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1-METHYLHISTAMINE DIHYDROCHLORIDE

Product Name
1-METHYLHISTAMINE DIHYDROCHLORIDE
CAS No.
6481-48-7
Chemical Name
1-METHYLHISTAMINE DIHYDROCHLORIDE
Synonyms
TIMTEC-BB SBB003561;1-Methylhistamine2HCl;TELE-METHYLHISTAMINE, HCL;1-Methylhistamin-15N2 2HCl;1-Methylhistamin-15N3 2HCl;1-MethylhistaMine ditosylate;1-Methyl histamine dichloride;1-METHYLHISTAMINE DIHYDROCHLORIDE;1-Methylhistamine (hydrochloride);Tele-methylhistamine dihydrochloride
CBNumber
CB7432013
Molecular Formula
C6H13Cl2N3
Formula Weight
198.09
MOL File
6481-48-7.mol
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1-METHYLHISTAMINE DIHYDROCHLORIDE Property

Melting point:
>198°C (dec.)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
color 
Pale Yellow
Water Solubility 
water: 49.00-51.00mg/mL, clear, colorless to faintly yellow
Stability:
Hygroscopic
InChI
InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChIKey
AGXVEALMQHTMSW-UHFFFAOYSA-N
SMILES
NCCC1N=CN(C)C=1.[H]Cl.[H]Cl
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M4910
Product name
1-Methylhistamine dihydrochloride
Purity
≥98% (TLC), powder
Packaging
25mg
Price
$238.45
Updated
2025/07/31
Sigma-Aldrich
Product number
M4910
Product name
1-Methylhistamine dihydrochloride
Purity
≥98% (TLC), powder
Packaging
100mg
Price
$743
Updated
2025/07/31
Cayman Chemical
Product number
19516
Product name
1-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19516
Product name
1-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$254
Updated
2024/03/01
Cayman Chemical
Product number
19516
Product name
1-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$443
Updated
2024/03/01
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1-METHYLHISTAMINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions.

Uses

1-Methylhistamine Dihydrochloride is a selective H1-receptor agonists. Also it has depressant effects.

Biochem/physiol Actions

Major metabolite of histamine by histamine N-methyltransferase.

IC 50

Human Endogenous Metabolite

References

[1] S.-E. LINDELL  R. W S. METABOLISM OF INJECTED [14C]HISTAMINE IN THE KIDNEY OF THE DOG[J]. British Journal of Pharmacology, 1958, 13 1: 52-53. DOI: 10.1111/j.1476-5381.1958.tb00189.x
[2] MOUHAMMAD MOTAWAJ. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease.[J]. Journal of Alzheimer’s disease?: JAD, 2010: 861-871. DOI: 10.3233/jad-2010-100381
[3] YVES DAUVILLIERS. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions.[J]. Sleep, 2012, 35 10: 1359-1366. DOI: 10.5665/sleep.2114

1-METHYLHISTAMINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYLHISTAMINE DIHYDROCHLORIDE Suppliers

China 70 Germany 1 India 2 Switzerland 1 United States 9 Global 83
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

6481-48-7, 1-METHYLHISTAMINE DIHYDROCHLORIDERelated Search:

Histamine Histamine dihydrochloride N'-Methyl-L-histidine methyl ester (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride H-HIS(BZL)-OME 2 HCL 1-METHYLHISTAMINE DIHYDROCHLORIDE 2-AMINO-1-[5-AMINO-1-(PHENYLMETHYL)-1H-IMIDAZOL-4-YL] ETHANONE N-TAU-METHYL-D3-HISTAMINE 2HCL n-Methylhistamine dihydrochloride 2-Methylhistamine dihydrochloride S(+)-α-Methylhistamine dihydrochloride 3-METHYLHISTAMINE DIHYDROCHLORIDE β-Methylhistamine dihydrochloride (S)-2-AMINO-3-(1-METHYL-1H-IMIDAZOL-4-YL)-PROPIONIC ACID 2HCL R(-)-ALPHA-METHYLHISTAMINE DIHYDROCHLORIDE,(R)-(-)-A-methylhistamine*dihydrochloride,(r)(-)-α-methylhistamine dihydrochloride 4-Methylhistamine dihydrochloride N-ALPHA-METHYLHISTAMINE DIHYDROCHLORIDE,NA-METHYLHISTAMINE DIHYDROCHLORIDE,Methylhistamine dihydrochloride Nalpha- METHYLHISTAMINE DIHYDROCHLORIDE, N-ALPHA-[METHYL-3H]-

  • TELE-METHYLHISTAMINE, HCL
  • TIMTEC-BB SBB003561
  • 1-METHYLHISTAMINE DIHYDROCHLORIDE METABO LITE THAT CROSS
  • 1-Methylhistamine2HCl
  • 1-methyl-4-(β-aminoethyl)imidazole dihydrochloride
  • 1-MethylhistaMine ditosylate
  • 2-(1-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride
  • 1-METHYL-4-[BETA-AMINOETHYL]IMIDAZOLE DIHYDROCHLORIDE
  • 1-METHYLHISTAMINE DIHYDROCHLORIDE
  • 1-METHYL-4-[BETA-AMINOETHYL]IMIDAZOLE
  • 1-Methylhistamine (hydrochloride)
  • 2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine dihydrochloride
  • Tele-methylhistamine dihydrochloride
  • Tele-methylhistamine dihydrochloride salt
  • 2-(1-methylimidazol-4-yl)ethanamine dihydrochloride
  • 1-Methylhistamin-15N2 2HCl
  • 1-Methylhistamin-15N3 2HCl
  • 13C,2H3]-Tele-methylhistamine dihydrochloride salt
  • Endogenous Metabolite,1Methylhistamine dihydrochloride,inhibit,Inhibitor,1-Methylhistamine,1 Methylhistamine dihydrochloride
  • 1-Methyl histamine dichloride
  • 1H-Imidazole-4-ethanamine,1-methyl-, hydrochloride (1:2)
  • 1-Methylhistamine dihydrochloride, 10 mM in DMSO
  • 2-(1-methylimidazol-4-yl)ethanamine dihydrochloride - [M87159]
  • 6481-48-7