2-Benzyloxyphenylboronic acid

Product Name: 2-Benzyloxyphenylboronic acid
CAS No.: 190661-29-1
Chemical Name: 2-Benzyloxyphenylboronic acid
Synonyms: AKOS BRN-0079;CAS:190661-29-1;RARECHEM AH PB 0042;2-Benzyloxyphenylboronic;O-BENZYLOXYPHENYLBORONIC ACID;2-BENZYLOXYPHENYLBORONIC ACID;2-BENZYLOXYBENZENEBORONIC ACID;2-BENZYLOXYPHENYLBORORNIC ACID;(2-phenylmethoxyphenyl)boronicaci;2-Phenylmethoxy Phenylboronic Acid
CBNumber: CB7452822
Molecular Formula: C13H13BO3
Formula Weight: 228.05
MOL File: 190661-29-1.mol

More

Less

2-Benzyloxyphenylboronic acid Property

Melting point:: 105-110 °C(lit.)
Boiling point:: 428.7±47.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane, Ethyl Acetate, Methanol
form: Solid
pka: 8.57±0.53(Predicted)
color: White
BRN: 7813704
CAS DataBase Reference: 190661-29-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: C,Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-36
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: IRRITANT, CORROSIVE
HS Code: 29319090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 521337
Product name: 2-(Benzyloxy)phenylboronic acid
Packaging: 1g
Price: $54.6
Updated: 2022/05/15

TCI Chemical

Product number: B4590
Product name: 2-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B4590
Product name: 2-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $131
Updated: 2025/07/31

TRC

Product number: B287740
Product name: 2-(Benzyloxy)phenylboronic acid
Packaging: 2.5g
Price: $1260
Updated: 2021/12/16

Oakwood

Product number: 016104
Product name: 2-(Benzyloxy)phenylboronic acid
Purity: 97%
Packaging: 1g
Price: $10
Updated: 2021/12/16

More

Less

2-Benzyloxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Palladium complex-catalyzed selective hydroxylation ? Palladium(II)-catalyzed oxidative Heck reactions ? Metal-free electrophilic fluorination ? Suzuki-Miyaura cross-coupling reactions

Uses

2-Benzyloxyphenylboronic acid is a reagent used in the preparation of different kinase inhibitors.

Uses

Reactant for:• ;Palladium complex-catalyzed selective hydroxylation1• ;Palladium(II)-catalyzed oxidative Heck reactions2• ;Metal-free electrophilic fluorination3• ;Suzuki-Miyaura cross-coupling reactions4

Uses

suzuki reaction

Synthesis

31575-75-4

190661-29-1

General procedure for the synthesis of 2-benzyloxyphenylboronic acid from 2-benzyloxybromobenzene: 1) 19.93 mL of BuLi (1.6 M hexane solution, 31.9 mM, 1 eq.) was slowly added to a 50 mL THF solution containing 8.4 g of 2-benzyloxybenzene bromide (31.9 mM, 1 eq.) via syringe at -78 °C. Stirring was continued at -78 °C for 30 min to obtain a THF solution of the lithiated derivative. 2) Through a dropping funnel, the above lithiated derivative solution was slowly added dropwise at -78°C to a 50 mL THF solution containing 30 g of B(OiPr)3 (159.5 mM, 5 eq.). 3) After the dropwise addition was completed, the reaction mixture was allowed to gradually warm up to room temperature and stirring was continued for 4 hours. 4) The reaction mixture was poured into 20 mL of 3N HCl to quench the reaction, extracted twice with 50 mL of EtOAc, the organic phases were combined, washed with water, dried over anhydrous MgSO4, and concentrated to dryness under reduced pressure to give 8.53 g of crude product. (5) The crude product was purified by silica gel column chromatography with 9:1 cyclohexane/EtOAc as eluent, and finally 3.6 g of pure product was obtained in 47% yield.

