Pirimiphos-methyl Property

Melting point:

15°C

Boiling point:

386.5±52.0 °C(Predicted)

Density 

d30 1.157

vapor pressure 

1.5×10^-2 Pa (30°C)

refractive index 

nD25 1.527

Flash point:

-18 °C

storage temp. 

APPROX 4°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

pka

3.71

Water Solubility 

9.9 mg l^-1 (30 °C, pH 5.2)

form 

Liquid

color 

Light yellow to yellow

Merck 

13,7580

BRN 

755726

LogP

4.2 at 20℃

CAS DataBase Reference

29232-93-7(CAS DataBase Reference)

NIST Chemistry Reference

Pirimiphos methyl(29232-93-7)

EPA Substance Registry System

Pirimiphos-methyl (29232-93-7)

Safety

Hazard Codes 

Xn,N,F

Risk Statements 

22-50/53-67-65-38-11

Safety Statements 

60-61-62

RIDADR 

UN3082 9/PG 3

WGK Germany 

3

RTECS 

TF1410000

Hazardous Substances Data

29232-93-7(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Pirimiphos-methyl Chemical Properties,Usage,Production

Chemical Properties

Light yellow, straw colored, or amber oily liquid. Odorless when pure.

Uses

Pirimiphos-methyl is used to control a wide range of insect and mite pests in stored products and a wide range of insects and mites on agricultural crops, particularly sucking pests under glass.

Uses

Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects.

Definition

ChEBI: An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.

General Description

Yellow liquid. Corrosive to tin and mild steel. Used as an insecticide.

Air & Water Reactions

Hydrolyzed by strong acid or base.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Flammability and Explosibility

Not classified

Agricultural Uses

Insecticide, Acaricide: Pirimiphos-methyl is a post-harvest insecticide used to control a variety of insects in stored grain products and seed such as corn, rice, wheat and sorghum. It is also incorporated into cattle ear tags, and used for the fogging treatment of iris bulbs and pre-harvest clean up of fruits and vegetables.

Trade name

ACTELLIC®; ACTELLIFOG®; BLEX®; ENT 27699Gc®; DOMINATOR® EAR TAG; DOUBLE BARREL® EAR TAG; PLANT PROTECTION PP511®; PP511®; SILOSAN®; SYBOL®; TOMAHAWK®[C]

Safety Profile

Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.

Potential Exposure

Pirimiphos-methyl is a post -harves organophosphate insecticide/acaricide used to control a variety of insects in stored grain products and seed such as corn, rice, wheat and sorghum. It is also incorporated into cattle ear tags, and used for the fogging treatment of iris bulbs and preharvest cleanup of fruits and vegetables.

Carcinogenicity

When rats were given diets with 0, 10, 50, or 300 ppm pirimiphos methyl (equivalent to 0, 0.4, 2.1, or 12.6 mg/kg/day) for 2 years, 4 of the 42 high-dose male rats had pancreatic islet cell adenomas and 1 had a carcinoma compared to none in control male rats . In a carcinogenicity study, mice were given diets with 0, 50, 200, or 400/300 ppm pirimiphos methyl (equivalent to 0, 8.3, 33, or 52 mg/kg/day (males); 0, 9.7, 39, or 61 mg/kg/day (females)) for 78 weeks . The initial 400 ppm dose resulted in excessive toxicity and moribundity and was reduced to 300 ppm after 8 days. There was no evidence of carcinogenicity. In another mouse carcinogenicity study, pirimiphos methyl was administered in the diet at levels of 0, 5, 250, or 500 ppm (equivalent to 0, 0.5, 25.9, or 45.0 mg/kg/ day (males) and 0, 0.6, 27.6, or 50.6 mg/kg/day (females), respectively) for 80 weeks. The test diet for the highest dose groups initially contained 300 ppm of the test compound (the duration of treatment was not specified). The dose was then increased weekly by 50 ppm to 500 ppm. No evidence of carcinogenicity was observed.

Metabolic pathway

The metabolism of pirimiphos-methyl is similar in soils, plants and animals and can be represented by initial hydrolysis to yield 2-diethylamino- 6-methyl-p yrimidin-4-0l which may be either conjugated or successively N-de-ethylated. In plants, pirimiphos-methyl itself is N-de-ethylated. It is probable that the oxon form of the compound is formed in many systems but it is more labile than the parent compound and is often not detected. 0-Dealkylation, as with most organophosphates, is most probably a major detoxification route in mammals but the evidence for it in the case of pirimiphos-methyl is poor.

Shipping

UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Degradation

Pirimiphos-methyl is hydrolysed under both acidic and basic conditions and is most stable at pH 7 (PM). The main product of hydrolysis was the pyrimidinol (2). There is no information, however, on the degradation products formed under either acidic or basic conditions. The DT₅₀ of degradation was in the range of 3-4 days in sterile deionised water in the dark. Photolysis was rapid but the products of photolytic breakdown were not described (PSD, 1997).

Incompatibilities

May react violently with antimony(V) pentafluoride. Incompatible with strong acids and alkalies, lead diacetate, magnesium, silver nitrate. In the presence of strong reducing agents such as hydrides, organophosphates form highly toxic and flammable phosphine gas. Contact with oxidizers can cause the release of toxic oxides of phosphorus.

Waste Disposal

Destruction by alkali hydrolysis or incineration. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.