2-Chloro-4-hydroxybenzaldehyde
- Product Name
- 2-Chloro-4-hydroxybenzaldehyde
- CAS No.
- 56962-11-9
- Chemical Name
- 2-Chloro-4-hydroxybenzaldehyde
- Synonyms
- TIMTEC-BB SBB004014;4-Bromo-4-fluoroacetophenone;Benzaldehyde, 2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzaldehyde, 97%,;2-CHLORO-4-HYDROXYBENZALDEHYDE 99% &;2-Chloro-4-hydroxybenzaldehyde ISO 9001：2015 REACH;(1R)-1-(3-bromoisoquinolin-7-yl)-2-phenylethan-1-amine
- CBNumber
- CB7401017
- Molecular Formula
- C7H5ClO2
- Formula Weight
- 156.57
- MOL File
- 56962-11-9.mol
2-Chloro-4-hydroxybenzaldehyde Property
- Melting point:
- 145-147 °C (lit.)
- Boiling point:
- 272.5±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in organic solvents.
- pka
- 6.81±0.18(Predicted)
- form
- solid
- Appearance
- Off-white to light yellow Solid
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C7H5ClO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
- InChIKey
- ZMOMCILMBYEGLD-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(O)C=C1Cl
- CAS DataBase Reference
- 56962-11-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzaldehyde, 2-chloro-4-hydroxy-(56962-11-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 346063
- Product name
- 2-Chloro-4-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 500mg
- Price
- $44.9
- Updated
- 2023/06/20
- Product number
- C3873
- Product name
- 2-Chloro-4-hydroxybenzaldehyde
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $94
- Updated
- 2025/07/31
- Product number
- C3873
- Product name
- 2-Chloro-4-hydroxybenzaldehyde
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $282
- Updated
- 2025/07/31
- Product number
- C367140
- Product name
- 2-Chloro-4-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- J50464
- Product name
- 2-Chloro-4-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
2-Chloro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production
Uses
2-Chloro-4-hydroxybenzaldehyde, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Uses
2-Chloro-4-hydroxybenzaldehyde may be used in chemical synthesis.
General Description
N-Thioamide thiosemicarbazone derivatives of 2-chloro-4-hydroxy-benzaldehyde have been prepared. pK values for acid dissociation of 2-chloro-4-hydroxybenzaldehyde has been evaluated.
Synthesis
108-43-0
67-66-3
56962-11-9
The general procedure for the synthesis of 2-chloro-4-hydroxybenzaldehyde from 3-chlorophenol (CAS 108-43-0) (49.2 g, 0.380 mol) and trichloromethane was as follows: first, 3-chlorophenol, calcium hydroxide (122.0 g) and sodium carbonate (139.4 g) were suspended in water (872 mL). Subsequently, trichloromethane (90.6 g, 0.760 mol) was slowly added over 80 min and the reaction mixture was refluxed for 3 h under vigorous stirring. After completion of the reaction, the mixture was cooled in an ice bath. Next, concentrated hydrochloric acid (385 mL) and trichloromethane (300 mL) were added for extraction and the aqueous layer was discarded. The organic layer was dried with anhydrous sodium sulfate (50 g) followed by evaporation of the solvent under vacuum. The residue was purified by silica gel column chromatography (silica gel 63-100 μm, 600 g, eluents sequentially carbon tetrachloride, chloroform, chloroform/ethyl acetate 93:7). Fractions containing the target product were collected, combined, and the solvents were evaporated and co-evaporated with dioxane to yield 2-chloro-4-hydroxybenzaldehyde (9.77 g, 0.062 mol, 16% yield) as a white powder.1H NMR (DMSO-d6) data were as follows: δ 11.06 (s, 1H, aldehydic hydrogens); 10.14 (s, 1H, hydroxyhydrogens); 7.75 ( d, 1H, J = 8.5 Hz, arylhydrogen); 6.92 (d, 1H, J = 2 Hz, arylhydrogen); 6.85 (dd, 1H, J1 = 8.5 Hz, J2 = 2 Hz, arylhydrogen).
References
[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 98
[2] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 45; 47; 48
[3] Patent: EP2289883, 2011, A1. Location in patent: Page/Page column 19
[4] Journal of Chemical & Engineering Data, 1983, vol. 28, # 1, p. 139 - 141
[5] Journal of Organic Chemistry, 1964, vol. 29, p. 2693 - 2698
2-Chloro-4-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-hydroxybenzaldehyde manufacturers
- Product
- 2-Chloro-4-hydroxybenzaldehyde 56962-11-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
- Product
- 2-Chloro-4-hydroxybenzaldehyde 56962-11-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Chloro-4-hydroxybenzaldehyde 56962-11-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09