References

[1] Organic Letters, 2004, vol. 6, # 24, p. 4595 - 4597
[2] Patent: US2005/154048, 2005, A1. Location in patent: Page/Page column 17

2-Benzyloxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Trimethyl borate Benzyl chloride N,N-Dimethylformamide Potassium carbonate Tetrahydrofuran 2-Bromophenol n-Butyllithium

Preparation Products

More

Less

2-Benzyloxyphenylboronic acid Suppliers

Americas 1 Canada 2 China 136 Europe 4 France 2 Germany 11 India 9 Italy 1 Japan 6 Russia 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 55 Global 248

Discovery Fine Chemicals Ltd.

Tel: --
Fax: --
Email: info@discofinechem.com
Country: United Kingdom
ProdList: 530
Advantage: 58

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Fisher Scientific Uk Ltd.

Tel: --
Fax: --
Email: .international@thermofisher.com
Country: United Kingdom
ProdList: 2932
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Archimica UK

Tel: --
Fax: --
Country: United Kingdom
ProdList: 190
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Key Organics Ltd.

Tel: --
Fax: --
Email: enquiries@keyorganics.net
Country: United Kingdom
ProdList: 851
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Molekula Ltd

Tel: --
Fax: --
Email: info@molekula.com
Country: United Kingdom
ProdList: 4060
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

Hawks Scientific Ltd

Tel: --
Fax: --
Email: pete@hawks-scientific.com
Country: United Kingdom
ProdList: 2221
Advantage: 43

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

Zerenex Molecular Limited

Tel: --
Fax: --
Email: sales@zerenex-molecular.com
Country: United Kingdom
ProdList: 6204
Advantage: 47

More

Less

View Lastest Price from 2-Benzyloxyphenylboronic acid manufacturers

Career Henan Chemical Co

Product: 2-Benzyloxyphenylboronic acid 190661-29-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-03

190661-29-1, 2-Benzyloxyphenylboronic acidRelated Search:

4-Methoxybenzyl alcohol 4-Tolylboronic acid Anisole 2-Phenoxyethanol 4-Methoxyphenylacetic acid Phenylboronic acid p-Anisaldehyde (Trifluoromethoxy)benzene 4-Methoxybenzylchloride o-Anisaldehyde (4-METHOXYPHENYL)-BORANE m-Anisyl alcohol 4-Methoxyphenylboronic acid 4-Methoxybenzoic acid Citric acid Ascoric Acid 3-BROMO-2-(3'-FLUOROBENZYLOXY)-5-METHYL& 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID

AKOS BRN-0079

2-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride)

2-BENZYLOXYBENZENEBORONIC ACID

2-BENZYLOXYPHENYLBORONIC ACID

RARECHEM AH PB 0042

O-BENZYLOXYPHENYLBORONIC ACID

2-Phenylmethoxy Phenylboronic Acid

2-BENZYLOXYPHENYLBORORNIC ACID

2-Benzyloxyphenylboronic

2-(Phenylmethoxy)benzeneboronic acid

2-(Phenylmethyl)oxyphenylboronic acid

2-Benzyloxyphenylboronic acid ,98%

B-[2-(PhenylMethoxy)phenyl]boronic Acid

2-Benzyloxybenzeneboronic acid(contains varying aMounts of Anhydride)

2-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride) &gt

Boronic acid, B-[2-(phenylmethoxy)phenyl]-

(2-phenylmethoxyphenyl)boronicaci

CAS:190661-29-1

2-Benzyloxyphenylboronic acid - [B1600]

190661-29-1

C6H5CH2OC6H4BOH2

C13H13BO3

C13H13O3B

Boronic Acids and Derivatives

Organometallic Reagents

Aryl

Boronic Acids

Boronic Acids and Derivatives

Chemical Synthesis

Monosubstituted Aryl Boronic Acids

Organometallic Reagents

Boronate Ester

Potassium Trifluoroborate

Boronic acids

Boronic acid

Organoborons

Aryl

Boronic Acids

Boronic Acids and Derivatives

Aryl Boronic Acids

blocks

BoronicAcids