KADETHRIN Property

Melting point:

31℃

Boiling point:

526.2±50.0 °C(Predicted)

Density 

1.278±0.06 g/cm3(Predicted)

vapor pressure 

5×10^-6Pa (20 °C)

Flash point:

100 °C

storage temp. 

0-6°C

Water Solubility 

1mg l^-1（20°C）

EPA Substance Registry System

Kadethrin (58769-20-3)

Safety

Hazard Codes 

Xn,N

Risk Statements 

20/21/22-50/53

Safety Statements 

13-60-61

RIDADR 

UN 3082 9/PG 3

RTECS 

GZ1266550

Hazardous Substances Data

58769-20-3(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

KADETHRIN Chemical Properties,Usage,Production

Uses

Kadethrin is used to control household pests, particularly houseflies, mosquitoes and cockroaches. It is normally used in combination with other pyrethroid insecticides and synergists.

Metabolic pathway

Kadethrin is used almost wholly indoors and therefore little has been published on its environmental fate. Information on its photodegradation and metabolism in rats has been reported.

Degradation

Kadethrin is unstable to heat and it is rapidly decomposed by light. It is hydrolysed in aqueous alkaline solution to (E)-(1R)-cis-2,2-dimethyl-3- (2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylic acid (2), 5-benzyl- 3-furylmethanol (3) and its thiolactone ring-opened derivative (5) (Scheme 1).
Products of photodecomposition have been reported by Ohsawa and Casida (1979). Photo-hydrolysis of kadethrin occurs on sunlight irradiation affording 2 and 5 and 5-benzyl-3-furancarboxylic acid (4), presumably via the alcohol (3). cis-trans Isomerisation of the cyclopropane ring and E-Z interconversion about the double bond was also noted. Thus, from the lRcisE isomer (kadethrin), all of the possible isomers were found to varying degrees (ie. 1RScis-trans-E-Z mixtures).
Photo-hydrolysis products (e.g. 2 and 5) were also found aS isomers. The facility of the isomerisation process was considered to be due to resonance stabilisation of a triplet diradical, one form of which (6) is shown in Scheme 1. Kadethrin also yielded a lactone (7) derived from the cyclopropane ring. Photo-oxidation of the alcohol moiety analogous to that reported for resmethrin was also found. The hydroxylactone (8) and the benzyloxylactone (9) were reported (but the hydroxycyclopetenolone [resmethrin, 61) was absent.