1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE
- Product Name
- 1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE
- CAS No.
- 192189-07-4
- Chemical Name
- 1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE
- Synonyms
- 1-Boc-3-iodoindole;N-Boc-3-iodoindole;1-Boc-3-iodoindole, 95%;tert-butyl3-iodoindole-1-carboxylate;tert-butyl 3-iodo-1H-indol-1-carboxylate;1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE;1-(Tert-Butoxycarbonyl)-3-iodo-1H-icdole;tert-Butyl 3-iodo-1H-indole-1-carboxylate;3-Iodoindole-1-carboxylic acid tert-butyl ester;3-Iodo-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester
- CBNumber
- CB7395846
- Molecular Formula
- C13H14INO2
- Formula Weight
- 343.16
- MOL File
- 192189-07-4.mol
1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE Property
- Melting point:
- 36-40℃
- Boiling point:
- 388℃
- Density
- 1.56
- Flash point:
- 189℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light yellow to yellow <36°C Solid,>40°C Liquid
- Water Solubility
- Insoluble in water.
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C13H14INO2/c1-13(2,3)17-12(16)15-8-10(14)9-6-4-5-7-11(9)15/h4-8H,1-3H3
- InChIKey
- LOFWPZQNSUAMCV-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)C2=C(C=CC=C2)C(I)=C1
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- B699948
- Product name
- tert-Butyl3-Iodo-1H-indole-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB154376
- Product name
- tert-butyl3-iodoindole-1-carboxylate
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
- Product number
- FB154376
- Product name
- tert-butyl3-iodoindole-1-carboxylate
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
- Product number
- 4H56-H-25
- Product name
- 3-Iodoindole-1-carboxylic acid tert-butyl ester
- Purity
- 98%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FB154376
- Product name
- tert-butyl3-iodoindole-1-carboxylate
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE Chemical Properties,Usage,Production
Uses
1-Boc-3-iodoindole is used as a pharmaceutical intermediate and also used in ceramic manufacturing industry.
Synthesis
26340-47-6
24424-99-5
192189-07-4
In a dry reaction flask, 3-iodo-1H-indole (23.1 g, 95.05 mmol) was dissolved in dichloromethane (200 mL). Subsequently, triethylamine (24 g, 237.6 mmol) and di-tert-butyl dicarbonate (20.75 g, 95.07 mmol) were added sequentially to this solution. The reaction mixture was stirred at room temperature for 12 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the complete disappearance of the ingredients. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic phases were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by rotary evaporator to afford 1-Boc-3-iodoindole (27.7 g, 85% yield).
References
[1] Organic Letters, 2018, vol. 20, # 7, p. 1978 - 1981
[2] Journal of Organic Chemistry, 2008, vol. 73, # 17, p. 6706 - 6710
[3] Tetrahedron, 2000, vol. 56, # 43, p. 8473 - 8480
[4] Patent: CN104876914, 2017, B. Location in patent: Paragraph 0313-0315
[5] Patent: WO2017/173604, 2017, A1. Location in patent: Page/Page column 19; 20
1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE manufacturers
- Product
- 1-(TERT-BUTOXYCARBONYL)-3-IODO-1H-INDOLE 192189-07-4
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12