ChemicalBook > CAS DataBase List > UC2288

UC2288

Product Name: UC2288
CAS No.: 1394011-91-6
Chemical Name: UC2288
Synonyms: UC2288;UC2288 ，E1190;UC 2288, trans;p21 Inhibitor, UC2288;UC2288, 10 mM in DMSO;UC2288, p21 inhibitor;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-;rac-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1R,4R)-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea , UC2288
CBNumber: CB74718667
Molecular Formula: C20H18ClF6N3O2
Formula Weight: 481.82
MOL File: 1394011-91-6.mol

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UC2288 Property

Boiling point:: 491.9±45.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml
form: A solid
pka: 12.88±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.32813
Product name: p21 Inhibitor, UC2288
Packaging: 10 mg
Price: $263
Updated: 2025/07/31

Ambeed

Product number: A1462621
Product name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity: 98%
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Ambeed

Product number: A1462621
Product name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity: 98%
Packaging: 250mg
Price: $97
Updated: 2021/12/16

Ambeed

Product number: A1462621
Product name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
Purity: 98%
Packaging: 1g
Price: $241
Updated: 2021/12/16

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UC2288 Chemical Properties,Usage,Production

Uses

UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM[1].

Biological Activity

Cell permeable: yes

in vivo

UC2888 (oral gavage; 15 mg/kg; 3 times a week; 4 weeks) co-treatment with imetelstat significantly suppresses tumor growth and does not effect mice weight^[2].UC2288 (intraperitoneal injection; 10 mg/kg; 4 times in 7 days) attenuates MPTP-induced behavioral impairment, prevents activation of MAPK pathway in the MPTP-treated mice brain. MPTP treatment raises TNF-α, IL-6 and IL-1β levels in MPTP treated mice brain, but UC2288 signicantly decreases MPTP-induced TNF-α, IL-6 levels, but IL-1β is not decreased in brain^[3].

Animal Model:	Eight-week old, athymic nude (NCr nu/nu) mice injected subcutaneously with HCT116 and ACHN cancer cells(2.5x10⁶)^[2]
Dosage:	15 mg/kg
Administration:	Oral gavage; 3 times a week; 4 weeks; co-treatment with imetelstat
Result:	Combined treatment with imetelstat synergistically inhibited tumor growth in mice.

Animal Model:	MPTP-induced C57BL6 Parkinson’s disease mice model^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal?injection; 4 times in 7 days
Result:	Ameliorated MPTP induced PD progression through inhibition of neuroinammation.

References

[1] Hiromi I Wettersten, et al. A Novel p21 Attenuator Which Is Structurally Related to Sorafenib. Cancer Biol Ther.?2013 Mar;14(3):278-85. DOI:10.4161/cbt.23374
[2] Romi Gupta, et al. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3062-71. DOI:10.1073/pnas.1411370111
[3] Jun Hyung Im, et al. p21 inhibitor UC2288 ameliorates MPTP induced Parkinson’s disease progression through inhibition of oxidative stress and neuroinammation. Translational Medicine.Neurobiology of Disease

UC2288 Preparation Products And Raw materials

Raw materials

Preparation Products

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UC2288 Suppliers

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1394011-91-6, UC2288Related Search:

UCT943 5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol 2-PHENYLMELATONIN

UC2288

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea

Attenuator,786-O,Inhibitor,UC-2288,MDM-2/p53,inhibit,UC2288,ovarian,RCC,HK2,UC 2288,p21,sorafenib,p53-mutant,cancer

Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-

UC 2288, trans

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea , UC2288

UC2288, p21 inhibitor

UC2288, 10 mM in DMSO

p21 Inhibitor, UC2288

rac-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1R,4R)-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea

UC2288 ，E1190

1394011-91-6