5-AMINO-1-ETHYLPYRAZOLE
- Product Name
- 5-AMINO-1-ETHYLPYRAZOLE
- CAS No.
- 3528-58-3
- Chemical Name
- 5-AMINO-1-ETHYLPYRAZOLE
- Synonyms
- AKOS B024267;ART-CHEM-BB B024267;TIMTEC-BB SBB005554;5-Amino-1-ethylpyrazol;1-ethy-pyrazol-5-aMine;2-ethyl-3-pyrazolamine;2-ethylpyrazol-3-amine;2-Amino-1-ethylpyrazole;5-AMINO-1-ETHYLPYRAZOLE;2-Ethyl-3-aMinopyrazole
- CBNumber
- CB7401714
- Molecular Formula
- C5H9N3
- Formula Weight
- 111.15
- MOL File
- 3528-58-3.mol
5-AMINO-1-ETHYLPYRAZOLE Property
- Melting point:
- 52-57 °C (lit.)
- Boiling point:
- 92-94 °C/0.01 mmHg (lit.)
- Density
- 1.0671 (rough estimate)
- refractive index
- 1.5340 (estimate)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 4.18±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 3528-58-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 295760
- Product name
- 5-Amino-1-ethylpyrazole
- Purity
- 99%
- Packaging
- 1g
- Price
- $83
- Updated
- 2023/06/20
- Product number
- 295760
- Product name
- 5-Amino-1-ethylpyrazole
- Purity
- 99%
- Packaging
- 5g
- Price
- $253
- Updated
- 2022/05/15
- Product number
- A3482
- Product name
- 1-Ethyl-1H-pyrazol-5-amine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $89
- Updated
- 2025/07/31
- Product number
- A3482
- Product name
- 1-Ethyl-1H-pyrazol-5-amine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $267
- Updated
- 2025/07/31
- Product number
- B124855
- Product name
- 1-Ethyl-1H-pyrazol-5-amine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
5-AMINO-1-ETHYLPYRAZOLE Chemical Properties,Usage,Production
Uses
5-Amino-1-ethylpyrazole is a heterocyclic building block, has been used in the preparation of 1-protected-1H-pyrazolo[3,4-b]pyridines.
Synthesis
75-07-0
107-13-1
3528-58-3
1. Hydrazine hydrate (98.7 g, 1.97 mol) was slowly added dropwise to a solution of 2-acrylonitrile (100 g, 1.88 mol) in tetrahydrofuran (350 ml) at 0-5 °C. 2. The reaction mixture was stirred at room temperature for 3 h. 3. Acetaldehyde (86.9 g, 1.9 mol) was slowly added dropwise to the above mixture, and stirring was continued for 3 h at room temperature. 4. The solvent was removed by distillation under reduced pressure to give a yellow oil. 5. The oil was dissolved in n-butanol (100 ml), followed by addition of a solution of n-butanol (250 ml) containing potassium tert-butanolate (221 g, 1.9 mol). 6. The reaction mixture was gradually heated from room temperature to 120 °C and maintained at this temperature for 3 h. 7. After completion of the reaction, the reaction was cooled to room temperature, and diluted with water (500 ml). 8. ) for dilution. 8. The reaction mixture was extracted with ethyl acetate (3 x 500 ml). 9. The organic layers were combined and dried over anhydrous sodium sulfate, followed by concentration in vacuo. 10. Purification was carried out by column chromatography using silica gel saturated with triethylamine (100-200 mesh), with 20% ethyl acetate in hexane as eluent. 11. The target fractions were collected to afford 1-ethyl-1H-pyrazol-5-amine, Yield: 66.0 g (1.0 g). 12. , Yield: 66.0 g (15% yield), mass spectrum (m/z): (M+H)+ 111.98.
References
[1] Patent: WO2010/46791, 2010, A1. Location in patent: Page/Page column 30-31
5-AMINO-1-ETHYLPYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-AMINO-1-ETHYLPYRAZOLE manufacturers
- Product
- 5-Amino-1-ethylpyrazol 3528-58-3
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- 5-AMINO-1-ETHYLPYRAZOLE 3528-58-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25