ChemicalBook > CAS DataBase List > ISOGUVACINE HYDROCHLORIDE

ISOGUVACINE HYDROCHLORIDE

Product Name
ISOGUVACINE HYDROCHLORIDE
CAS No.
64603-90-3
Chemical Name
ISOGUVACINE HYDROCHLORIDE
Synonyms
C13694;isoguvacine;ISOGUVACINE HCL;Isoguvacine hydrochl;ISOGUVACINE HYDROCHLORIDE;1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid;ISOGUVACINE HYDROCHLORIDE ISO 9001:2015 REACH;4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-;1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine);1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
CBNumber
CB7406481
Molecular Formula
C6H9NO2
Formula Weight
127.14
MOL File
64603-90-3.mol
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ISOGUVACINE HYDROCHLORIDE Property

Melting point:
220 °C
Boiling point:
280.8±35.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
RTECS 
US5908286
storage temp. 
Store at RT
solubility 
H2O: refrigerate if not used immediately.soluble
form 
solid
pka
pK1:9.07 (25°C)
color 
white
Water Solubility 
Soluble in water
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J63243
Product name
Isoguvacine hydrochloride, 99%
Packaging
100mg
Price
$350
Updated
2021/12/16
Tocris
Product number
0235
Product name
Isoguvacine hydrochloride
Purity
≥99%(HPLC)
Packaging
100
Price
$223
Updated
2021/12/16
Usbiological
Product number
255530
Product name
Isoguvacine hydrochloride
Packaging
100mg
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008224
Product name
ISOGUVACINE
Purity
95.00%
Packaging
500MG
Price
$718.41
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008224
Product name
ISOGUVACINE
Purity
95.00%
Packaging
1G
Price
$1021.65
Updated
2021/12/16
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ISOGUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.

Chemical Properties

bp 195-197°C

Uses

A GABAA receptor agonist. Anticonvulsant; antiepileptic.

Definition

ChEBI: Isoguvacine is a tetrahydropyridine.

Biological Activity

Specific GABA A receptor agonist.

References

Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)

ISOGUVACINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOGUVACINE HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12036
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
1927
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Shanghai WangFa Chemical Technology Co., Ltd.
Tel
13918479294
Fax
-
Email
xiebenfa@163.com
Country
China
ProdList
3432
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2119
Advantage
58

64603-90-3, ISOGUVACINE HYDROCHLORIDERelated Search:


  • isoguvacine
  • C13694
  • 1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid
  • 4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-
  • ISOGUVACINE HCL
  • ISOGUVACINE HYDROCHLORIDE
  • 1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBOXYLIC ACIDHYDROCHLORIDE
  • 1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
  • ISOGUVACINE HYDROCHLORIDE ISO 9001:2015 REACH
  • Isoguvacine hydrochl
  • 1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine)
  • 64603-90-3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ion Channels
  • Ligand-Gated Ion Channels
  • GABA and Glycine Receptor Modulators
  • GABA/Glycine receptor