sn-Glycero-3-phosphocholine
- Product Name
- sn-Glycero-3-phosphocholine
- CAS No.
- 28319-77-9
- Chemical Name
- sn-Glycero-3-phosphocholine
- Synonyms
- Alpha GPC;GPC;CHOLINE ALFOSCERATE;glycerophosphocholine;SN-GLYCERO-3-PHOSPHOCHOLINE;GLYCEROPHOSPHORYLCHOLINE;L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE;Alpha GPC powder;L-α-glycerylphosphorylcholine;L-α-Glycerophosphorylcholine
- CBNumber
- CB5309777
- Molecular Formula
- C8H20NO6P
- Formula Weight
- 257.22
- MOL File
- 28319-77-9.mol
sn-Glycero-3-phosphocholine Property
- Melting point:
- 142.5-143°
- alpha
- D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
- Boiling point:
- 480℃[at 101 325 Pa]
- vapor pressure
- 0Pa at 25℃
- Flash point:
- 11 °C
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly)
- form
- solid
- color
- White to Off-White
- Water Solubility
- 1000g/L at 25℃
- Stability:
- Very Hygroscopic
- InChI
- InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
- InChIKey
- SUHOQUVVVLNYQR-SBYBRXNCNA-N
- SMILES
- P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO |&1:12,r|
- LogP
- -5.15 at 25℃
- CAS DataBase Reference
- 28319-77-9(CAS DataBase Reference)
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 16-36/37-45-24/25
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 2
- RTECS
- KH2775000
- HS Code
- 29239000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G5291
- Product name
- L-α-Glycerophosphorylcholine
- Purity
- from soybean, ≥98%, powder
- Packaging
- 50mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- G5291
- Product name
- L-α-Glycerophosphorylcholine
- Purity
- from soybean, ≥98%, powder
- Packaging
- 100mg
- Price
- $318
- Updated
- 2024/03/01
- Product number
- 20736
- Product name
- sn-glycero-3-Phosphocholine
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 20736
- Product name
- sn-glycero-3-Phosphocholine
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- G5291
- Product name
- L-α-Glycerophosphorylcholine
- Purity
- from soybean, ≥98%, powder
- Packaging
- 10mg
- Price
- $63.8
- Updated
- 2024/03/01
sn-Glycero-3-phosphocholine Chemical Properties,Usage,Production
Description
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
Chemical Properties
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
Originator
Sandoz; Italfarmaco (Italy)
Uses
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
Uses
L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.
Definition
ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
brand name
Delecit
General Description
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Increases inositol phosphate formation.
Synthesis
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).
sn-Glycero-3-phosphocholine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from sn-Glycero-3-phosphocholine manufacturers
- Product
- Choline glycerophosphate 28319-77-9
- Price
- US $1.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99%
- Supply Ability
- 200KG
- Release date
- 2024-07-26
- Product
- Choline glycerophosphate 28319-77-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-03-26
- Product
- Alpha-GPC Choline Glycerophosphate 28319-77-9
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-21