5-Methyl-2-hexanone Property

Melting point:

-74 °C

Boiling point:

145 °C (lit.)

Density 

0.814 g/mL at 25 °C (lit.)

vapor density 

3.94 (vs air)

vapor pressure 

4.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.406(lit.)

Flash point:

106 °F

storage temp. 

Store below +30°C.

solubility 

water: soluble5.4g/L at 25°C

form 

Liquid

color 

Clear colorless

Odor

pleasant odor

Odor Threshold

0.0021ppm

explosive limit

1.35-8.2%, 93°F

Water Solubility 

5.4 g/L (20 ºC)

BRN 

506163

Exposure limits

TLV-TWA 240 mg/m³ (50 ppm) (ACGIH).

LogP

1.88 at 25℃

CAS DataBase Reference

110-12-3(CAS DataBase Reference)

NIST Chemistry Reference

2-Hexanone, 5-methyl-(110-12-3)

EPA Substance Registry System

Methyl isoamyl ketone (110-12-3)

Safety

Hazard Codes 

Xn

Risk Statements 

10-20

Safety Statements 

23-24/25

RIDADR 

UN 2302 3/PG 3

OEB

A

OEL

TWA: 50 ppm (240 mg/m3)

WGK Germany 

1

RTECS 

MP3850000

Autoignition Temperature

797 °F

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29141910

Hazardous Substances Data

110-12-3(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 3200 mg/kg LD50 dermal Rabbit 8100 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

5-Methyl-2-hexanone Chemical Properties,Usage,Production

Description

MIAK is a colorless liquid with a pleasant,fruity odor. Molecular weight = 114.21; Specific gravity(H2O:1) 5 0.81; Boiling point = 144℃; Freezing/Meltingpoint 5 2 74℃; Vapor pressure 5 5 mmHg at 20℃; Flashpoint 5 36.1℃ (cc); Autoignition temperature 5 191℃.Explosive limits: LEL 5 1.0% at 93.3℃; UEL 5 8.2% at93.3℃. Hazard Identification (based on NFPA-704 MRating System): Health 1, Flammability 2, Reactivity 0.Slightly soluble in water; solubility 5 0.5%.

Chemical Properties

MIAK is a colorless liquid with a pleasant, fruity odor.

Uses

5-Methyl-2-hexanone is used as a solvent for the production of high-solids coatings, because it possesses a high solubility for alkyd resins, acrylic resins, cellulose esters, cellulose nitrate, and vinylic copolymers. 5-Methyl-2-hexanone may be used to synthesize N,N′-bis(1,4-dimethylpentyl)-p-phenylenediamine (BMPPD) via reductive alkylation of p-nitroaniline in the presence of copper-based catalysts.

Application

Methyl isoamyl ketone (MIAK) is used asa solvent for polymers, cellulose esters, nitrocellulose, cellulose acetatebutyrate, andacrylics, and vinyl copolymers.

Definition

ChEBI: 5-methyl-2-hexanone is a ketone.

Preparation

5-Methyl-2-hexanone is produced by condensation of acetone with isobutyraldehyde. This reaction may be carried out in one or two steps, in the liquid or in the gas phase.

General Description

5-methylhexan-2-one appears as a colorless liquid with a pleasant fruity odor. Less dense than water. Vapors heavier than air. Used as a solvent and for making other chemicals.

Air & Water Reactions

Flammable. Slightly soluble in water.

Reactivity Profile

Ketones, such as 5-Methyl-2-hexanone, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Hazard

Moderate fire risk. Central nervous systemimpairment and upper respiratory tract irritant.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Health Hazard

Exposure to MIAK can produce a strongnarcotic effect and irritation of the eyes andrespiratory tract. The oral toxicity, however,was found to be low in rats: 1670 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation and skin contact. A flammable liquid when exposed to heat, flame, or oxidzers. To fight fire, use dry chemical, CO2, foam, fog. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

MIAK is used as a solvent for cellulose esters, acrylics, and vinyl copolymers.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Store intightly closed containers in a cool, well-ventilated areaaway from oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates), strong oxidizers (suchas chlorine, bromine, and fluorine), reducing agents, andaldehydes. Sources of ignition, such as smoking and openflames, are prohibited where methyl isoamyl ketone is handled, used, or stored. Metal containers involving the transferof 5 gallons or more of methyl isoamyl ketone should begrounded and bonded. Drums must be equipped with selfclosing valves, pressure vacuum bungs, and flame arresters.

Shipping

UN23025-Methylhexan-2-one, Hazard Class: 3; Labels: 3-Flammable liquid.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates. Attacks some plastics and coatings

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.