological Activity
5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ .
Biochem/physiol Actions
BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.
storage
Room temperature
References
1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40.
BMY 7378 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
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