ChemicalBook > CAS DataBase List > Methyl 4-amino-3-iodobenzoate

Methyl 4-amino-3-iodobenzoate

Product Name: Methyl 4-amino-3-iodobenzoate
CAS No.: 19718-49-1
Chemical Name: Methyl 4-amino-3-iodobenzoate
Synonyms: Methyl 4-amino-3-;2-Iodo-4-carboMethoxyaniline;METHYL 4-AMINO-3-IODOBENZOATE;Methyl 4-amino-3-iodobenzozte;Methyle4-amino-3-iodobenzoate;Methyl 4-aMino-3-iodobenzoate 95% (GC);Benzoic acid, 4-amino-3-iodo-, methyl ester;Methyl 4-aMino-3-iodobenzoate;2-iodo-4-(methoxycarbonyl)aniline,methyl 4-amino-3-iodo-benzoate,4-methoxycarbonyl-2-iodoaniline,4-Amino-3-iodo-benzoic acid methyl ester
CBNumber: CB7390649
Molecular Formula: C8H8INO2
Formula Weight: 277.06
MOL File: 19718-49-1.mol

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Methyl 4-amino-3-iodobenzoate Property

Melting point:: 86-91 °C (lit.)
Boiling point:: 369.6±32.0 °C(Predicted)
Density: 1.826±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 0.41±0.10(Predicted)
form: Crystalline Powder
color: Beige
InChI: InChI=1S/C8H8INO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3
InChIKey: MRLVFVTVXSKAMX-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(N)C(I)=C1
CAS DataBase Reference: 19718-49-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 515183
Product name: Methyl 4-amino-3-iodobenzoate
Purity: 95% (GC)
Packaging: 5g
Price: $215
Updated: 2023/01/07

Sigma-Aldrich

Product number: 515183
Product name: Methyl 4-amino-3-iodobenzoate
Purity: 95% (GC)
Packaging: 25g
Price: $474
Updated: 2023/01/07

TCI Chemical

Product number: A3659
Product name: Methyl 4-Amino-3-iodobenzoate
Purity: min. 98.0 %
Packaging: 5G
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: A3659
Product name: Methyl 4-Amino-3-iodobenzoate
Purity: min. 98.0 %
Packaging: 25G
Price: $270
Updated: 2025/07/31

Usbiological

Product number: 455418
Product name: Methyl 4-Amino-3-
Packaging: 10mg
Price: $460
Updated: 2021/12/16

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Methyl 4-amino-3-iodobenzoate Chemical Properties,Usage,Production

Definition

ChEBI: Methyl 4-amino-3-iodobenzoate is a benzoate ester.

Synthesis

619-45-4

19718-49-1

General procedure for the synthesis of methyl 4-amino-3-iodobenzoate from methyl 4-aminobenzoate: dissolve methyl 4-aminobenzoate (5.0 g, 0.033 mol), benzyltrimethylammonium dichloroiodonate (22.1 g, 0.056 mol), and calcium carbonate (5.0 g, 0.050 mol) in a solvent mixture of dichloromethane (200 ml) and methanol (100 g). . The reaction mixture was heated to reflux overnight with stirring. Upon completion of the reaction, the solution was cooled to room temperature, washed with saturated sodium bisulfate solution, and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the crude product methyl 4-amino-3-iodobenzoate (9.6 g, quantitative yield), which was used in the subsequent reaction without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 3.75 (s, 3H), 6.09 (s, 2H), 6.75 (d, J = 8.59 Hz, 1H), 7.66 (dd, J = 8.59, 2.02 Hz, 1H), 8.11 (d, J = 2.02 Hz, 1H).

References

[1] Patent: WO2007/38331, 2007, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2007/103759, 2007, A2. Location in patent: Page/Page column 48
[3] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[4] European Journal of Organic Chemistry, 2001, # 24, p. 4607 - 4613
[5] Synlett, 2014, vol. 25, # 3, p. 399 - 402

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View Lastest Price from Methyl 4-amino-3-iodobenzoate manufacturers

Career Henan Chemical Co

Product: Methyl 4-amino-3-iodobenzoate 19718-49-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

19718-49-1, Methyl 4-amino-3-iodobenzoateRelated Search:

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Methyl 4-amino-3-iodobenzozte

METHYL 4-AMINO-3-IODOBENZOATE

Methyl 4-amino-3-

2-Iodo-4-carboMethoxyaniline

Methyl 4-<WBR>aMino-<WBR>3-<WBR>iodobenzoate

Methyl 4-aMino-3-iodobenzoate 95% (GC)

Methyle4-amino-3-iodobenzoate

Benzoic acid, 4-amino-3-iodo-, methyl ester

2-iodo-4-(methoxycarbonyl)aniline,methyl 4-amino-3-iodo-benzoate,4-methoxycarbonyl-2-iodoaniline,4-Amino-3-iodo-benzoic acid methyl ester

19718-49-1

H2NC6H3ICO2CH3

Building Blocks

Carbonyl Compounds

C8 to C9

Esters

Organic Building Blocks

Building Blocks

C8 to C9

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

API intermediates

C8 to C9

Carbonyl Compounds

Esters

Aromatic Esters