NSC 95397
- Product Name
- NSC 95397
- CAS No.
- 93718-83-3
- Chemical Name
- NSC 95397
- Synonyms
- NSC 95397;Cdc25 Inhibitor IV, NSC 95397;2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE;2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE;2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE;1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-;Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem;Apoptosis,NSC-95397,Inhibitor,NSC 95397,inhibit,NSC95397,Phosphatase
- CBNumber
- CB7402539
- Molecular Formula
- C14H14O4S2
- Formula Weight
- 310.39
- MOL File
- 93718-83-3.mol
NSC 95397 Property
- storage temp.
- -20°C
- solubility
- DMSO: 16 mg/mL
- form
- Orange solid
- color
- orange, solid
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N1786
- Product name
- NSC 95397
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 217694
- Product name
- Cdc25 Inhibitor IV, NSC 95397
- Packaging
- 10mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 21431
- Product name
- NSC 95397
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21431
- Product name
- NSC 95397
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 21431
- Product name
- NSC 95397
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
NSC 95397 Chemical Properties,Usage,Production
Description
NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki? = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4
Uses
NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor.
Definition
ChEBI: 2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione is a member of 1,4-naphthoquinones.
Biological Activity
Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G 2 /M phase transition in vitro .
Biochem/physiol Actions
Irreversible Cdc25 dual specificity phosphatase inhibitor.
storage
Desiccate at -20°C
References
1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720 2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016 3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663 4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597
NSC 95397 Preparation Products And Raw materials
Raw materials
Preparation Products
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