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CA-074

Product Name
CA-074
CAS No.
134448-10-5
Chemical Name
CA-074
Synonyms
CA-074;CA-074（OH）;CA 074 TFA;CA-074 >=99% (TLC);CATHEPSIN B INHIBITOR III;INHIBITOR FOR CATHEPSIN B;L-trans-Epoxysuccinyl(propylamide)-Ile-Pro;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH;CA-074（L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide）
CBNumber
CB7400409
Molecular Formula
C18H29N3O6
Formula Weight
383.44
MOL File
134448-10-5.mol
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CA-074 Property

Boiling point:
728.9±60.0 °C(Predicted)
Density 
1.267±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.
form 
solid
pka
3.43±0.20(Predicted)
color 
White to yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5732
Product name
CA-074
Purity
≥99% (TLC)
Packaging
5mg
Price
$503
Updated
2024/03/01
Sigma-Aldrich
Product number
205530
Product name
CA-074
Purity
CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
1MG
Price
$259
Updated
2024/03/01
Alfa Aesar
Product number
J65347
Product name
Cathepsin B Inhibitor III
Packaging
5mg
Price
$362
Updated
2023/06/20
Cayman Chemical
Product number
24679
Product name
CA-074
Purity
≥98%
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
24679
Product name
CA-074
Purity
≥98%
Packaging
1mg
Price
$176
Updated
2024/03/01
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CA-074 Chemical Properties,Usage,Production

Uses

CA-074 is a potent and specific inhibitor of cathepsin B in vitro.

Uses

Inhibitor of Cathepsin B.

Biological Activity

ca-074, a specific cathepsin b inhibitor, also abolished the neurotoxic effects caused by abeta42-activated bv2 cell [1]. co-treatment of cultures with the cathepsin b inhibitors ca-074 or z-fa-fmk suppressed the cytostatic effects of tpa and activation of pro-upa [2]. administration of ca-074 suppresses the response to exogenous antigens, such as hepatitis b virus antigen, ovalbumin and leishmania major antigen, and induces switching of the helper t cell responses from th-2 to th-1 of cd4+ t cell, thereby down regulating the production of ige and igg1 [3]. pharmacological inhibition of cat b in catb(+/+) mice with l-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-lisoleucyl-l-proline (ca-074 me) also reduced tnf-alpha-induced liver damage. [4] administration of cathepsin b inhibitors, e-64, ca-074 and vitamin b6, caused the strong suppression of the th-2 type immune responses .inhibitor of cathepsin b (ki = 2-5 nm). displays selectivity over cathepsins h and l (ki = 40-200 μm). shown to reduce bone metastasis in a 4t1.2 breast cancer model.

storage

Store at -20°C

References

1. identification of cathepsin b as a mediator of neuronal death induced by abeta-activated microglial cells using a functional genomics approach. gan, l., ye, s., chu, a., anton, k., yi, s., vincent, v.a., von schack, d., chin, d., murray, j., lohr, s., patthy, l., gonzalez-zulueta, m., nikolich, k., urfer, r. j. biol. chem. (2004) 2. phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betal a process initiated by the exocytosis of cathepsin b. guo, m., mathieu, p.a., linebaugh, b., sloane, b.f., reiners, j.j. j. biol. chem. (2002) 3. insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors. katunuma, n., matsunaga, y., himeno, k., hayashi, y. biol. chem. (2003) 4. cathepsin b knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. guicciardi, m.e., miyoshi, h., bronk, s.f., gores, g.j. am. j. pathol. (2001)

CA-074 Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-074 Suppliers

China 75 Germany 2 Japan 1 Switzerland 2 United Kingdom 2 United States 18 Global 100
Peptanova GmbH
Tel
--
Fax
--
Email
info@peptanova.de
Country
Germany
ProdList
3
Advantage
0
SERVA Electrophoresis GmbH
Tel
--
Fax
--
Email
info@serva.de
Country
Germany
ProdList
1142
Advantage
80
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View Lastest Price from CA-074 manufacturers

Career Henan Chemical Co
Product
CA-074 134448-10-5
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

134448-10-5, CA-074Related Search:

5 MG CA-074 ME, PROINH. FOR INTRACELLULARCATHEPSIN B MEMBRANE-PERMEABLE ANALOG OF CA-074 5 MG CA-074INHIBITOR FOR CATHEPSIN B CA-074 METHYL ESTER H-VAL-PRO-OH HCL CA-074 ME CA-074

  • N-(L-3-TRANS-PROPYLCARBAMOYL-OXIRANE-2-CARBONYL)-ILE-PRO-OH
  • L-trans-Epoxysuccinyl(propylamide)-Ile-Pro
  • N-(L-3-trans-PropylcarbaMoyl-oxirane-2-carbonyl)-Ile-Pro-OH, CA-074, L-trans-Epoxysuccinyl(propylaMide)-Ile-Pro-OH
  • INHIBITOR FOR CATHEPSIN B
  • CATHEPSIN B INHIBITOR III
  • CA-074
  • [L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE
  • (L-3-TRANS-(PROPYLCARBAMYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE
  • [L-3-TRANS-(PROPYLCARBOMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE
  • L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
  • L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH
  • N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
  • L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-
  • CA-074 >=99% (TLC)
  • CA-074（L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide）
  • CA-074（OH）
  • (S)-1-((2S,3S)-3-Methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylic acid
  • CA 074 TFA
  • 134448-10-5
  • C18H29N3O6
  • Inhibitors
  • Cathepsins and Granzymes
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • BioChemical
  • peptides
  • Pepetides
  • Inhibitor