ABX-1431

Product Name: ABX-1431
CAS No.: 1446817-84-0
Chemical Name: ABX-1431
Synonyms: CS-2856;ABX-1431;Elcubragistat;ABX1431;ABX 1431;ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor;1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CBNumber: CB74667484
Molecular Formula: C20H22F9N3O2
Formula Weight: 507.39
MOL File: 1446817-84-0.mol

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ABX-1431 Property

storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 50mg
Price: $1184
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 5mg
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 26023
Product name: ABX-1431
Packaging: 10mg
Price: $333
Updated: 2024/03/01

AK Scientific

Product number: 0863DV
Product name: CID71657619
Packaging: 10mg
Price: $245
Updated: 2021/12/16

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ABX-1431 Chemical Properties,Usage,Production

Description

ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.

References

1) Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062

ABX-1431 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABX-1431 Suppliers

China 46 India 1 United States 7 Global 54

A.J Chemicals

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1446817-84-0, ABX-1431Related Search:

Tigecycline 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) AZ20 SGI 7079 Gilteritinib N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine UNC2541

CS-2856

ABX1431;ABX 1431

ABX-1431

1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate

1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate

ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor

Elcubragistat

1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate

1446817-84-0

C20H22F9N3O2