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ANHYDROTETRACYCLINE HYDROCHLORIDE

Product Name
ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS No.
13803-65-1
Chemical Name
ANHYDROTETRACYCLINE HYDROCHLORIDE
Synonyms
AnhydrotetracyclineHCl;Tetracycline Anhydro HCl;Aureomycin EP impurity J;Anhydrotetracycline HCl, EvoPure;ANHYDROTETRACYCLINE HYDROCHLORIDE;Anhydrotetracycline hydrochloride CRS;5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE;Anhydrotetracycline hydrochloride ,97%;C10258000 AnhydrotetracyclinEHydrochloride;ANHYDROTETRACYCLINE HYDROCHLORIDE USP/EP/BP
CBNumber
CB7438626
Molecular Formula
C22H23ClN2O7
Formula Weight
462.88
MOL File
13803-65-1.mol
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ANHYDROTETRACYCLINE HYDROCHLORIDE Property

Melting point:
223 °C
RTECS 
QI7860000
storage temp. 
Refrigerator
solubility 
Soluble in ethanol, DMSO, or DMF
form 
Powder
color 
Yellow to bright yellow
Sensitive 
Moisture Sensitive
BRN 
4228856
Stability:
Hygroscopic
EPA Substance Registry System
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
63-36
Safety Statements 
36/37/39-26
WGK Germany 
3
HS Code 
29413020
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3175
Product name
Anhydrotetracycline Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
94664
Product name
Anhydrotetracycline hydrochloride
Purity
certified reference material, TraceCERT
Packaging
10mg
Price
$296
Updated
2024/03/01
Sigma-Aldrich
Product number
37919
Product name
Anhydrotetracycline hydrochloride
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1035708
Product name
Anhydrotetracycline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1350
Updated
2024/03/01
Alfa Aesar
Product number
J66688
Product name
Anhydrotetracycline hydrochloride
Packaging
10mg
Price
$66.2
Updated
2024/03/01
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ANHYDROTETRACYCLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.

Chemical Properties

yellow to bright yellow powder

Uses

A Tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems.

Uses

Anhydrotetracycline is a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.

Uses

Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.

ANHYDROTETRACYCLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANHYDROTETRACYCLINE HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
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Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
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75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
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55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55

13803-65-1, ANHYDROTETRACYCLINE HYDROCHLORIDERelated Search:


  • ANHYDROTETRACYCLINE HYDROCHLORIDE
  • AnhydrotetracyclineHCl
  • Anhydrotetracycline hydrochloride, 'can be used as a secondary standard'
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, (4S,4aS,12aS)-
  • 5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE
  • Anhydrotetracycline hydrochloride,'can be used as secondary standard.'
  • Anhydrotetracycline hydrochloride ,97%
  • (4S,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE
  • Lymecycline Impurity 3(Lymecycline EP Impurity C)
  • (4S,4aS,12aS)-4-(DiMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride
  • Anhydrotetracycline hydrochloride CRS
  • Tetracycline Anhydro HCl
  • Aureomycin EP impurity J
  • ANHYDROTETRACYCLINE HYDROCHLORIDE USP/EP/BP
  • Anhydrotetracycline HydrochlorideQ: What is Anhydrotetracycline Hydrochloride Q: What is the CAS Number of Anhydrotetracycline Hydrochloride Q: What is the storage condition of Anhydrotetracycline Hydrochloride Q: What are the applications of Anhydrotetracycline Hydrochloride
  • Anhydrotetracycline Hydrochloride ((4S ,4aS ,12aS )-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-me (1035708)
  • Tetracycline Hydrochloride Impurity C as Hydrochloride
  • (4S,4aS,12aS)-4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide (anhydrotetracycline)
  • Chlortetracycline Hydrochloride Impurity J as Hydrochloride
  • Chlortetracycline Hydrochloride EP Impurity J as Hydrochloride
  • Tetracycline Hydrochloride EP Impurity C as Hydrochloride
  • 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,hydrochloride (1:1), (4S,4aS,12aS)-
  • Anhydrotetracycline HCl, EvoPure
  • Anhydrotetracycline hydrochloride in methanol
  • C10258000 AnhydrotetracyclinEHydrochloride
  • 13803-65-1
  • Drug Analogues
  • Intermediates & Fine Chemicals
  • Pharmaceuticals