BMY 7378 DIHYDROCHLORIDE

Product Name: BMY 7378 DIHYDROCHLORIDE
CAS No.: 21102-95-4
Chemical Name: BMY 7378 DIHYDROCHLORIDE
Synonyms: CS-1419;BMY7378 HCl;BMY73782HCl;BMY 7378, >=98%;BMY7378;BMY-7378;BMY 7378 2hydrochloride;BMY 7378 DIHYDROCHLORIDE;8-(2-(4-(2-Methoxyphenyl);BMY7378,BMY-7378 dihydrochloride;BMY 7378 DIHYDROCHLORIDE;BMY 7378
CBNumber: CB7388662
Molecular Formula: C22H32ClN3O3
Formula Weight: 421.97
MOL File: 21102-95-4.mol

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BMY 7378 DIHYDROCHLORIDE Property

storage temp.: Inert atmosphere,Room Temperature
solubility: H₂O: soluble
form: solid
color: white
Water Solubility: Soluble to 100 mM in water

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Safety

WGK Germany: 3
RTECS: GY3996000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B134
Product name: BMY 7378 dihydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $304
Updated: 2024/03/01

Sigma-Aldrich

Product number: B134
Product name: BMY 7378 dihydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 100mg
Price: $899
Updated: 2023/01/07

Cayman Chemical

Product number: 21369
Product name: BMY 7378
Purity: ≥98%
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21369
Product name: BMY 7378
Purity: ≥98%
Packaging: 25mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 21369
Product name: BMY 7378
Purity: ≥98%
Packaging: 50mg
Price: $140
Updated: 2024/03/01

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BMY 7378 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist.

Biological Activity

5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.

storage

Room temperature

References

1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40.

BMY 7378 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BMY 7378 DIHYDROCHLORIDE Suppliers

China 66 Europe 1 Germany 3 India 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 17 Global 94

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Nanjing Chemlin Chemical Co., Ltd

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Email: info@chemlin.com.cn
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Chengdu NoVi Biotechnology Co., Ltd.

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Fax: 028-81458053
Email: novibiotech@163.com sales@novi-biotech.com
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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AdooQ BioScience, LLC

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AdooQ Bioscience CHINA

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Hubei Jusheng Technology Co.,Ltd

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Fax: 027-59599241
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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21102-95-4, BMY 7378 DIHYDROCHLORIDERelated Search:

Glutarimide 3,3-DIMETHYLGLUTARIMIDE 1-(2-Methoxyphenyl)piperazine BMY 7378 DIHYDROCHLORIDE 3-ETHYL-3-METHYLGLUTARIMIDE 1-(2-HYDROXYPHENYL)PIPERAZINE 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE 3,3-Tetramethyleneglutarimide 1-(2-Methoxyphenyl)piperazine hydrochloride 1-(2-Methoxyphenyl)piperazine hydrobromide 1-(4-CHLOROBENZYL)PIPERAZINE 4,4-DIETHYLPIPERIDINE 1-(2-PIPERIDINOETHYL)PIPERAZINE 8-AZASPIRO[4.5]DECANE 2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE 1-(2-DIETHYLAMINOETHYL)PIPERAZINE N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 3-methylglutarimide

BMY 7378 2hydrochloride

BMY 7378 DIHYDROCHLORIDE;BMY 7378

8-(2-(4-(2-Methoxyphenyl)

-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

BMY7378 HCl

1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d

n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimided

BMY 7378 DIHYDROCHLORIDE >98% PARTIAL 5- HT1A SEROTO

BMY73782HCl

8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride BMY7378

BMY 7378, >=98%

8-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE DIHYDROCHLORIDE

8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4.5)DECANE-7,9-DIONE DIHYDROCHLORIDE

BMY 7378 DIHYDROCHLORIDE

BMY7378;BMY-7378

CS-1419

1,1-Cyclopentanediacetimide, N-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride

BMY 7378 DIHYDROCHLORIDE;8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4,5)DECANE-7,9-DIONE DIHYDROCHLORIDE

N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

BMY 7378 DIHYDROCHLORIDE USP/EP/BP

8-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-8-azaspiro[4....

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride (1:2)

BMY7378,BMY-7378 dihydrochloride

BMY 7378 dihydrochloride, 5-HT1A partial agonist. alpha adrenoceptor antagonist.

21102-95-4

C22H33Cl2N3O3

C22H31N3O32HCl

Serotonin receptor

Inhibitors