CA-074
- Product Name
- CA-074
- CAS No.
- 134448-10-5
- Chemical Name
- CA-074
- Synonyms
- CA-074;CA-074（OH）;CA 074 TFA;CA-074 >=99% (TLC);CATHEPSIN B INHIBITOR III;INHIBITOR FOR CATHEPSIN B;L-trans-Epoxysuccinyl(propylamide)-Ile-Pro;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH;CA-074（L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide）
- CBNumber
- CB7400409
- Molecular Formula
- C18H29N3O6
- Formula Weight
- 383.44
- MOL File
- 134448-10-5.mol
CA-074 Property
- Boiling point:
- 728.9±60.0 °C(Predicted)
- Density
- 1.267±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.
- form
- solid
- pka
- 3.43±0.20(Predicted)
- color
- White to yellow
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C5732
- Product name
- CA-074
- Purity
- ≥99% (TLC)
- Packaging
- 5mg
- Price
- $503
- Updated
- 2024/03/01
- Product number
- 205530
- Product name
- CA-074
- Purity
- CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
- Packaging
- 1MG
- Price
- $259
- Updated
- 2024/03/01
- Product number
- J65347
- Product name
- Cathepsin B Inhibitor III
- Packaging
- 5mg
- Price
- $362
- Updated
- 2023/06/20
- Product number
- 24679
- Product name
- CA-074
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 24679
- Product name
- CA-074
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $176
- Updated
- 2024/03/01
CA-074 Chemical Properties,Usage,Production
Uses
CA-074 is a potent and specific inhibitor of cathepsin B in vitro.
Uses
Inhibitor of Cathepsin B.
Biological Activity
ca-074, a specific cathepsin b inhibitor, also abolished the neurotoxic effects caused by abeta42-activated bv2 cell [1]. co-treatment of cultures with the cathepsin b inhibitors ca-074 or z-fa-fmk suppressed the cytostatic effects of tpa and activation of pro-upa [2]. administration of ca-074 suppresses the response to exogenous antigens, such as hepatitis b virus antigen, ovalbumin and leishmania major antigen, and induces switching of the helper t cell responses from th-2 to th-1 of cd4+ t cell, thereby down regulating the production of ige and igg1 [3]. pharmacological inhibition of cat b in catb(+/+) mice with l-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-lisoleucyl-l-proline (ca-074 me) also reduced tnf-alpha-induced liver damage. [4] administration of cathepsin b inhibitors, e-64, ca-074 and vitamin b6, caused the strong suppression of the th-2 type immune responses .inhibitor of cathepsin b (ki = 2-5 nm). displays selectivity over cathepsins h and l (ki = 40-200 μm). shown to reduce bone metastasis in a 4t1.2 breast cancer model.
storage
Store at -20°C
References
1. identification of cathepsin b as a mediator of neuronal death induced by abeta-activated microglial cells using a functional genomics approach. gan, l., ye, s., chu, a., anton, k., yi, s., vincent, v.a., von schack, d., chin, d., murray, j., lohr, s., patthy, l., gonzalez-zulueta, m., nikolich, k., urfer, r. j. biol. chem. (2004) 2. phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betal a process initiated by the exocytosis of cathepsin b. guo, m., mathieu, p.a., linebaugh, b., sloane, b.f., reiners, j.j. j. biol. chem. (2002) 3. insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors. katunuma, n., matsunaga, y., himeno, k., hayashi, y. biol. chem. (2003) 4. cathepsin b knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. guicciardi, m.e., miyoshi, h., bronk, s.f., gores, g.j. am. j. pathol. (2001)
CA-074 Preparation Products And Raw materials
Raw materials
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View Lastest Price from CA-074 manufacturers
- Product
- CA-074 134448-10-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10