(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
- Product Name
- (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
- CAS No.
- 662164-09-2
- Chemical Name
- (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
- Synonyms
- D3-βArr;D3-βArr;C 00379308;D3- beta Arr;NCGC00379308;D3-βArr?- NCg;D3-βArr- NCGC 00379308;D3-βArr, 10 mM in DMSO;D3-βArr?- NCGC 00379308;NCGC00379308 (D3-βArr )
- CBNumber
- CB73919157
- Molecular Formula
- C20H23N5
- Formula Weight
- 333.43
- MOL File
- 662164-09-2.mol
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 125 mg/mL (374.89 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2256
- Product name
- D3-βArr
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $84.83
- Updated
- 2025/07/31
- Product number
- SML2256
- Product name
- D3-βArr
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $287
- Updated
- 2025/07/31
- Product number
- CS-0088722
- Product name
- D3-βArr
- Purity
- 99.48%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0088722
- Product name
- D3-βArr
- Purity
- 99.48%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0088722
- Product name
- D3-βArr
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Chemical Properties,Usage,Production
Uses
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].
Biological Activity
D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling th at initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.
References
[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. DOI:10.1124/jpet.117.244095
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Preparation Products And Raw materials
Raw materials
Preparation Products
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Suppliers
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