ChemicalBook > CAS DataBase List > CORTICOSTERONE

CORTICOSTERONE

Product Name
CORTICOSTERONE
CAS No.
50-22-6
Chemical Name
CORTICOSTERONE
Synonyms
21-Dihydroxyprogesterone;NSC-9705;compoundb;Compound B;Azlocilline;KENDALL'S 'B';Corticosteron;CORTICOSTERONE;Reichstein's B;17-Deoxycortisol
CBNumber
CB7418589
Molecular Formula
C21H30O4
Formula Weight
346.47
MOL File
50-22-6.mol
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CORTICOSTERONE Property

Melting point:
179-183 °C(lit.)
alpha 
D15 +223° (c = 1.1 in alc)
Boiling point:
401.19°C (rough estimate)
Density 
1.0413 (rough estimate)
refractive index 
1.4430 (estimate)
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated)
form 
White to tan crystalline powder
color 
White to Pale Yellow
optical activity
[α]20/D +223±3°, c = 1% in ethanol
Water Solubility 
240.5mg/L(37 ºC)
Merck 
2538
BRN 
2339601
Stability:
Stable, but light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-22-6(CAS DataBase Reference)
EPA Substance Registry System
Corticosterone (50-22-6)
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Safety

Hazard Codes 
Xi,N,Xn,T,F
Risk Statements 
43-40-39/23/24/25-23/24/25-11
Safety Statements 
36-22-45-36/37-16
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
GM7650000
HS Code 
29372900
Toxicity
An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C-117
Product name
Corticosterone solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$99
Updated
2024/03/01
Sigma-Aldrich
Product number
27840
Product name
Corticosterone
Purity
≥98.5% (HPLC)
Packaging
100mg
Price
$33.1
Updated
2024/03/01
Sigma-Aldrich
Product number
235135
Product name
Corticosterone - CAS 50-22-6 - Calbiochem
Purity
Corticosteroid hormone synthesized in response to stress.
Packaging
1g
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
C174
Product name
Corticosterone: HBC complex
Purity
free flowing powder
Packaging
100MG
Price
$182
Updated
2023/06/20
Cayman Chemical
Product number
16063
Product name
Corticosterone
Purity
≥98%
Packaging
100mg
Price
$32
Updated
2024/03/01
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CORTICOSTERONE Chemical Properties,Usage,Production

Description

Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.

Chemical Properties

white to light yellow powder

Uses

Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.

Uses

Corticosterone: HBC complex has been used:

  • in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
  • to induce acute stress in mice
  • in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription

Uses

Corticosteroid is an activator of MCR.

Definition

ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan s.

General Description

Corticosterone is a corticosteroid and aldosterone precursor produced in the adrenal glands. Serum corticosterone levels are measured by LC-MS/MS for newborn screening and diagnosis of 11-hydroxylase deficiency.

Biological Activity

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Biochem/physiol Actions

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

target

IL Receptor | TNF-α | AChR

storage

Room temperature

Purification Methods

Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]

CORTICOSTERONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CORTICOSTERONE manufacturers

Henan Fengda Chemical Co., Ltd
Product
CORTICOSTERONE 50-22-6
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Corticosterone 50-22-6
Price
US $0.00/g
Min. Order
1KG
Purity
98.0%
Supply Ability
20kg/month
Release date
2021-07-19
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
CORTICOSTERONE 50-22-6
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99%
Supply Ability
50tons
Release date
2023-08-29

50-22-6, CORTICOSTERONERelated Search:

L(-)-Epinephrine Hydrocortisone sodium succinate Hydrocortisone Hydrocortisone acetate Hydrocortisone 21-hemisuccinate 17α-(Butyryloxy)corticosterone Flurandrenolide CORTICOSTERONE CORTICOSTERONE 21-ACETATE,CORTICOSTERONE ACETATE Hydrocortisone sodium phosphate CORTISOL 17-VALERATE 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate (6CI) Inositol HYDROCORTISONE CYPIONATE (200 MG) 18-deoxyaldosterone Corticosterone 21-sulfate potassium salt D-ALDOSTERONE 18,21-DIACETATE

  • 11,12-dihydroxyprogesterone
  • 21-Dihydroxyprogesterone
  • 11BETA,21-DIHYDROXY-PROGESTERONE
  • 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
  • 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE
  • (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
  • KENDALL'S 'B'
  • KENDALL'S COMPOUND B
  • KENDALL'S COMPOUND ''B''
  • KENDALL'S COMPOUND 'B'
  • CORTICOSTERONE
  • DELTA4-PREGNEN-11BETA, 21-DIOL-3, 20-DIONE
  • 11β,21-Dihydroxy-4-pregnene-3,20-dione
  • 4-Pregnene-11β,21-diol-3,20-dione
  • CORTICOSTERONE CRYSTALLINE
  • CORTICOSTERONE VETRANAL, 100 MG
  • (8R,9S,10S,11R,13S,14R,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • CORTICOSTERONE(RG)
  • 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendalls Compound B, Reichsteins Substance H
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17S)-17-glycoloyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
  • Corticosterone,11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
  • 4-Pregnen-11,21-diol-3,20-dione-d8
  • (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • Corticosterone solution
  • corticosterone solution,100ppm
  • Corticosterone - CAS 50-22-6 - Calbiochem
  • 11,21-Dihydroxypregn-4-ene-3,20-dione
  • 11,21-Dihydroxyprogesterone
  • 11-beta,21-Dihydroxypregn-3,20-dione
  • 11-beta,21-dihydroxy-pregn-4-ene-20-dione
  • 11-Hydroxycorticoaldosterone
  • 17-Deoxycortisol
  • 21-dihydroxy-20-dion(11-beta)-pregn-4-ene-11
  • Compound B
  • compoundb
  • Corticosteron
  • NSC-9705
  • Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-
  • Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-
  • Reichstein's B
  • REICHSTEIN'S SUBSTANCE H
  • REICHSTEIN'S SUBSTANCE ''H''
  • REICHSTEIN'S SUBSTANCE 'H'
  • 4-PREGNEN-11B,21-DIOL-3,20-DIONE
  • 4-PREGNEN-11-BETA, 21-DIOL-3,20-DIONE
  • 4-PREGNENE-11BETA,21-DIOL-3,20-DIONE
  • 11BETA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
  • Corticosterone&gt
  • Corticosterone Corticosterone
  • CORTICOSTERONE USP/EP/BP
  • Pregn-4-ene-3,20-dione,11,21-dihydroxy-, (11b)-
  • 11β,21-Dihydroxyprogesterone
  • Azlocilline
  • Corticisterone Corticosteroid Raw Powder
  • Corticosterone- -d4