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ChemicalBook > CAS DataBase List > 3-(TRIFLUOROMETHYL)PHENACYL BROMIDE

3-(TRIFLUOROMETHYL)PHENACYL BROMIDE

Uses
Product Name
3-(TRIFLUOROMETHYL)PHENACYL BROMIDE
CAS No.
2003-10-3
Chemical Name
3-(TRIFLUOROMETHYL)PHENACYL BROMIDE
Synonyms
BUTTPARK 35\01-54;3-(TRIFLUOROMETHYL)PHENACYL BROMIDE;2-Bromo-3'-(trifluoromethyl)acetophenone;3-(Trifluoromethyl)phenacyl bromide (267);2-Bromo-3'-(trifluoromethyl)acetophenone,98%;2-BROMO-1-(3-TRIFLUOROMETHYL-PHENYL)-ETHANONE;2-BROMO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1-ETHANONE;Ethanone, 2-bromo-1-[3-(trifluoromethyl)phenyl]-;2-bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one;2-Bromo-1-(3-(trifluoromethyl)phenyl)ethanone ,97%
CBNumber
CB7429963
Molecular Formula
C9H6BrF3O
Formula Weight
267.04
MOL File
2003-10-3.mol
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3-(TRIFLUOROMETHYL)PHENACYL BROMIDE Property

Melting point:
22°C
Boiling point:
64-72°C
Density 
1.592±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
liquid
color 
Colourless
CAS DataBase Reference
2003-10-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
1760
Hazard Note 
Corrosive
HazardClass 
8
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

SynQuest Laboratories
Product number
2817-B-05
Product name
3-(Trifluoromethyl)phenacyl bromide
Packaging
250mg
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
100901
Product name
2-Bromo-1-[3-(trifluoromethyl)phenyl]ethanone
Packaging
1g
Price
$71
Updated
2021/12/16
ChemScene
Product number
CS-0018981
Product name
2-Bromo-1-(3-(trifluoromethyl)phenyl)ethanone
Purity
≥97.0%
Packaging
5g
Price
$84
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB106068
Product name
2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone
Packaging
1g
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0018981
Product name
2-Bromo-1-(3-(trifluoromethyl)phenyl)ethanone
Purity
≥97.0%
Packaging
10g
Price
$158
Updated
2021/12/16
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3-(TRIFLUOROMETHYL)PHENACYL BROMIDE Chemical Properties,Usage,Production

Uses

2-Bromo-1-(3-(trifluoromethyl)phenyl)ethyl ketone is a trifluoromethoxylated compound with high membrane permeability, anti-metabolic stability, affinity for lipid membranes, thermal stability, and chemical stability, and is widely used in the pharmaceutical and chemical industries.

Synthesis

349-76-8

2003-10-3

The general procedure for the synthesis of 2-bromo-1-(3-(trifluoromethyl)phenyl)ethanone from 3-(trifluoromethyl)acetophenone was as follows: to a toluene solution (423 mL) of 3-(trifluoromethyl)acetophenone (79.6 g, 0.423 mol) was slowly added pyridinium perbromide (135.4 g, 0.423 mol) under ice-bath cooling conditions. The reaction mixture was stirred for 5 hours, during which time it was allowed to warm up naturally to room temperature. Upon completion of the reaction, the reaction solution was again cooled in an ice bath, followed by slow dropwise addition of distilled water (400 mL) to quench the reaction. Next, the toluene layer was washed with saturated aqueous sodium bicarbonate (400 mL), followed by drying the organic phase with anhydrous magnesium sulfate. The dried organic phase was concentrated under reduced pressure and then purified by reduced pressure distillation to afford the target product 2-bromo-1-(3-(trifluoromethyl)phenyl)ethanone (92.35 g, 81.7% yield). The product was characterized by 1H-NMR (200 MHz, TMS, CDCl3): δ 4.46 (2H, s), 7.66 (1H, brt, J = 7.9 Hz), 7.88 (1H, brd, J = 7.6 Hz), 8.19 (1H, brd, J = 5.5 Hz), 8.25 (1H, brs). The boiling point was 92°C/3 mmHg.

References

[1] Journal of Medicinal Chemistry, 1995, vol. 38, # 1, p. 34 - 41
[2] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4989 - 4990
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1998, vol. 340, # 7, p. 649 - 655
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582
[5] Patent: EP1571148, 2005, A1. Location in patent: Page/Page column 28

3-(TRIFLUOROMETHYL)PHENACYL BROMIDE Preparation Products And Raw materials

Raw materials

3'-(Trifluoromethyl)acetophenone Bromine

Preparation Products

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3-(TRIFLUOROMETHYL)PHENACYL BROMIDE Suppliers

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2003-10-3, 3-(TRIFLUOROMETHYL)PHENACYL BROMIDERelated Search:

2-(TRIFLUOROMETHYL)PHENACYL BROMIDE,2'-(TRIFLUOROMETHYL)PHENACYL BROMIDE 3-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-FLUORO-3-(TRIFLUOROMETHYL)PHENACYL BROMID 3,5-Bis(trifluoromethyl)phenacyl bromide 97%,3,5-BIS(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-(Trifluoromethyl)phenacyl bromide 97%,4-(TRIFLUOROMETHYL)PHENACYL BROMIDE: TECH.,4'-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-FLUORO-3-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-CHLORO-3-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-FLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-CHLORO-5-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-FLUORO-3-(TRIFLUOROMETHYL)PHENACYL BROMIDE 3-FLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2,3-DIFLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-FLUORO-2-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-HYDROXY-2-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-FLUORO-6-(TRIFLUOROMETHYL)PHENACYL BROMIDE 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-FLUORO-5-(TRIFLUOROMETHYL)PHENACYL BROMIDE

  • BUTTPARK 35\01-54
  • 3-(TRIFLUOROMETHYL)PHENACYL BROMIDE
  • 2-BROMO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1-ETHANONE
  • 2-BROMO-1-(3-TRIFLUOROMETHYL-PHENYL)-ETHANONE
  • 2-Bromo-1-[3-(trifluoromethyl)phenyl]-1-ethanone, tech
  • 2-Bromo-3'-(trifluoromethyl)acetophenone
  • 2-Bromo-1-(3-(trifluoromethyl)phenyl)ethanone ,97%
  • 2-Bromo-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one, 3-(Bromoacetyl)benzotrifluoride
  • 2-bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one
  • Ethanone, 2-bromo-1-[3-(trifluoromethyl)phenyl]-
  • 2-Bromo-3'-(trifluoromethyl)acetophenone,98%
  • 3-(Trifluoromethyl)phenacyl bromide (267)
  • 2-Bromo-3′-(trifluoromethyl)acetophenone, CAS 2003-10-3
  • 2003-10-3