ChemicalBook > CAS DataBase List > Sulbutiamine

Sulbutiamine

Product Name
Sulbutiamine
CAS No.
3286-46-2
Chemical Name
Sulbutiamine
Synonyms
SULBUTIAMINE;formylamino]-3-penten-1-ol] bis(2-methylpropionate);arcalion;Vitaberin;Solbutiamine;BISIBUTIAMINE;Sulbutiaminum;Bisibuthiamine;Shubu Thiamine;Sulbutiamine>
CBNumber
CB7407024
Molecular Formula
C32H46N8O6S2
Formula Weight
702.89
MOL File
3286-46-2.mol
More
Less

Sulbutiamine Property

Melting point:
140.5-141.5 °C
Boiling point:
892.5±65.0 °C(Predicted)
Density 
1.1323 (rough estimate)
refractive index 
1.7400 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
5.82±0.10(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,9297
Stability:
Hygroscopic
InChIKey
CKHJPWQVLKHBIH-UHFFFAOYSA-N
SMILES
C(CCOC(=O)C(C)C)(SSC(CCOC(=O)C(C)C)=C(C)N(C=O)CC1=CN=C(C)N=C1N)=C(C)N(C=O)CC1=CN=C(C)N=C1N
CAS DataBase Reference
3286-46-2(CAS DataBase Reference)
More
Less

Safety

RTECS 
LQ2721000
HS Code 
2933.59.9500
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
S0964
Product name
Sulbutiamine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$83
Updated
2024/03/01
TCI Chemical
Product number
S0964
Product name
Sulbutiamine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$285
Updated
2024/03/01
TRC
Product number
S689250
Product name
Sulbutiamine
Packaging
50g
Price
$215
Updated
2021/12/16
Chem-Impex
Product number
38266
Product name
Sulbutiamine,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
5G
Price
$81.54
Updated
2021/12/16
Chem-Impex
Product number
38266
Product name
Sulbutiamine,98%(HPLC)
Purity
98%(HPLC)
Packaging
25G
Price
$296.8
Updated
2021/12/16
More
Less

Sulbutiamine Chemical Properties,Usage,Production

Description

Sulbutiamine is a vitamin B1 derivative developed by the French Servier Pharmaceuticals. The product is described in Special Drug Patent 5921M as a formulation with vitamin B1 activity, which is able to increase the blood level of vitamin B1 and has a therapeutic effect on all vitamin B1 deficiencies.

Chemical Properties

Sulbutiamine is a white solid. It is a synthetic compound, which consists of two thiamine molecules bound together by a sulfur group. Due to the fact that sulbutiamine is a dimer of two thiamine molecules, it is a lipophilic drug that crosses the blood-brain barrier more quickly than thiamine(Farid and Abdelwahab,2016).Thus, sulbutiamine has neurotropic action and can increases the levels of thiamine and thiamine phosphate esters in the brain (Sevim et al.,2017).

Uses

Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.

benefits

Sulbutiamine belongs to the class of medicines called an artificial vitamin. It contains Sulbutiamine, which is similar to vitamin B1 (thiamine). It is used for the symptomatic treatment of asthenia. SULBUTIAMINE works by increasing the thiamine levels in the brain. It is thought to have mild stimulant effects. Thereby it improves memory and reduces feelings of weakness. It may also be used in combination with other medicines to improve everyday activities in Alzheimer's disease.

General Description

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form a dimer. It is highly lipophilic, allowing it to cross the blood-brain barrier more easily than other thiamine derivatives. Although its clinical efficacy is not yet defined, sulbutiamine is used to treat asthenia. While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical transmissions. The chronic administration of the drug has demonstrated to improve long term memory formation in mice.

Side effects

Sulbutiamine is very well tolerated at normal doses, with the only reported side effects at normal doses being mild headaches, nausea, and a decline in mood. At very high doses, mild agitation and skin irritation is sometimes reported. For this reason it is not recommended to exceed a dose of 4 capsules per day. Please consult with your physician before taking Sulbutiamine.?

Safety

Sulbutiamine is a very safe drug, but its effects vary widely depending on the individual. Some people consider it too stimulating yet others find its effects sedative. Despite possible stimulation sulbutiamine is not thought to cause insomnia. Depression and anxiety have been reported occasionally. Large doses can cause headaches. No drug interactions or contraindications are known, but it has been suggested that people with bipolar disorder should not use sulbutiamine.

Sulbutiamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Sulbutiamine Suppliers

TCI EUROPE N.V.
Tel
--
Fax
--
Email
sales@tcieurope.be
Country
Belgium
ProdList
2200
Advantage
66
More
Less

View Lastest Price from Sulbutiamine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Sulbutiamine 3286-46-2
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Bisibutiamine 3286-46-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101%
Supply Ability
100kg
Release date
2021-06-02
Wuhan Haorong Biotechnology Co.,Ltd
Product
Sulbutiamine 3286-46-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000
Release date
2023-08-11

3286-46-2, SulbutiamineRelated Search:


  • arcalion
  • BISIBUTIAMINE
  • SULBUTIAMINE
  • Bisibuthiamine
  • SULBUTIAMINE(ARCALION,BISIBUTIAMINE)
  • O,O-Diisobutyrate
  • 3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate)
  • Bis(2-methylpropionic acid)[dithiobis[3-[1-[[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino]ethylidene]-3,1-propanediyl]] ester
  • O-Isobutyrylthiamine disulfide
  • Thiamine disulfide O,O-diisobutyrate
  • 2-Methylpropanoic Acid 1,1'-[Dithiobis[3-[1-[[(4-aMino-2-Methyl-5-pyriMidinyl) Methyl]forMylaMino]ethylidene]-3,1-propanediyl]] Ester
  • Vitaberin
  • 1kg 5kg 10kg
  • SulbutiaMine-d14
  • diisobutyrate(ester)
  • o,o’-diisobutyrylthiaminedisulfide
  • o-isobutyroylthiaminedisulfide
  • [4-[(4-amino-2-methylpyrimidin-5-yl)methylformylamino]-3-[2-[(4-amino-2-methylpyrimidin-5-yl)methylformylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanylpent-3-enyl] 2-methylpropanoate
  • 2-methylpropanoic acid [5-[[(4-amino-2-methyl-5-pyrimidinyl)-oxomethyl]-methylamino]-3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)-oxomethyl]-methylamino]ethylidene]-6,6-dimercapto-4-[2-(2-methyl-1-oxopropo
  • Sulbutiamine&gt
  • Sulbutiaminum
  • Propanoic acid, 2-methyl-, 1,1'-[dithiobis[3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl]] ester
  • formylamino]-3-penten-1-ol] bis(2-methylpropionate)
  • Propanoic acid, 2-methyl-,dithiobis[3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl] ester
  • SulbutiamineQ: What is Sulbutiamine Q: What is the CAS Number of Sulbutiamine Q: What is the storage condition of Sulbutiamine Q: What are the applications of Sulbutiamine
  • Disulfanediylbis(4-(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido)pent-3-ene-3,1-diyl) bis(2-methylpropanoate)
  • Solbutiamine
  • Shubu Thiamine
  • 3286-46-2
  • 799026-31-8
  • C32H46N8O6S2
  • API
  • Vitamins and derivatives
  • 3286-46-2