ChemicalBook > CAS DataBase List > ISOGUVACINE HYDROCHLORIDE

ISOGUVACINE HYDROCHLORIDE

Product Name
ISOGUVACINE HYDROCHLORIDE
CAS No.
64603-90-3
Chemical Name
ISOGUVACINE HYDROCHLORIDE
Synonyms
C13694;isoguvacine;ISOGUVACINE HCL;Isoguvacine hydrochl;ISOGUVACINE HYDROCHLORIDE;1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid;ISOGUVACINE HYDROCHLORIDE ISO 9001：2015 REACH;4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-;1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine);1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
CBNumber
CB7406481
Molecular Formula
C6H9NO2
Formula Weight
127.14
MOL File
64603-90-3.mol
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ISOGUVACINE HYDROCHLORIDE Property

Melting point:
220 °C
Boiling point:
280.8±35.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
RTECS 
US5908286
storage temp. 
Store at RT
solubility 
H2O: refrigerate if not used immediately.soluble
form 
solid
pka
pK1:9.07 (25°C)
color 
white
Water Solubility 
Soluble in water
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J63243
Product name
Isoguvacine hydrochloride, 99%
Packaging
100mg
Price
$350
Updated
2021/12/16
Tocris
Product number
0235
Product name
Isoguvacine hydrochloride
Purity
≥99%(HPLC)
Packaging
100
Price
$223
Updated
2021/12/16
Usbiological
Product number
255530
Product name
Isoguvacine hydrochloride
Packaging
100mg
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008224
Product name
ISOGUVACINE
Purity
95.00%
Packaging
500MG
Price
$718.41
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008224
Product name
ISOGUVACINE
Purity
95.00%
Packaging
1G
Price
$1021.65
Updated
2021/12/16
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ISOGUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.

Chemical Properties

bp 195-197°C

Uses

A GABAA receptor agonist. Anticonvulsant; antiepileptic.

Definition

ChEBI: Isoguvacine is a tetrahydropyridine.

Biological Activity

Specific GABA A receptor agonist.

References

Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)

ISOGUVACINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOGUVACINE HYDROCHLORIDE Suppliers

China 28 Germany 2 India 3 Switzerland 1 United Kingdom 2 United States 10 Global 46
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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JW & Y Pharmlab Co., Ltd.
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Amadis Chemical Company Limited
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571-89925085
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Career Henan Chemica Co
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LGC Science (Shanghai) Ltd.
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Shanghai Haohong Scientific Co., Ltd.
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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64603-90-3, ISOGUVACINE HYDROCHLORIDERelated Search:

1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE BOC-1,2,5,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID 5-HYDROXY-6-OXO-1,2,3,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85 ISOGUVACINE HYDROCHLORIDE FMOC-1,2,5,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID AKOS 247 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylic acid Ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate

  • isoguvacine
  • C13694
  • 1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid
  • 4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-
  • ISOGUVACINE HCL
  • ISOGUVACINE HYDROCHLORIDE
  • 1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBOXYLIC ACIDHYDROCHLORIDE
  • 1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
  • ISOGUVACINE HYDROCHLORIDE ISO 9001：2015 REACH
  • Isoguvacine hydrochl
  • 1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine)
  • 64603-90-3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ion Channels
  • Ligand-Gated Ion Channels
  • GABA and Glycine Receptor Modulators
  • GABA/Glycine receptor