2,4-Dihydroxy-3-nitropyridine
Uses- Product Name
- 2,4-Dihydroxy-3-nitropyridine
- CAS No.
- 89282-12-2
- Chemical Name
- 2,4-Dihydroxy-3-nitropyridine
- Synonyms
- 3-NITRO-2,4-PYRIDINEDIOL;Dihydroxy-3-nitropyridine;4-Dihydroxy-3-nitropyridine;2,4-Dihyroxy-3-nitropyridine;2,4-Hydroxy-3-nitropyridine.;4-Hydroxy-3-nitro-2-pyridone;2,4-Diydroxy-3-nitropyridine;2,4-DIHYDROXY-3-NITROPYRIDINE;4,6-DIHYDROXY-5-NITRO PYRIDINE;2,4-Dihydroxy-3-nitropyridine-1
- CBNumber
- CB7405853
- Molecular Formula
- C5H4N2O4
- Formula Weight
- 156.1
- MOL File
- 89282-12-2.mol
2,4-Dihydroxy-3-nitropyridine Property
- Melting point:
- 265°C (dec.)
- Boiling point:
- 305.6±42.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 4.50±1.00(Predicted)
- color
- Light yellow to Yellow to Green
- BRN
- 149558
- InChI
- InChI=1S/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9)
- InChIKey
- BKYGVGWYPFVKTK-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=CC(O)=C1[N+]([O-])=O
- CAS DataBase Reference
- 89282-12-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37
- RIDADR
- 3335
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- R436798
- Product name
- 2,4-DIHYDROXY-3-NITROPYRIDINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- R436798
- Product name
- 2,4-DIHYDROXY-3-NITROPYRIDINE
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- D4002
- Product name
- 2,4-Dihydroxy-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- D4002
- Product name
- 2,4-Dihydroxy-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $133
- Updated
- 2025/07/31
- Product number
- B506300
- Product name
- 3-Nitropyridine-2,4-diol
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
2,4-Dihydroxy-3-nitropyridine Chemical Properties,Usage,Production
Uses
2,4-Dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemical, and organic synthesis intermediate. During synthetic transformation, the hydroxyl groups in the structure can be easily converted into halogen atoms due to the influence of the pyridine ring and nitro group. It should be noted that by changing the reaction conditions, one of the two hydroxyl groups can be selectively halogenated, or both can be converted simultaneously. Furthermore, under acidic conditions, a bromine atom can be introduced at the 5-position of the pyridine using liquid bromine.
Chemical Properties
Yellow powder
Reactions
2,4-Dihydroxy-3-nitropyridine could be quickly transformed into 5-bromo-2,4-dihydroxy-3-nitropyridine by the action of a solution of bromine. 3.5 g of 2,4-Dihydroxy-3-nitropyridine were heated with a mixture of 1.15 ml of bromine and 30 ml of acetic acid at 70℃ for 15 minutes. When the reaction mixture was cooled with ice, 3.7 g of 5-bromo-2,4-dihydroxy-3-nitropyridine separated out[1]. Yield: 70 %
Synthesis
626-03-9
89282-12-2
Step 59a. Synthesis of 2,4-dihydroxy-3-nitropyridine (compound 0108): fuming nitric acid (90 mL) was slowly added to a stirring solution of 2,4-dihydroxypyridine (0601) (100 g, 0.9 mol) dissolved in ethyl acetate (300 mL) at 0 °C. After 45 minutes of reaction, the reaction solution was carefully poured into crushed ice and the mixture was cooled in a refrigerator. The resulting precipitate was collected by filtration, washed with cold water and dried to give 4-hydroxy-3-nitropyridin-2(1H)-one (0108) (135 g, 96% yield) as a light yellow solid.LCMS: 157 [M + 1]+; 1H NMR (DMSO-d6) δ 6.05 (d, 1H, J = 7.2 Hz), 7.47 (d, 1H, J = 7.2 Hz), 11.91 (s, 1H), 12.47 (s, 1H).
References
[1] Kolder, C. R. , and H. J. D. Hertog . Migration of halogen atoms in halogeno-derivatives of 2,4-dihydroxypyridine (II). Recueil des Travaux Chimiques des Pays-Bas 72.10(2010):853-858.
2,4-Dihydroxy-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dihydroxy-3-nitropyridine Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
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- Country
- Japan
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View Lastest Price from 2,4-Dihydroxy-3-nitropyridine manufacturers
- Product
- 2,4-Dihydroxy-3-nitropyridine 89282-12-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 2,4-Dihydroxy-3-nitropyridine 89282-12-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2,4-Dihydroxy-3-nitropyridine 89282-12-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22