ChemicalBook > CAS DataBase List > 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether

Product Name
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
CAS No.
72-33-3
Chemical Name
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
Synonyms
33355;EE3ME;d-MVE;sc4725;RS 1044;Devocin;Norquen;Ovastol;SC 4725;MESTRANOL
CBNumber
CB7426942
Molecular Formula
C21H26O2
Formula Weight
310.43
MOL File
72-33-3.mol
More
Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Property

Melting point:
153-155 °C(lit.)
Boiling point:
390.58°C (rough estimate)
alpha 
+2~+8°(D/20℃)(c=1, 1,4-dioxane)
Density 
1.0865 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form 
Solid
pka
13.10±0.40(Predicted)
color 
White to off-white
optical activity
[α]15/D +3°, c = 2 in dioxane
Merck 
5917
BRN 
2625905
CAS DataBase Reference
72-33-3(CAS DataBase Reference)
NIST Chemistry Reference
Mestranol(72-33-3)
EPA Substance Registry System
Mestranol (72-33-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-40-48-68
Safety Statements 
22-26-36/37/39-45-36/37
WGK Germany 
3
RTECS 
RC8960000
HS Code 
29372900
Hazardous Substances Data
72-33-3(Hazardous Substances Data)
Toxicity
LD50 oral in rat: > 10gm/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
855871
Product name
Mestranol
Purity
99%
Packaging
500mg
Price
$79
Updated
2024/03/01
Sigma-Aldrich
Product number
1394008
Product name
Mestranol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$164.8
Updated
2024/03/01
Cayman Chemical
Product number
23822
Product name
Mestranol
Purity
≥98%
Packaging
10mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
23822
Product name
Mestranol
Purity
≥98%
Packaging
50mg
Price
$98
Updated
2024/03/01
Sigma-Aldrich
Product number
M0600000
Product name
Mestranol
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
m0600000
Price
$60
Updated
2024/03/01
More
Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Enovid ,Searle ,US ,1957

Uses

Pharmacological estrogen molecule

Uses

Mestranol is an orally active estrogenic steroid. It was the estrogen used in many of the first oral contraceptives

Uses

antiemetic

Definition

ChEBI: A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.

Manufacturing Process

A stirred solution of 120 parts of 3-methoxy-δ1,3,5-estratrien-17-one in 2,600 parts of anhydrous toluene and 4,300 parts of anhydrous ether is saturated with a slow stream of acetylene. In the course of 30 minutes there is added a solution of 120 parts of potassium tert-amylate in 2,800 parts of anhydrous tert-pentanol. The passage of acetylene and stirring are continued for an additional 5 hours after which the reaction mixture is washed 5 times with 3,000-part portions of saturated ammonium chloride solution and then with water. It is then dried over anhydrous sodium sulfate and concentrated to dryness under vacuum. The residue is recrystallized from methanol. The 3- methoxy-17-ethynyl-δ1,3,5 estratrien-17-ol thus obtained melts at about 143° to 146°C. A further recrystallization from acetone yields crystals melting at about 150° to 151°C.

Therapeutic Function

Estrogen

Safety Profile

Confirmed carcinogen with experimental. neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by subcutaneous route. Human reproductive effects by ingestion: changes in ovaries and fallopian tubes, ferthty effects. Experimental reproductive effects. Mutation data reported. An FDA proprietary drug. A steroid used in oral contraceptives. When heated to decomposition it emits acrid smoke and irritating fumes.

