ChemicalBook > CAS DataBase List > ABX-1431

ABX-1431

Product Name
ABX-1431
CAS No.
1446817-84-0
Chemical Name
ABX-1431
Synonyms
CS-2856;ABX-1431;Elcubragistat;ABX1431;ABX 1431;ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor;1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CBNumber
CB74667484
Molecular Formula
C20H22F9N3O2
Formula Weight
507.39
MOL File
1446817-84-0.mol
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ABX-1431 Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26023
Product name
ABX-1431
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
26023
Product name
ABX-1431
Packaging
50mg
Price
$1184
Updated
2024/03/01
Cayman Chemical
Product number
26023
Product name
ABX-1431
Packaging
5mg
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
26023
Product name
ABX-1431
Packaging
10mg
Price
$333
Updated
2024/03/01
AK Scientific
Product number
0863DV
Product name
CID71657619
Packaging
10mg
Price
$245
Updated
2021/12/16
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ABX-1431 Chemical Properties,Usage,Production

Description

ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.

References

1) Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062

ABX-1431 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABX-1431 Suppliers

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1446817-84-0, ABX-1431Related Search:

Tigecycline 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) AZ20 SGI 7079 Gilteritinib N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine UNC2541

  • CS-2856
  • ABX1431;ABX 1431
  • ABX-1431
  • 1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
  • 1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate
  • 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate
  • ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor
  • Elcubragistat
  • 1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate
  • 1446817-84-0
  • C20H22F9N3O2