(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine

Product Name: (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
CAS No.: 662164-09-2
Chemical Name: (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
Synonyms: D3-βArr;D3-βArr;C 00379308;D3- beta Arr;NCGC00379308;D3-βArr?- NCg;D3-βArr- NCGC 00379308;D3-βArr, 10 mM in DMSO;D3-βArr?- NCGC 00379308;NCGC00379308 (D3-βArr )
CBNumber: CB73919157
Molecular Formula: C20H23N5
Formula Weight: 333.43
MOL File: 662164-09-2.mol

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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 125 mg/mL (374.89 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2256
Product name: D3-βArr
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $84.83
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2256
Product name: D3-βArr
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $287
Updated: 2025/07/31

ChemScene

Product number: CS-0088722
Product name: D3-βArr
Purity: 99.48%
Packaging: 50mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0088722
Product name: D3-βArr
Purity: 99.48%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0088722
Product name: D3-βArr
Purity: 99.48%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Chemical Properties,Usage,Production

Uses

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].

Biological Activity

D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling th at initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.

References

[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. DOI:10.1124/jpet.117.244095

(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Suppliers

China 25 Russia 1 United States 6 Global 32

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662164-09-2, (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amineRelated Search:

Chlorotrimethylsilane p-Anisidine 2-Methylfuran Hydroxyethyl piperazine N-Methyldiethanolamine

(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine

D3- beta Arr

D3-βArr

D3-βArr?- NCGC 00379308

NCGC00379308

C 00379308

D3-βArr?- NCg

4-Quinazolinamine, N-(1-phenylethyl)-2-(1-piperazinyl)-

D3-βArr- NCGC 00379308

D3-betaArr >=98% (HPLC)

NCGC00379308 (D3-βArr )

Thyroid-stimulating hormone Receptor,D3-βArr,Thyrotropin receptor,inhibit,D3βArr,TSH Receptor,Inhibitor,D-3-βArr,D3 βArr

N-(1-Phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine

D3-βArr?- NC C 00379308

D3-βArr, 10 mM in DMSO

D3-βArr

662164-09-2