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Suppliers

HUBEI PROVINCIAL BAFENG PHARMACEUTICALS & CHEMICALS SHARE CO.,LTD.
Tel
0718-5265266 15327050690
Fax
86-27-83940390
Email
ygh198@126.com
Country
China
ProdList
22
Advantage
67
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
More
Less

View Lastest Price from 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether manufacturers

Wuhan Han Sheng New Material Technology Co.,Ltd
Product
mestranol 72-33-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50TONS
Release date
2023-04-19
Guangzhou Biocar Biotechnology Co.,Ltd.
Product
mestranol 72-33-3
Price
US $1.00/g
Min. Order
10g
Purity
99.5%
Supply Ability
1000kg
Release date
2022-01-12
Shanghai Biolang Biotechnology Co., Ltd.
Product
mestranol 72-33-3
Price
US $9.90-7.70/g
Min. Order
10g
Purity
99.99%HPLC.USP42
Supply Ability
1000kgs
Release date
2022-02-22

72-33-3, 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl etherRelated Search:


  • Ethynylestradiol 3-methyl ether,97%
  • 17alpha-19-Norpregna-1,3,5(10)-trien-20-yn
  • MESTRANOL
  • 19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-
  • 19-nor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy-
  • 19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17alpha)-
  • 3,17-beta-Dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene-3-methyl ether
  • 3,17-beta-dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene-3-methylether
  • 33355
  • 3-methoxy-17a-ethynyl-1,3,5(10)-estratriene-17b-ol
  • 3-methoxy-17-alpha-19-norpregna-1,3,5(10)-trien-20-yn-17-ol
  • 3-methoxy-17-alpha-ethinylestradiol
  • 3-Methoxy-17alpha-ethinylestradiol
  • 3-methoxy-17-alpha-ethinyloestradiol
  • 3-Methoxy-17alpha-ethinyloestradiol
  • 3-methoxy-19-nor-17α-pregna-1,2,5(10)-triene-20-yn-17-ol
  • 3-Methoxyethynylestradiol
  • 3-methoxyethynyloestradiol
  • 3-Methylethynylestradiol
  • 3-methylethynyloestradiol
  • 3-O-Methylethynylestradiol
  • 5(10)-trien-17-beta-ol,17-alpha-ethynyl-3-methoxy-estra-3
  • 5(10)-trien-20-yn-17-ol,3-methoxy-17-alpha-19-norpregna-3
  • 8027 C. B.
  • component of Norinyl
  • component of Norquen
  • component of Ortho-Novum
  • component of Ovulen
  • Compound 33355
  • compound33355
  • delta-MVE
  • sc4725
  • ETHYNYLESTRADIOL 3-METHYL ETHER
  • ETHINYLESTRADIOL METHYL ETHER
  • 3-METHOXY-17ALPHA-ETHYNYLESTRADIOL
  • (8R,9S,13S,14S,17R)-17-ETHYNYL-3-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-OL
  • 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
  • 17A-ETHYNYLESTRADIOL 3-METHYLTHER
  • (17A)-3-METHOXY-19-NORPREGMA-1,3,5(10)-TRIEN-20-YN-17-OL
  • 17-ALPHA-ETHINYL-OESTRADIOL-3-METHYL ETHER
  • 17ALPHA-ETHYNYL-1,3,5(10)-ESTRATRIENE-3,17BETA-DIOL 3-METHYL ETHER
  • 17ALPHA-ETHYNYLESTRADIOL 3-METHYL ETHER
  • 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL 3-METHYL ETHER
  • 3-Methoxy-19-nor-17α-pregna-1,3,5[10]-trien-20-yn-17-ol
  • 17a-Ethynyl-3-methoxy-17b-hydroxy-1,3,5(10)-estratriene
  • 3-Methoxy-17a-ethynylestradiol
  • (17a)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol
  • Menophase
  • 17α-ethynyl-1,3,5(10)-estratriene-3,17β-diol 3-methyl ether
  • 17a-Ethinylestradiol 3-methyl ether
  • 17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol
  • 17a-Ethynyl-3-methoxy-17b-hydroxy-D1,3,5(10)-estratriene
  • 17a-Ethynylestradiol methyl ether
  • 17-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-o1
  • 17-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17b-ol
  • 19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy- (6CI, 8CI)
  • MESTRANOL, VETRANAL 100MG
  • MESTRANOL 98+%